5 Written Questions
5 Matching Questions
- cromoglycate, nedcromil
- isosorbide dinitrate
- tinidazole, metronidazole
- a mast cell stabilisers (preventers for asthma)
- b Vasopressin analogue. Normalises haemostasis in vWD for several hours, used for minor procedures such as dental extraction.
- c Antiprotozoal e.g. amoebiasis, giardiasis, trichomoniasis. Also used for some bacterial anaerobes. Nitroimidazoles, interfere with DNA synthesis. e.g. trichomonas vaginalis
- d longer term nitrate for angina, given subligually and orally
- e a triazole antifungal (targets ergosterol synthesis via 14-aemethylase) - used topically and orally. Penetrates well into brain - used for cryptococcal meningitis
5 Multiple Choice Questions
- COMT inhibitors, used alone or with levodopa and DDCIs (prolongs half life of levodopa). Used in PD.
- Broad spectrum antihelmintic. Nicotinic agonist (inhibits cholinesterase), causes spastic paralysis of helminths. Poorly absorbed from GIT, few SEs.
- Recombinant human EPO. Used in CRF, primary bone marrow disorder, and anaemias secondary to chemotherapy.
- Iron chelator. For acute iron toxicity or haemachromatosis, forms a complex with ferric iron and is excreted in urine. Orally absorbed, careful monitoring required (risk of agranulocytosis)
- DA antagonist used for Huntington's disease.
5 True/False Questions
bretylium → class III antiarrhythmic. adrenergic neurone blocker, prolongs AP.
amphotericin → PD drug (mild relief in early stage PD), action unclear.
ketoconazole → an imidazole antifungal (targets ergosterol synthesis via 14-aemethylase) - used topically and orally. Causes liver toxicity and inhibits steroidogenesis.
spironolactone, eplerenome → mast cell stabilisers (preventers for asthma)
fluticasone, budesonide → corticosteroids (preventers for asthma)