5 Written Questions
5 Matching Questions
- Describe distribution's role in drug-herb interactions and how protein binding affects drug-herb interactions
- What are some drugs that are highly protein bound and thus more susceptible to drug-herb interactions?
- Describe metabolism's role in drug herb interactions
- Neurotransmitter for Sympathetic nervous system.
- what is eaton-lambert syndrome?
- a A drug or herb with the majority ofits active ingredients being highly protein bound are very susceptible to interactions
- b Warfarin, phenytoin, oral contraceptive pills, and non-steroidal anti-inflammatory drugs (NSAIDS)
- c noradrenaline, why it is known as "Adrenergic nervous system"
- d One of the biggest targets of interactions within this realm is the cytochrome P450 system, which can be inhibited or promoted by some substances
- e a rare autoimmune disorder which inhibits voltage gated calcium channels on the presynaptic membrane of the neuromuscular junction, preventing acetalcholine from being released, so muscles do not contract. cholinergic agonists help to treat this syndrome.
5 Multiple Choice Questions
- inhibit parasympathetic functions. antispasmodic (relaxes GI tract and bladder), treats Parkinson's, extrapyramidal symptoms from other drugs, antitussive, lung and nasal congestion, overactive bladder and urinary incontinecne, motion sickness, as an antiemetic
- They are both subsets of the PNS. Somatic system covers all voluntary actions, i.e. input from the sense organs and output to skeletal muscles. Autonomic covers all involuntary actions, meaning input from internal receptors and output to smooth muscles and glands
- from the thoracic and lumbar areas of the spinal cord.
- CNS involves the brain and spinal cord, while PNS involves everything else but the brain and spinal cord... like sensory and motor neurons.
- They can inhibit gastric motility and can affect absorption of the drugs.
5 True/False Questions
What are the three main concerns about absorption with regard to drug-herb interactions? → pH: usually it takes a very acidic environment in the gut for drugs to be absorbed, gastric motility (need a rather slow peristalsis to give enough time for drugs to be absorbed)
reversible anticholinasterases → prevent cholinasterase from breaking acetalcholine down, so it stays in the cleft for longer and causes increased stimulation of the postsynaptic membrane receptors
ADR's of antimuscarinic agents → blurry vision, confusion, drowsiness, mydriasis (excessive dilation of the pupils), constipation, dry mouth, tachycardia, restlessness, headache, urinary retention
Neurotransmitter for Parasympathetic nervous system. → noradrenaline, why it is known as "Adrenergic nervous system"
How do herbs like E jiao and other gelatin based herbs affect the absorption of drugs → Can inhibit peristalsis, causing constipation