Mechanisms of Cell Injury and Ischemic/Hypoxic injury
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22 terms
Terms | Definitions |
|---|---|
 cell membranes | cell systems most vulnerable to injuries that induce necrosis |
| aerobic respiration | cell system most vulnerable to injuries that induce necrosis |
| synthetic appartatus | cell system most vulnerable to injuries that induce necrosis |
| genetic apparatus | cell system most vulnerable to injuries that induce necrosis |
| ATP deletion | common mechanism that induces necrosis |
| free radicals | common mechanisms that induces necrosis |
| membrane damage | common mechanism that induces necrosis |
| calcium influx | common mechanism that induces necrosis |
| Hypoxia/ischemia inhibit aerobic respiration | ATP deletion |
| generation of reduced oxygen species | free radicals |
| defects in the membrane permeability | membrane damage |
| disruption of Ca+ homeostasis | Ca++ influx |
| ribsome detachment | results in decreased protein synthesis which leads to lipid accumulation in cells |
| maintence of calcium gradient dependent on | Ca/Mg ATPases |
| hypoxia and other injury to membranes results in increased cytosolic Ca++ and activation of | phospholipase |
| hypoxia and other injury to membranes results in increased cytosolic Ca++ and activation of | ATPase |
| hypoxia and other injury to the membranes results in increased cytosolic Ca++ and activation of | protease |
| hypoxia and other injury to the membranes results in increased cytosolic Ca++ and activation of | endonuclease |
| most intracellular calcium is sequesterd in | mitochondria and ER |
| lack of oxygen | decreases mitochondrial aerobic respiration, slowing or stopping ATP generation |
| lack of ATP | induces the failure of Na:K pump in the cell membranes leading to an influx and acute cell swelling results |
| cellular pH decreases | leads to chromatin clumping |
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