5 Written questions
5 Matching questions
- List the different species of mosquitoes that can harbor malaria and what region
- Benign Tertian Malaria
- Sickle cell trait
- Factors that affect plasmodium transmission
- Main way to eliminate malaria
- a Africa - Anopheles gambiae / Asia - Anopheles stephensi / South America - Anopheles darlingi
- b Killing vector or preventing vector contact - insecticides, larvicides, bed nets
- c 1. Human reservoirs that are aymptomatic 2. Naïve host 3. Vector 4. Climate
- d P. vivax. BTM is when you have 48 hr recurring fevers.
- e single a.a. substitution. Homozygosity usually results in death by age 30. Heterozygosity confers 80-95% protection against severe malaria. Selected for only in Africa.
5 Multiple choice questions
- 1. Clinical manifestations of disease 2. Visualization of parasites in stained blood smears 3. Dipstick method for detecting antigen 4. PCR
- There will always be asymptomatic carriers
- P. malariae
- P. falciparum
- Mosquito bite (sporozoite injection) or blood transfusion
5 True/False questions
*Clinical symptoms of plasmodium infection → 1. Severe anemia 2. Cerebral malaria (coma, seizures, deadly in 25-50%) because RBC's become sticky in brain. Cytokines and NO production 3. Placental malaria (infection of the placenta, not transplacental, reduces blood flow to baby - low birth weight and still birth. 4. Can also lead to hypoglycemia and hepatosplenomegally, and pulmonary edema and kidney failure.
How does hemozoin screw things up? Drugs do what? → syngamy followed by sporogony
Etiological agent of Malaria → P. vivax. BTM is when you have 48 hr recurring fevers.
Plasmodium is vectored by → 1. Clinical manifestations of disease 2. Visualization of parasites in stained blood smears 3. Dipstick method for detecting antigen 4. PCR
Why is Plasmodium not as prevalent in temperate regions and developed countries? → 1. Pigment called Hemozoin 2. Apical complex lacks conoid 3. Zygotes are motile, known as ookinetes 4. Sporozoites are not enclosed in sporocysts.