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SGU Histo Urinary

kidney development

glomerulus invaginates renal tubule -> bowman's capsule

bowman space

receives filtrate

urinary pole

bowman's space cont w/ PCT, form filtrate through hydrostatic P

JGA

assoc w/ each renal corpuscle, vascular pole, 3 parts: 1) macula densa, 2) extraglomular mesangial cells, 3) JG cells, gap junctions betw the types

macula densa

distal tubule betw arterioles, inc cell #, reg renin secr by sensing dec NaCl

extraglomular mesangial / Lacis cells

betw macula densa + JG, may have granules, may be support cells affect by Angiotensin II

JG cells

mod smooth mm of afferent (and some efferent) glomerulus arterioles, sense Bp changes -> endocrine secretory cells for renin -> liver secretes angiotensin, large PAS-staining vesicles

renin

makes liver secrete angiotensin

Angiotensin II

formed from Angiotensin I via ACE = angiotensin converting enzyme/angiotensinase, in endoth lung alveoli, stim Aldosterone synth in zona glomerulosa, vasoconstricter

Angiotensin III

formed by choroid plexus capps, stim Aldosterone synth, but weakly vasoconstrict like a poor-man's Angiotensin II

intraglomular mesangial cells

CT of glomerulus, analg to pericytes, cov area not cov by podocytes, actin microfils, Angiotensin I receptors, some are phagocytes, secr GFs + mediators of inflamm renal disease

podocyte

epith cells of visc layer of renal corpuscle, long procs w/ sec pedicle procs that are the only part that touch the GBM

pedicles

interdigitating foot procs of podocytes (sec procs) that contain lots of actin fils, space betw = filtration slits, makes the GBM

GBM

glomerular basement memb, thick and stained w/ PAS, bl-urine barrier that is fusion of two basal laminae: podocyte + endothelial cell laminae, has 3 parts: 1)podocyte lamina rara, 2) fused lamina densa, 3) endoth lamina rara

PCT

simple cuboidal epith, very eosinophilic, brush border, very large cells, 80% of filtrate resorbed is returned to circ (Glc, AAs, prots, vits), secretes H+, HCO3-, organic HA/Bs, penicillins, etc, have smooth SER w/ CytP450 for detox => lipofuscin bodies show up w/age

Loop of Henle

thick desc seg -> thin desc seg w/ simple squamous epith -> thin asc -> thick asc w/ simple cuboidal epith -> transition to DCT at macula densa

DCT

in cortical labyrinth, 1/3 as long as PCT, forms macula densa, less eosinophilic than PCT, no obvious brush border like PCT, smaller diam than PCT, more nuclei than PCT, func as Na+ sensor, stim by Aldosterone, resorb HCO3-/secr H+ (pH bal), conv ammonia to ammonium ion, target tissue for diuretecs + natriuretic factors to inhib Na+ reabsorb => dec Bp

Aldosterone

stim Na+ reabs + K+ secretion in DCT

medullary ray

middle part of cortical/renal lobule, group of straight tubes that lead to collecting ducts

collecting duct

consist of light + dark cells, light = most comm, imperm to ions, ADH sens aquaporins (=> allow H2O absorb w/ osmotic grad, allows urea to exit), dark = dec in number toward medulla, secrete H+ into urine

interstitial cells

kidney parenchyma CT, w/ fibroblast-like + macrophage-like cells

vasa recta

counter current exchange sys, fenest capps, passive mov of ions + H2O, Desc: H2O moves out + solutes move in, Tip: 1M [urea], Asc: H2O moves in, salt moves out => osmotic grad drives flow of H2O and no E is used

ureter

stellate shape, no musc mucosa, musc externa (inner + outer longtid + middle circ, note the reverse order)

bladder

has 3 muscular layers, very transitional epith w/ apical plaques

Urodilatin

Kidney natriurietc peptide, dec Bp (remove Na+ + H2O vs ADH/vasopressin, and R-AgT sys, works w/ atrial + brain natriuretic factors

erythropoetin / EPO

stim BM erythrocyte synth, in renal cortex interstitium, imp for athlete doping, kidney failure, or sclerotic defects

Pro VitD / Calcitriol

steroid essent for Ca2+ bal

transitional epithelium

urinary epith: imperm to salts + H2O, ability to become thinner + flatten, irreg apical surface w/ deep clefts

male urethra

prostatic (trans epith), membranous (strat squam epith), penile (strat squam epith) (bulbourethral /Cowper's glands, intraepith Glands of Littre), longer

female urethra

many urethral + paraurethral glands -> duct -> Skene's Gland (equiv to prostate), shorter, mucosa w/ longtid folds

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