5 Written Questions
5 Matching Questions
- How is Plasmodium different from other apicomplexans?
- What does P. falciparum do when it infects RBCs
- Can a baby catch malaria from mom?
- Life cycle of plasmodium in vertebrate
- How do you get malaria?
- a No, but sticky RBCs cause low birth weight and thus stillbirth
- b The infected RBCs bind to epithelium causes knobs and rosettes, and ruins clearance in liver and spleen
- c 1. Pigment called Hemozoin 2. Apical complex lacks conoid 3. Zygotes are motile, known as ookinetes 4. Sporozoites are not enclosed in sporocysts.
- d 1. Mosquito injects SPOROZOITE into blood 2. sporozoite invades liver cells and becomes TROPHOZOITE 3. Replication by exoerythrocytic schizogony, trophozoites to MEROZOITES 4. merozoites released and attack RBCs 5. merozoites to RING STAGE TROPHOZOITES (cycles back to merozoites or macrogametocyte) 6. Macrogametocytes and microgametocytes form zygote.
- e Mosquito bite (sporozoite injection) or blood transfusion
5 Multiple Choice Questions
- P. vivax can relapse after up to 8 years, fight it or treat it. Hypnozoite stage in liver is dormant stage.
- P. malariae
- After the ring stage trophozoites comes out of liver and produces all the gametocytes, the mosquito bites and ingests the gametocytes from the blood. 1. Macrogamete and microgamete form zygote 2. Ookinete develops and crosses midgut epithelium 3 Ookinete to oocyst 4. Oocyst gives rise to sporozoites via sporogony and the sporozoites go to salivary gland to be injected into host.
- P. vivax
5 True/False Questions
Treatment of malaria - problems? → Chloroquine, Quinine, Mefloquine, Artemisinin. Drug resistance has developed for these drugs - Chloroquine sucks and Artemisinin is the best, but drug resistance to everything is a problem.
How does plasmodium replicate in mosquito? → asexual schizogony
Two major factors of plasmodium pathogenesis → 1. Anemia arising from RBC destruction (merozoites released) 2. Host inflammatory response (overproduction of cytokines, fevers and chills)
You catch this disease more easily during wartime because of breaks in sanitation → 4 widely known, 1 new recent one.
Most common in tropical regions of the developing world → P. falciparum