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IgM

attached to B cells/free in plasma; serves as an antigen receptor when bound to a B cell; 1st Ig released to plasma by plasma cells; agglutination agent; fixes complement

IgA

monomer found in plasma, dimer found in secretions (mucous, tears, saliva, HCL, milk); protects mucosal surfaces from pathogens

IgD

attached to B cell; activates B cells

IgG

most abundant antibody in plasma; main antibody of primary/secondary responses; crosses placenta; fixes complement

IgE

secreted by plasma cells in skin and mucosae; allergic response

IgM

pentamer

IgD, IgG, IgE

Y shaped monomers

IgA

monomer or dimer

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