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120

This is the amount of days a typical RBC lives for in the bloodstream

14-16

This is the amount of RBCs produced from a single pluripotent stem cell

American Society for Clinical Pathologists

This group organizes RBC maturation in these stages: Rubriblast, prorubricyte, rubricyte, metarubricyte, reticulocyte, erythrocyte (RPRMRE)

Basophilic normoblast (Prorubricyte)

During this stage of maturation, the n/c ratio is 4:1, the cytoplasm is a darker blue, the nucleus exhibits HALO around the nucleus, and there is some chromatin clumping. The cell is about 12-17um

Bone marrow

This is where blood cells are produced including all of the RBCs and 60-70% of WBCs (granulocytes)

College of American Pathologists

This group organizes RBC maturation in these stages: Pronormoblst, basophilic normoblast, polychromatophilic normoblast, orthchromic normolast, reticulocyte, erythrocyte (PBPORE)

Erythroblasts

These ar red blood cell precursers found in bone marrow

Erythrocyte

During this stage of maturation the nucleus is gone, the cell moves into the blood, and the cell is a salmon color and is 6-8um in size.

Erythrocyte

This is name for red blood cells

Erythropoiesis

This term means the production of red blood cells

Erythropoietin (EPO)

This is a hormone produced in the kidneys that controls RBC production.

Hematopoeisis

This is the production, differentiation, and maturation of red blood cells.

Lymphoid stem cells

This type of stem cell can become B and T lymphocytes.

Maturation

During this process, the cytoplasm fades in color (blue to pink), cell size decreases, and the nucleus becomes smaller

Myeloid stem cell

This type of stem cell can become erythrocytes, thrombocytes, monocytes, and granulocytes.

Normoblast

This is another name for red blood cell precursors

Orthochromic normoblast (Metarubricyte)

During this stage of maturation, the n/c ratio is 1:1, the cytoplasm is a pink/orange color due to hemoglobin, the nucleus is small and puknotic, and the cell size is 8-12um

Pluripotent stem cells

This type of cell can become myeloid and lymphoid stem cells

Polychromatic normoblast (Rubricyte)

During this stage of maturation, the n/c ratio is 4:1, the cytoplasm is a grey-blue, the nucleus has a condensed and clumped chromatin witha wagon wheel appearance in the nucleus, and the cell size is 12-15um.

Pronormoblast (Rubriblast)

During this stage of maturation, the n/c ratio is 4:1, the cytoplasm is dark blue, the nucleus is a deep violet with some chromatin clumping, and the cell is about 14-19um

Red Marrow

This type of bone marrow is responsible for blood production being in almost all bones as a child and then being only in flat bones in adulthood (Flat bones)

Reticulocyte

During this stage of maturation the n/c is no longer existant, the cell is pink, it is shaped as biconcave, the nucleus is gone, and the cell size is 7-10um.

Yellow marrow

This is the result of bone marrow turning into fat cells which are not involved in blood production

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