Veterinary Science:Parasitology-Pharmacology-Modes of Action

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What target these drugs share, Nicotine, levamisole, pyrantel, oxantel, imidacloprid, nitenpyram, spinosad?

Synapse

What MOA do these drugs share, Nicotine, levamisole, pyrantel, oxantel, imidacloprid, nitenpyram, spinosad?

Activate acetylcholine receptors

What parasite group(s) are Nicotine, levamisole, pyrantel, oxantel, imidacloprid, nitenpyram, spinosad, effective against?

helminths, arthropods

What is the traget of Organochlorines, phenyl pyrazoles?

Synapse

What is the Mode of Action of Organochlorines, phenyl pyrazoles?

Block GABA-gated Cl- channels

What are Organochlorines, phenyl pyrazoles effective against?

arthropods

What is the target of Piperazine?

Synapse

What is the Mode of Action of Piperazine?

Activate GABA-gated Cl- channels

What parasite group is Piperazine effective against?

nematodes

What target are Macrocyclic lactones aimed at?

Synapse

What is the Mode of Action of Macrocyclic lactones?

Activate glutamate-gated Cl- receptors

What parasite group(s) are Macrocyclic Lactones effective against?

helminths and arthropods

What is the target of Organophosphates, carbamates?

Synapse

What is the Mode of Action of Organophosphates, carbamates?

ACh'estase inhibitor

What parasitic groups are Organophosphates, carbamates effective against?

arthropods, nematodes

What is the target of Emodepside?

Synapse

What is the Mode of Action of Emodepside?

Activate latrophilin receptor

What is Emodepside effective against?

nematodes

What is the target of Amitraz?

CNS

What is the mode of action of Amitraz?

activate octopamine receptors

What parasite group is Amitraz effective against?

acarines

What is the target of pyrethroids, organochlorines, metaflumizone?

nerve fibres

What is the Mode of Action of Pyrethroids, organochlorines, metaflumizone?

prolong Na+ chennel opening

What parasitic group are Pyrethroids, organochlorines, metaflumizone effective against?

arthroppods

What is the target of Rotenone, dinitrophenol, atovaquone, decoquinate, dichlorophene, salicylanilides, nitrophenol?

cellular respiration

What is the Mode of Action of Rotenone, dinitrophenol, atovaquone, decoquinate, dichlorophene, salicylanilides, nitrophenol?

inhibit e-transport, uncouple ATP production

What parasite groups are Rotenone, dinitrophenol, atovaquone, decoquinate, dichlorophene, salicylanilides, nitrophenol effective agasints?

arthropods, helminths, protozoa

What is the target of Benzimidazoles?

Microtubules

What is the Mode of Action of Benzimidazoles?

inhibit syntheses of microtubles by binding to B-tubulin

What parasite groups are Benzimidazoles effective against?

helminths, protoza

What is the target of Benzylphenylureas?

Chittin synthesis

What it the Mode of Action of Benzylphenylureas?

Inibition of chittin synthesis

What parasite groups is Benzylphenylureas effective against?

arthropods

What is the target of Cyromazine, methoprene, pyriproxyfen, dicyclanil?

Moulting

What is the Mode of Action for Cyromazine, methoprene, pyriproxyfen, dicyclanil?

Juvenile hormone agonoists, Triazines

What parasitic groups are Cyromazine, methoprene, pyriproxyfen, dicyclanil effective against?

arthropods

What is the target of Action of Praziquantel, epsiprantel?

cell function

What is the Mode of Action of Praziquantel, epsiprantel?

Activate voltage-gated Ca+ channels

What are Praziquantel, epsiprantel effective against?

Platyhelminths

What is the target of Clorsulon?

Glycolysis

What is the Mode of Action of Clorsulon?

Inhibition of glycolysis

What parasite groups is Clorsulon effective against?

trematodes

What is the target of Piperonyl butoxide?

Mixed Function Oxidases

What is the Mode of Action for Piperonyl butoxide?

Inhibition of MFO

What parasitic group(s) are Piperonyl butoxide effective against?

arthropods

What is the target of Sodium ionophores?

Cell function

What is the Mode of Action of Sodium ionophores?

Promote intracellular uptake of Na+ and H+

What parastic groups are Sodium ionophores effective against?

Protozoa, coccidia

What is the target of Melarsomine?

Protein denaturing

What is the Mode of Action of Melarsomine?

Binds to cystine

What parasitic group is Melarsomine effective against?

filaria

What is the target of Sulphonamides, trimethoprim, pyrimethamine?

Folic acid

What is the mode of action of Sulphonamides, trimethoprim, pyrimethamine?

Inhibit synthesis, metabolism of Folic Acid

What parasitic groups are Sulphonamides, trimethoprim, pyrimethamine effective against?

protozoa

What is the target of Amprolium?

Thiamine

What is the mode of action of Amprolium

Inhibit utilisation

What parasitic groups is Amprolium effective against?

protozoa

What is the target of Aromatic diamidines (imidocarb), quinacrine?

DNA

What is the Mode of Action of Aromatic diamidines (imidocarb), quinacrine?

DNA, RNA binding

What parasitic groups are Aromatic diamidines (imidocarb), quinacrine effective against?

protoza

What is the target of Metronidazole, dimetridazole?

DNA

What is the Mode of Action of Metronidazole, dimetridazole?

DNA synthesis

What parasitic groups are Metronidazole, dimetridazole effective against?

protozoa

What is the target of Clindamycin?

Protein synthesis

What it the Mode of Action of Clindamycin?

Binds to ribosomes

What parasitic groups are Clindamycin effective against?

protozoa

What is the target of B. Thuringensis toxin?

Gut

What is the Mode of Action of B. Thuringensis toxin?

Direct damage to cells in the Gut

What parasitic groups is B. Thuringensis toxin effective against?

Arthropods, helminths

What is the target of Diclazuril, tolrazuril, ponazuril?

Nuclear division

What is the Mode of Action of Diclazuril, tolrazuril, ponazuril?

inhibit nuclear division

What parasitic groups are Diclazuril, tolrazuril, ponazuril effective against?

protozoa

What is the target of Nicarbazin

Unknown

What is the Mode of Action of Nicarbazin?

unknown

What parasite groups are Nicarbazin effective against?

protozoa

Who is acknowledged for this content of these questions?

Prof Jim Rothwell, School of Veterinary Science, University of Queensland (Gatton), Australia

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