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5 Written Questions

5 Matching Questions

  1. Life cycle of plasmodium in mosquito
  2. Definitive host of plasmodium is
  3. Why are some people in Africa resistant to Malaria?
  4. 2 main factors for resistance to Plasmodium
  5. Sickle cell trait
  1. a 1. Duffy Blood group in west africans protects against p. vivax 2. Sickle cell trait - the heterozygous individuals. Selected for in African ancestries.
  2. b single a.a. substitution. Homozygosity usually results in death by age 30. Heterozygosity confers 80-95% protection against severe malaria. Selected for only in Africa.
  3. c P. vivax, invades young RBC's using a single receptor. The DUFFY BLOOD GROUPS or DUFFY ANTIGENs, makes them resistant . Fy=resistant. Fy^a or Fy^b = susceptible.
  4. d After the ring stage trophozoites comes out of liver and produces all the gametocytes, the mosquito bites and ingests the gametocytes from the blood. 1. Macrogamete and microgamete form zygote 2. Ookinete develops and crosses midgut epithelium 3 Ookinete to oocyst 4. Oocyst gives rise to sporozoites via sporogony and the sporozoites go to salivary gland to be injected into host.
  5. e mosquito

5 Multiple Choice Questions

  1. One merozoite could produce billions of parasites in 2 weeks. Humans can develop tolerance, premunition and keeping parasite at low levels. Infants protected by maternal antibodies.
  2. P. malariae
  3. P. vivax
  4. 48 hr recurring fevers, More drawn out. P. falciparum
  5. malaria - plasmodium

5 True/False Questions

  1. Two major factors of plasmodium pathogenesis1. Severe anemia 2. Cerebral malaria (coma, seizures, deadly in 25-50%) because RBC's become sticky in brain. Cytokines and NO production 3. Placental malaria (infection of the placenta, not transplacental, reduces blood flow to baby - low birth weight and still birth. 4. Can also lead to hypoglycemia and hepatosplenomegally, and pulmonary edema and kidney failure.

          

  2. Invades any RBC72 hr recurring fevers

          

  3. *Clinical symptoms of plasmodium infection1. Severe anemia 2. Cerebral malaria (coma, seizures, deadly in 25-50%) because RBC's become sticky in brain. Cytokines and NO production 3. Placental malaria (infection of the placenta, not transplacental, reduces blood flow to baby - low birth weight and still birth. 4. Can also lead to hypoglycemia and hepatosplenomegally, and pulmonary edema and kidney failure.

          

  4. Etiological agent of Malariaplasmodium

          

  5. Most common in tropical regions of the developing worldPlasmodium

          

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