5 Written questions
5 Matching questions
- charge of drug
- Enteral administration. a. enteric coated pills, b.controlled release pills
- t 1/2
- protein binding
- a looks at how drugs act in the body and deals with [At the site of action, what the drug does] mechanisms of action in addition to the actions of different drug concentrations or doses
- b time for drug concentration to fall by half
- c determine how readily crosses membrane. uncharged chemicals more easily pass membranes. weak acids and bases can be charged or uncharged, but each drug's charge changes based on interaction with body's pH
- d a)enteric coated allows drug to pass thru stomach without being destroyed by gastric acid. b)controlled release preparation allows drug to release a uniform stream to absorption site over relatively long period of time (disadvantages of this include differences between patients, failure of controlled release causing dose dumping or reduced drug release)other forms of enteral administration
- e most drugs reversibly bind to plasma proteins. drugs bound to albumin is going to be inactive. albumin is the most common protein in the plasma, albumin keeps blood within the blood vessels. As plasma concentration of the drug increases, more binding occurs.
5 Multiple choice questions
- can easily get out of blood stream
- atp required. carrier protein assists drug in entering cell
- a. intravenous: aqueous solution injected into a vein, b. subcutaneous: inject below skin in subc tissues, c. intramuscular into muscles, d. intraarterial: rare b/c makes bleed a ton, e. intrathecal: inject into cerebrospinal fluid of spinal subarachnoid space. OVERALL: parenteral have many advantages over oral admin including more rapid extensive and predictable admin, can be given to unconscious patients. disadvantages include necessity for aseptic protocols/pain/difficult self-med.
- minimum trough concentration
- physiochemical makeup helps determine how easy or difficult drug passes thru membranes (concentration gradient, how lipophilic and surface area of cell)
5 True/False questions
Factors that affect bioavailability → a. first pass hepatic metabolism: first pass metabolism refers to drugs entering hepatic portal system from intestines, b. drug solubility: very hydrophilic or hydrophobic drugs have difficulty crossing cell membranes and entering most drugs prefer to be hydrophobic and a little hydrophilic so they can pass cell membranes easily., c. chemical instability: some drugs may be affected by stomach's pH or various degradative enzymes in GI tract., d. chemicophysical properties of the drug(suzem salt form)
Good whole food vitamin → New process
absorption → the prcoess thru which the drug leaves the bloods tream and enters interstitium (absorption is about intestines, distrib is about bloodstream). 4 aspects: blood flow, capillary permeability, drug structure, degree of binding to proteins
administration of drugs → determine how readily crosses membrane. uncharged chemicals more easily pass membranes. weak acids and bases can be charged or uncharged, but each drug's charge changes based on interaction with body's pH
degree of blood flow in brain/liver/kidneys, skeletal muscles and skin, adipose tissues → brain, liver, kidneys have excellent blood flow, skeletal muscles and skin less, adipose tissues even less.