5 Written Questions

1. Hives. Intensely pruritic wheals that form after mast cell degranulation . Dilated superficial lymphatic channels
2. Pruritic eruption, commonly on skin flexures. Often associated with ASTHMA and allergic rhinitis
3. Irregular areas of complete depigmentation. Caused by a decrease in melanocytes
4. Common mole. Benign
5. Normal melanocyte number with decreased melanin production due to decreased activity of tyrosinase. Can also be caused by failure of neural crest cell migration during development

5 Matching Questions

1. Ephelis
2. Actinic chelitis
3. Pemphigus vulgaris
4. Pityriasis rosea
5. Dermatitis herpetiformis

1. a can result in SCC due to sunexposure; ulcerated lesion that may appear on the vermillion of the lip
2. b Herald path followed days later by Christmas tree distribution. Multiple papular eruptions; remits spontaneously
3. c Freckle. Normal number of melanocytes but increase melanin pigment
4. d Potentially fatal autoimmune skin disorder with IgG antibody against desmosomes (anti-epithelial cell antibody); immunofluoresecence reveals antibodies around cells of epidermis in a reticular or netlike pattern.
5. e Pruritic papules and vesicles. Deposits of IgA at the tips of dermal papillae. Associated with celiac disease

5 Multiple Choice Questions

1. Hyperpigmentation associated with pregnancy ("mask of pregnancy") or OCP use
   1. Ephelis
   2. Melasma
   3. Psoriasis
   4. verrucae
2. Very superficial skin infection. Usually from S. Aureus or S. Pyogenes. Highly contagious and honey colored crusting
   1. Ephelis
   2. Vitiligo
   3. Impetigo
   4. Melasma
3. Hyperplasia of the stratum spinosum. Associated with hyperinsulinemia and visceral malignancy
   1. Acantholysis
   2. Actinic chelitis
   3. Acanthosis nigricans
   4. Actinic keratosis
4. Papules and plaques with SILVERY SCALING especially on knees and elbows. Acanthosis with parakeratotic scaling (nuclei still in stratum corneum). Increased stratum spinosum and decreased granulosum. Auspitz sing (bleeding spots when scales are scraped off. Can be associted with nail pitting and psoriatic arthritis
   1. Ephelis
   2. Urticaria
   3. Albinism
   4. Psoriasis
5. Acute, painful spreading of infection of dermis and subcutaneous tissues. Usually from S. pyogenes or S. Aureus
   1. Ephelis
   2. Cellulitis
   3. Albinism
   4. Vitiligo

5 True/False Questions

1. Erythema nodosum → Inflammatory lesions of subcutaneous fat, usually on anterior shins. Associated with coccidioidomycosis, histoplasmosis, TB, leprosy, streptococcal infections, sarcoidosis

   True        False

2. Acantholysis → intraepidermal bullae involving the skin and oral mucosa

   True        False

3. Staphylococcal scalded skin syndrome (SSSS) → Exotoxin destroys keratinocyte attachments in the stratum granulosum only. Chracterized by fever and generalized erythematous rash with sloughing of the upper layers of the epidermis. Seen in newborns and children

   True        False

4. verrucae → Hyperpigmentation associated with pregnancy ("mask of pregnancy") or OCP use

   True        False

5. Actinic keratosis → can result in SCC due to sunexposure; ulcerated lesion that may appear on the vermillion of the lip

   True        False