5 Written questions
5 Matching questions
- ADME scheme
- facilitated diffusion
- passive diffusion
- C min
- administration of drugs
- a administration routes of drugs play large role in drug absorption, 2 major mehtods: a) enteral means thru gastroint tract. b)parenteral: entrance outside of GI tract, usually via injection.
- b absorption, distribution, metabolism and elimination.
- c no atp. carrier protein assists drug in entering cell
- d physiochemical makeup helps determine how easy or difficult drug passes thru membranes (concentration gradient, how lipophilic and surface area of cell)
- e minimum trough concentration
5 Multiple choice questions
- can easily get out of blood stream
- maximum concentration:
- looks at how drugs act in the body and deals with [At the site of action, what the drug does] mechanisms of action in addition to the actions of different drug concentrations or doses
- determine how readily crosses membrane. uncharged chemicals more easily pass membranes. weak acids and bases can be charged or uncharged, but each drug's charge changes based on interaction with body's pH
- time for drug concentration to fall by half
5 True/False questions
parenteral administration (a. IV, b. subcutaneous, c. intramuscular, d. intraarterial, e. intrathecal) → a)enteric coated allows drug to pass thru stomach without being destroyed by gastric acid. b)controlled release preparation allows drug to release a uniform stream to absorption site over relatively long period of time (disadvantages of this include differences between patients, failure of controlled release causing dose dumping or reduced drug release)other forms of enteral administration
Good whole food vitamin → inhalation, intranasal, topical, transdermal (nicotine patches)
pharmacokinetics → describes action of drugs wihtin body and absorption, [How drugs move in body and how quickly] distrib, metabolism and elimination of drugs in addition to the rate or kinetics at which drug's actions begin and their duration. "ADD ME" (sp?) scheme
protein binding → most drugs reversibly bind to plasma proteins. drugs bound to albumin is going to be inactive. albumin is the most common protein in the plasma, albumin keeps blood within the blood vessels. As plasma concentration of the drug increases, more binding occurs.
absorption → rate and extent that the drugs leaves site of administration. a)how long it takes for an oral drug to enter bloodstream from small intestine and how much of the drug makes it. b. bioavailability: [how much of a drug makes it into the bloodstream] what fraction of the dose of a drug reaches its site of actino or a body fluid where the drug has accss to its action.