5 Written Questions
5 Matching Questions
- terbutaline, orcipenaline
- cromoglycate, nedcromil
- a Antiepileptic. Use-dependent Na+ blockade. 2nd line for PARTIAL and generalised TONIC-CLONIC seizures. SEs: cyp450 inducer, gum hyperplasia/ acne/ hirsuitism, fetal - affects palate and heart
- b Antiplatelet. Blocks ADP receptor on platelets, therefore inhibits ADP-induced platelet aggregation. May cause severe bleeding.
- c mast cell stabilisers (preventers for asthma)
- d short acting beta agonists (relievers for asthma).
- e antimetabolite antifungal, targets nucleic acid synthesis
5 Multiple Choice Questions
- Antihypertensive. Renin inhibitor (approved 2007), possibly useful in diabetic nephropathy. SEs: hypotension, hyperkalaemia.
- polyene antifungal (disrupts cell membrane integrity by binding to ergosterol) only used topically e.g. candida albicans
- Antiplatelet. Monoclonal antibody that antagonises GIIb/a receptor on platelets, prevents binding of fibrinogen to platelets. Hospital use only.
- Antiplatelet. COX inhibitor. Indications: arterial thrombosis (e.g. stroke and MI prevention, post- surgery). Not useful for venous thrombosis.
- Antihypertensive. Diuretic. Carbonic anhydrase inhibitor (acts at PCT) which inhibits H+ secretion and Na+ reabsorption.
5 True/False Questions
griseofulvin → Broad spectrum antihelmintic. Cl- channel opener at NMJ (GABA agonist) - inhibits helminth muscle.
amiodarone → class III antiarrhythmic. prolongs refractory period and slows AV conduction. serious side effects (thyroid, lungs, liver)
class II antiarrhythmics → B blockers used post-MI and for AF e.g. propranolol, atenolol, metoprolol
beta blockers → GABA agonist used for Huntington's disease.
phentolamine → Non-selective alpha 1+2 adrenoreceptor blocker in smooth muscle. Vasodilation. Used in phaeochromocytoma (HT due to adrenal tumor) and erectile dysfunction. SEs: first dose syncope, postural hypotension, reflex tachycardia, urinary urgency,