5 Written Questions
4 Matching Questions
- How do you get malaria?
- Life cycle of plasmodium in vertebrate
- Ancient disease.
- 50% of malaria cases
- a P. falciparum
- b 1. Mosquito injects SPOROZOITE into blood 2. sporozoite invades liver cells and becomes TROPHOZOITE 3. Replication by exoerythrocytic schizogony, trophozoites to MEROZOITES 4. merozoites released and attack RBCs 5. merozoites to RING STAGE TROPHOZOITES (cycles back to merozoites or macrogametocyte) 6. Macrogametocytes and microgametocytes form zygote.
- c Plasmodium - P. Falciparum believed to have killed Egyptian pharaohs 1500 B.C
- d Mosquito bite (sporozoite injection) or blood transfusion
5 Multiple Choice Questions
- 4 widely known, 1 new recent one.
- There will always be asymptomatic carriers
- Fevers are tied to generation of merozoites and rupture of RBC's. Rupture causes fever. Less synchrony in P. falciparum, so you have more constant fever
- asexual schizogony
- P. vivax
5 True/False Questions
Why do Duffy antigens not help against P. falciparum? → Killing vector or preventing vector contact - insecticides, larvicides, bed nets
Plasmodium is vectored by → 1. Clinical manifestations of disease 2. Visualization of parasites in stained blood smears 3. Dipstick method for detecting antigen 4. PCR
Why is Plasmodium not as prevalent in temperate regions and developed countries? → Easier to control vector in temperature regions and in developed countries there is more money and more advanced infrastructure.
Factors that affect plasmodium transmission → 1. Human reservoirs that are aymptomatic 2. Naïve host 3. Vector 4. Climate
Invades any RBC → 72 hr recurring fevers