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5 Written Questions

5 Matching Questions

  1. salbutamol
  2. mebendazole
  3. abciximab
  4. ferrous sulphate
  5. clotrimazole
  1. a an imidazole antifungal (targets ergosterol synthesis via 14-aemethylase) - only used topically (vaginal/ skin)
  2. b Oral iron therapy for iron deficiency anaemia. Continued for 2 - 3 months. SEs: nausea, abdominal cramps, constipation/ diarrhoea
  3. c short acting beta agonist (reliever for asthma). also called ventolin.
    Also, relaxation of uterine smooth muscle (e.g. delays preterm labour - but mainly nifedipine, a calcium channel blocker, is used). SE: skeletal muscle tremor.
  4. d Benzimidazole - antihelmintic for intestinal nematodes e.g. threadworm, hookworm, whipworm, roundworm. Impairs microtubule synthesis.
    Pooly absorbed from GIT, few SEs.
  5. e Antiplatelet. Monoclonal antibody that antagonises GIIb/a receptor on platelets, prevents binding of fibrinogen to platelets. Hospital use only.

5 Multiple Choice Questions

  1. class III antiarrhythmic.non-selective B blocker with class III activity (prolongs AP and refractory period)
  2. loop diuretics (act on thick ascending limb to block Na+/K+2Cl- transporter). Used for salt/ water overload associated with acute pulmonary oedema, CHF, liver cirrhosis and renal failure.
  3. Antihypertensive (esp. in emergency) vasodilator (mainly arteriolar). Interferes with IP3 on Ca release from SR.
  4. GM-CSF. Used to treat neutropenia in chemotherapy and after bone marrow transplant.
  5. infrequently used antimuscarinic broncodilator for asthma. produces bronchodilation by blocking vagal tone.

5 True/False Questions

  1. desferrioxamineIron chelator. For acute iron toxicity or haemachromatosis, forms a complex with ferric iron and is excreted in urine. IM, IV or intragastric.


  2. tolcapone, entacaponeCOMT inhibitors, used alone or with levodopa and DDCIs (prolongs half life of levodopa). Used in PD.


  3. benzotropinemuscarinic antagonist used in early stage PD. SEs: dry mouth, constipation, urinary retention.


  4. deferiproneMAO-B inhibitor, used in PD. Minor side effects (insomnia and headaches). Reduces wearing off associated with levodopa.


  5. bretyliuminfrequently used antimuscarinic broncodilator for asthma. produces bronchodilation by blocking vagal tone.


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