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5 Written Questions

5 Matching Questions

  1. flucytosine
  2. phenytoin
  3. terbutaline, orcipenaline
  4. clopidogrel
  5. cromoglycate, nedcromil
  1. a Antiepileptic. Use-dependent Na+ blockade. 2nd line for PARTIAL and generalised TONIC-CLONIC seizures. SEs: cyp450 inducer, gum hyperplasia/ acne/ hirsuitism, fetal - affects palate and heart
  2. b Antiplatelet. Blocks ADP receptor on platelets, therefore inhibits ADP-induced platelet aggregation. May cause severe bleeding.
  3. c mast cell stabilisers (preventers for asthma)
  4. d short acting beta agonists (relievers for asthma).
  5. e antimetabolite antifungal, targets nucleic acid synthesis

5 Multiple Choice Questions

  1. Antihypertensive. Renin inhibitor (approved 2007), possibly useful in diabetic nephropathy. SEs: hypotension, hyperkalaemia.
  2. polyene antifungal (disrupts cell membrane integrity by binding to ergosterol) only used topically e.g. candida albicans
  3. Antiplatelet. Monoclonal antibody that antagonises GIIb/a receptor on platelets, prevents binding of fibrinogen to platelets. Hospital use only.
  4. Antiplatelet. COX inhibitor. Indications: arterial thrombosis (e.g. stroke and MI prevention, post- surgery). Not useful for venous thrombosis.
  5. Antihypertensive. Diuretic. Carbonic anhydrase inhibitor (acts at PCT) which inhibits H+ secretion and Na+ reabsorption.

5 True/False Questions

  1. griseofulvinBroad spectrum antihelmintic. Cl- channel opener at NMJ (GABA agonist) - inhibits helminth muscle.

          

  2. amiodaroneclass III antiarrhythmic. prolongs refractory period and slows AV conduction. serious side effects (thyroid, lungs, liver)

          

  3. class II antiarrhythmicsB blockers used post-MI and for AF e.g. propranolol, atenolol, metoprolol

          

  4. beta blockersGABA agonist used for Huntington's disease.

          

  5. phentolamineNon-selective alpha 1+2 adrenoreceptor blocker in smooth muscle. Vasodilation. Used in phaeochromocytoma (HT due to adrenal tumor) and erectile dysfunction. SEs: first dose syncope, postural hypotension, reflex tachycardia, urinary urgency,

          

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