5 Written questions
5 Matching questions
- carbidopa, benserazide
- nifedipine, amlodipine
- a class of antifungal cell membrane synthesis inhibitors. Target ergosterol synthesis via 14-aemethylase
- b non- cardioselective calcium channel blockers for angina and hypertension (induce vasodilation, decrease afterload and preload), INCREASE HR (reflex)
- c DDCIs, used in combination with levodopa in PD.
- d Iron chelator. For acute iron toxicity or haemachromatosis, forms a complex with ferric iron and is excreted in urine. Orally absorbed, careful monitoring required (risk of agranulocytosis)
- e infrequently used broncodilator for asthma. contains methylxantine that relaxes smooth muscle.
5 Multiple choice questions
- Antihypertensive. Osmotic diuretic, acts on whole nephron. Blocks tubular water resorption and reduces Na+ resorption rate.
- Broad spectrum antihelmintic. Nicotinic agonist (inhibits cholinesterase), causes spastic paralysis of helminths. Poorly absorbed from GIT, few SEs.
- non- selective B1 and B2 antagonist used for angina, arrhythmia (class II) and hypertension
- antimetabolite antifungal, targets nucleic acid synthesis
- MAO-B inhibitor, used in PD. Minor side effects (insomnia and headaches). Reduces wearing off associated with levodopa.
5 True/False questions
spironolactone, eplerenome → COMT inhibitors, used alone or with levodopa and DDCIs (prolongs half life of levodopa). Used in PD.
beta blockers → GABA agonist used for Huntington's disease.
sargramostim → GM-CSF. Used to treat neutropenia in chemotherapy and after bone marrow transplant.
tranexamic acid → Antihypertensive. Diuretic. Carbonic anhydrase inhibitor (acts at PCT) which inhibits H+ secretion and Na+ reabsorption.
aspirin → Antiplatelet. COX inhibitor. Indications: arterial thrombosis (e.g. stroke and MI prevention, post- surgery). Not useful for venous thrombosis.