5 Written questions
5 Matching questions
- hydrochlorothiazide, indapamide
- fluticasone, budesonide
- a thiazide diuretics (act on distal tubule, increase Na+ and K+ excretion, decrease Ca+ excretion. initially reduced CO, longer term normal CO, decreased TPR). Used for hypertension, diabetes insipidus, and oedema due to CHF, renal or hepatic disease.
- b Antiplatelet. COX inhibitor. Indications: arterial thrombosis (e.g. stroke and MI prevention, post- surgery). Not useful for venous thrombosis.
- c Antiepileptic. Use-dependent Na+ blockade. 1st line for partial and generalised TONIC-CLONIC seizures. SEs: cyp450 inducer, bone marrow depression
ALSO used as mood stabiliser in acute manic phase of bipolar disorder (particuarly with patients that rapidly cycle through manic depressive phases)
- d Antiplatelet. Phosphodiesterase inhibitor (inhibits platelet aggregation).
- e corticosteroids (preventers for asthma)
5 Multiple choice questions
- loop diuretics (act on thick ascending limb to block Na+/K+2Cl- transporter). Used for salt/ water overload associated with acute pulmonary oedema, CHF, liver cirrhosis and renal failure.
- GABA agonist used for Huntington's disease.
- COMT inhibitors, used alone or with levodopa and DDCIs (prolongs half life of levodopa). Used in PD.
- Antiprotozoal e.g. amoebiasis, giardiasis, trichomoniasis. Also used for some bacterial anaerobes. Nitroimidazoles, interfere with DNA synthesis. e.g. trichomonas vaginalis
- non- cardioselective calcium channel blockers for angina and hypertension (induce vasodilation, decrease afterload and preload), INCREASE HR (reflex)
5 True/False questions
clonidine, methyl dopa → Centrally acting alpha2 adrenoreceptor agonists (sympathetic inhib). Vasodilatory. Rarely used for hypertension. SEs: sedation, depression, rebound HT on withdrawal
atenolol, metoprolol → B1 selective antagonist for angina, hypertension and arrhythmia (class II)
beta blockers → class of drugs for angina, reduce oxygen demand by reducing heart rate e.g. atenolol, metoprolol, propanolol
chlorpomazine → DA antagonist used for Huntington's disease.
fluconazole → a triazole antifungal (targets ergosterol synthesis via 14-aemethylase) - used topically and orally. Penetrates well into brain - used for cryptococcal meningitis