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5 Written questions

5 Matching questions

  1. nystatin
  2. capsofungin
  3. amorolfine
  4. phentolamine
  5. ketoconazole
  1. a antifungal that targets cell wall synthesis - IV use only for invasive aspergillosis
  2. b Non-selective alpha 1+2 adrenoreceptor blocker in smooth muscle. Vasodilation. Used in phaeochromocytoma (HT due to adrenal tumor) and erectile dysfunction. SEs: first dose syncope, postural hypotension, reflex tachycardia, urinary urgency,
  3. c antifungal that disrupts cell membrane synthesis. used in laquer for nails to treat onychomycoses
  4. d an imidazole antifungal (targets ergosterol synthesis via 14-aemethylase) - used topically and orally. Causes liver toxicity and inhibits steroidogenesis.
  5. e polyene antifungal (disrupts cell membrane integrity by binding to ergosterol) only used topically e.g. candida albicans

5 Multiple choice questions

  1. DDCIs, used in combination with levodopa in PD.
  2. class of drugs for angina that increase venous, arteriolar and coronary dilation e.g. isosorbide dinitrate and nitroglycerin (not to be used with viagra)
  3. aldoterone antagonist potassium-sparing diuretics (act on late DCT and collecting tubules). Used for CHF, and with thiazide or loop diuretics to produce diuresis without hypokalaemia.
  4. parenteral iron therapy (IM or IV). Indications: unable to absorbe oral iron in iron deficiency. SEs: fever, arthralgia, nausea, abdominal cramps, vomiting
  5. antimetabolite antifungal, targets nucleic acid synthesis

5 True/False questions

  1. praziquantelAntihelmintic- treatment of intestinal tapeworms (cestodes). Causes tetanic-like contractions in worm muscle by altering calcium permeability, worms detached from host tissue.

          

  2. azolesclass of antifungals that disrupt cell membrane integrity. Bind to ergosterol e.g. amphotericin and nystatin.

          

  3. ferrous sulphateObtained from blood donations. Contains concentrated vWF, given in severe vWD.

          

  4. tolcapone, entacaponeCOMT inhibitors, used alone or with levodopa and DDCIs (prolongs half life of levodopa). Used in PD.

          

  5. beta blockersclass of drugs for angina, reduce oxygen demand by reducing heart rate e.g. atenolol, metoprolol, propanolol

          

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