5 Written Questions

1. Ergot alkaloid and partial DA agonist
2. Non-ergot (preferred)
3. Increases DA release, toxicity = ataxia
4. Antimuscarinic - improves tremor and rigidity but has little effect on bradykinesia
5. COMT inhibitor acts peripherally - prevents L-dopa degradation thereby increasing DA availability

5 Multiple Choice Questions

1. Non-ergot (preferred)
   1. Tolcapone
   2. Ropinirole
   3. Amantidine
   4. Carbidopa
2. Used as antiviral agent against influenza A and rubella
   1. Carbidopa
   2. Amantidine
   3. Selegiline
   4. Benztropine
3. COMT inhibitor acts centrally - prevents L-dopa degradation thereby increasing DA availability
   1. Tolcapone
   2. Ropinirole
   3. Selegiline
   4. Entacapone
4. Ergot alkaloid and partial DA agonist
   1. Selegiline
   2. Benztropine
   3. Carbidopa
   4. Pergolide
5. Selective MAO type B inhibitor (preferentially metabolizes DA over NE and 5-HT). Prevents DA breakdown.
   1. Selegiline
   2. Benztropine
   3. Amantidine
   4. Pergolide

5 True/False Questions

1. Bromocriptine → Used first line for prolactinomas

   True        False

2. Carbidopa → Converted to DA in CNS

   True        False

3. Trihexhyphenidyl → Non-ergot (preferred)

   True        False

4. Benztropine → Antimucarinic - used for drug-induced parkinsonism e.g. following typical antipsychotic Rx

   True        False

5. L-dopa → COMT inhibitor acts centrally - prevents L-dopa degradation thereby increasing DA availability

   True        False