5 Written Questions
5 Matching Questions
- tinidazole, metronidazole
- a Antiprotozoal e.g. amoebiasis, giardiasis, trichomoniasis. Also used for some bacterial anaerobes. Nitroimidazoles, interfere with DNA synthesis. e.g. trichomonas vaginalis
- b muscarinic antagonist used in early stage PD. SEs: dry mouth, constipation, urinary retention.
- c MAO-B inhibitor, used in PD. Minor side effects (insomnia and headaches). Reduces wearing off associated with levodopa.
- d class III antiarrhythmic. prolongs refractory period and slows AV conduction. serious side effects (thyroid, lungs, liver)
- e an imidazole antifungal (targets ergosterol synthesis via 14-aemethylase) - only used topically (vaginal/ skin)
5 Multiple Choice Questions
- Antiplatelet. Phosphodiesterase inhibitor (inhibits platelet aggregation).
- Broad spectrum antihelmintic. Nicotinic agonist (inhibits cholinesterase), causes spastic paralysis of helminths. Poorly absorbed from GIT, few SEs.
- G-CSF. Stimulates production and function of neutrophils. Used after cancer chemotherapy, bone marrow transplant and in AML.
- Megakaryocyte growth factor, used in thrombocytopenia after cancer chemotherapy.
- calcium channel blockers used in AF (block slow calcium entry responsible for conduction in nodal tissues) e.g. verapamil and diltiazem
5 True/False Questions
amphotericin → polyene antifungal (disrupts cell membrane integrity by binding to ergosterol) used for asperigillus and candida (orally, IV, topically)
nifedipine, amlodipine → Iron chelator. For acute iron toxicity or haemachromatosis, forms a complex with ferric iron and is excreted in urine. Orally absorbed, careful monitoring required (risk of agranulocytosis)
epoietin alpha/ beta → class of drugs for angina, reduce oxygen demand by reducing heart rate e.g. atenolol, metoprolol, propanolol
heparin → Anticoagulant, enhances action of antithrombin III (binds to clotting factors). Use acutely for DVT, PE, surgery, unstable angina.
spironolactone, eplerenome → aldoterone antagonist potassium-sparing diuretics (act on late DCT and collecting tubules). Used for CHF, and with thiazide or loop diuretics to produce diuresis without hypokalaemia.