5 Written questions
5 Matching questions
- class IV antiarrhythmics
- a calcium channel blockers used in AF (block slow calcium entry responsible for conduction in nodal tissues) e.g. verapamil and diltiazem
- b Obtained from blood donations. Contains concentrated vWF, given in severe vWD.
- c an imidazole antifungal (targets ergosterol synthesis via 14-aemethylase) - used topically and orally. Causes liver toxicity and inhibits steroidogenesis.
- d Antiepileptic. Specifically blocks T-type Ca channels within thalamus. 1st line for ABSENCE seizures.
- e class III antiarrhythmic. adrenergic neurone blocker, prolongs AP.
5 Multiple choice questions
- DA antagonist used for Huntington's disease.
- Depletes DA within brain, used for Huntington's disease.
- Iron chelator. For acute iron toxicity or haemachromatosis, forms a complex with ferric iron and is excreted in urine. IM, IV or intragastric.
- Antiprotozoal e.g. amoebiasis, giardiasis, trichomoniasis. Also used for some bacterial anaerobes. Nitroimidazoles, interfere with DNA synthesis. e.g. trichomonas vaginalis
- Antiepileptic. Use-dependent Na+ blockade. 1st line for partial and generalised TONIC-CLONIC seizures. SEs: cyp450 inducer, bone marrow depression
ALSO used as mood stabiliser in acute manic phase of bipolar disorder (particuarly with patients that rapidly cycle through manic depressive phases)
5 True/False questions
amiodarone → Benzimidazole - antihelmintic for intestinal nematodes e.g. threadworm, hookworm, whipworm, roundworm. Impairs microtubule synthesis.
Absorbed from GIT, drug of choice for mixed intestinal worm infection, also active against some protozoa and cestodes e.g. tissue tapeworms.
aliskiren → Antiplatelet. COX inhibitor. Indications: arterial thrombosis (e.g. stroke and MI prevention, post- surgery). Not useful for venous thrombosis.
clotrimazole → an imidazole antifungal (targets ergosterol synthesis via 14-aemethylase) - only used topically (vaginal/ skin)
class II antiarrhythmics → calcium channel blockers used in AF (block slow calcium entry responsible for conduction in nodal tissues) e.g. verapamil and diltiazem
heparin → Anticoagulant, enhances action of antithrombin III (binds to clotting factors). Use acutely for DVT, PE, surgery, unstable angina.