5 Written questions
5 Matching questions
- Two major factors of plasmodium pathogenesis
- Does plasmodium have antigenic variation?
- List the different species of mosquitoes that can harbor malaria and what region
- 2 main factors for resistance to Plasmodium
- a Africa - Anopheles gambiae / Asia - Anopheles stephensi / South America - Anopheles darlingi
- b 1. Anemia arising from RBC destruction (merozoites released) 2. Host inflammatory response (overproduction of cytokines, fevers and chills)
- c Found in plasmodium apicomplexans. A pigment they produce as a result of hemoglobin breakdown.
- d Yep
- e 1. Duffy Blood group in west africans protects against p. vivax 2. Sickle cell trait - the heterozygous individuals. Selected for in African ancestries.
5 Multiple choice questions
- heteroxenous - mosquito and hman.
- P. falciparum
- Easier to control vector in temperature regions and in developed countries there is more money and more advanced infrastructure.
- 1. Plasmodium falciparum 2. Plasmodium vivax 3. Plasmodium malariae 4. Plasmodium ovale 5. Plasmodium knowlesi
5 True/False questions
Treatment of malaria - problems? → Chloroquine, Quinine, Mefloquine, Artemisinin. Drug resistance has developed for these drugs - Chloroquine sucks and Artemisinin is the best, but drug resistance to everything is a problem.
John went backpacking in Asia and South America 8 years ago, and now he has malaria? How? → P. vivax
Why are some people in Africa resistant to Malaria? → P. vivax, invades young RBC's using a single receptor. The DUFFY BLOOD GROUPS or DUFFY ANTIGENs, makes them resistant . Fy=resistant. Fy^a or Fy^b = susceptible.
Benign Tertian Malaria → 48 hr recurring fevers, More drawn out. P. falciparum
Main way to eliminate malaria → Killing vector or preventing vector contact - insecticides, larvicides, bed nets