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Movement of water across the membranes of cells, role of water in the body, chemical reactions within the body to maintain homeostasis

Role of water in the body

all water is used as a medium to carry solutes, like electrolytes and metabolites, throughout the body

Males contain how much water by weight?

65%

Women contain how much water by weight?

50%

How is water distributed throughout the body?

2/3 - intracellular compartments - inside cells
1/3 - extracellular compartments - outside cells

Examples of Extracellular compartments (ECF)

1. interstitial spaces
2. plasma
3. lymph
4. fluid in the eyes
5. synovial fluid in joint capsules
6. cerebrospinal fluid
7. serous fluids in cavities
8. lumens
9. glandular secretions - medium that carries hormones

Intracellular Fluids (ICF) contain what types of substances?

1. K⁺
2. Mg²⁺
3. PO₄³⁻
4. SO₂⁴⁻
5. Proteins

Extracellular Fluids (ECF) contain what types of substances?

1. Na⁺
2. Cl⁻
3. Ca²⁺
4. CO₂³⁻

Ions move by

1. diffusion
2. active transport
3. through protein channels or protein transporters

How does water shift with solute?

1. movement of solutes will shift water by osmosis
2. solvent drag - fluid will shift solutes

Daily water input

1500/3000mL/ day

Where do we get all that water from?

10% from metabolic reactions like aerobic respiration
90% from oral consumption

Thirst Reflex

- maintained by the Hypothalamus within Thirst Center that alerts the body for the need of water

Regulation of Thirst Reflex

1. Osmoreceptors - cells that monitor the osmolarity of bodily fluids
2. Baroreceptors - cells that monitor BP (↓BP will trigger thirst reflex to add more volume to blood)

How is thirst reflex suppressed?

stretching the stomach and moistening of oral mucosa will suppress thirst reflex immediately.

Increased H₂O Toxicity?

1. ↑ BP
2. bodily fluids dilute
3. ↓ in solute concentration

Dehydration

1. insufficient amounts of water either by lack of consumption, elevated temperatures, or high activity
2. ↓BP
3. body will compensate by removing H₂O out of ICF and into ECF

Water Output

1. 61% in urine
2. 4% in poop
3. 35% by respiratory tract (exhalation) and skin (sweat)

Perspiration

1. sweat glands, sudoriferous glands throughout our skin that excrete fluid by exocrine action.
2. excretory mechanism
3. shedds - NH₄, Urea, K⁺, and Na⁺ - forming acid mantle

Insensible Perspiration

1. tiny amounts of sweat shedding at all times
2. not noticeable
3. important for heat regulation
4. lowers body temperature
5. each day .5L of water is shed this way

Sensible Perspiration

1. ↑ temp will ↑ sweat by 100-150mL
2. Diaphoresis
3. associated withe exercise and hot environments
4. an increase in activity can increase visible sweat by 8-10L/day

Diaphoresis

visible sweat

Causes of body to ↑ Temp?

1. sexual arousal
2. emotional states
3. physical condition

Osmolarity of ECF

285 mOsm/ kg of tissue

Effect of ↑ Osmolarity

1. thirst reflex will trigger
2. ↑ ADH - acts on kidneys to retain water

Effect of ↓ Osmolarity

1. inhibits thirst reflex
2. ↓ ADH - water will be excreted in urine

Affects of BP on Osmolarity

1. ↑ BP will ↑ Glomerular Pressure to ↑ filtration, and pass out more water in urine which will lead to ↓ BP
2. ↓ BP which ↓ Glomerular which will ↓ filtration which will ↓ urine flow. A result is to trigger thirst reflex to ↑ BP.

Electrolytes

1. ions or molecules with electrical charges
ie) Na⁺, K⁺, Ca²⁺, Cl⁻, PO₄³⁻
2. electrolytes concentrations will change during weight changes and growing stages

How are electrolytes secreted?

by the kidneys, skin, and lungs

Where are electrolytes stored?

1. skeleton
2. mainly Ca²⁺ and PO₄³⁻
3. downfall is that bone can also store Pb, As, and Hg

Sodium

1. Cation in ECF
2. involved in sodium-potassium pump
3. vital for glucose absorption
4. essential for muscular contraction
5. Neurotransmitter
6. maintains pH balance with Cl⁻

Body's daily sodium requirement

1. <.5g/ day

how much do we actually consume?

1. 15-20g/ day
2. excess is removed via kidneys and sweat
3. regulated by ANH and Aldosterone

How does salt affect osmolarity?

↑ in salt requires an ↑ in water to balance osmolarity

Hyponatremia

1. Na⁺ deficiency

Causes of Hyponatremia

- poor diet
- severe burns
- vomiting
- diarrhea
- insufficient Aldosterone secretion
- excessive urination
- Hyperglycemia- ↑ blood sugar

Hyponatremia leads to

- lethargy
- disorientation
- nervous agitation
- seizures
- coma

Hypernatremia

elevated Na⁺ levels

Causes of Hyernatremia

- dietary
- hypersecretion of Aldosterone
- significant water loss

Hypernatremia leads to

- thirst
- dry mucous membranes
- ↑ body temperature
- hypertension
- bounding pulse
- tendencies toward edema
- convulsions
- death at extremely high Na⁺ levels

Chlorine

1. pH balancer in the body
2. Cl⁻ compounds activate digestive enzymes made of gastric juices
3. can be exhaled, excreted by the kidneys and skin

Chlorine Deficiency

1. causes - impaired digestion, vomiting, diarrhea
2. Leads to Blood Alkalosis

Potassium

1. Part of sodium -potassium pump
2. Neurotransmitter
3. Essential for muscular contraction
4. Dehydration, circulatory shock, and tissue damage can cause K+ to move out of cells and into ECF as a safeguard mechanism

Regulation of Potassium

1. Regulated by aldosterone - ↑ of aldosterone, ↑ kidney secretion of K+
2. Passes easily through filtration membrane - Primary Convoluted Tubule will reabsorb a lot of K+

Hypokalemia

insufficient Potassium

Causes of Hypokalemia

i. Diet (not enough fruits and vegetables with potassium)
ii. Renal failure
iii. Insulin administration

Hypokalemia leads to...

i. Poor skeletal health
ii. Bradycardia
iii. Heart blocks
iv. Decreased muscle tone

Hyperkalemia

elevated K⁺ levels

Causes of Hyperkalemia

1. Decreased renal excretion
2. Tissue trauma

Hyperkalemia leads to...

1. Restlessness
2. Irritability
3. Intestinal cramps
4. Diarrhea
5. Muscular weakness
6. Muscular paralysis - extremely elevated levels

Calcium

1. Managed by kidneys, intestines, skin (vitamin D Production), and skeleton
2. 99%of Ca2+ is stored in the skeleton
3. Vitamin D stimulates organs to absorb Ca2+
4. Essential for teeth and bones
5. Acid/base balancer
6. Essential for muscular regeneration

Parathyroid Hormones

1. Increases Ca2+ in ECF, stimulates kidneys to reabsorb Ca2+ from filtrate

Calcitonin

1. Antagonist to PTH
2. Hormone that decreases Ca2+ in the body by slowing down its release from bone

Regulation of Calcium

1. Parathyroid Hormone
2. Calcitonin

Hypocalcemia

insufficient Calcium

Causes of Hypocalcemia

i. Diet
ii. Low vitamin D levels
iii. Underactive Parathyroid

Hypocalcemia leads to

i. Disorientation
ii. Muscle spasms
iii. Frequent cramps
iv. Muscular weakness
v. Convulsions
vi. Tetani
vii. Osteoporosis
viii. Death

Hypercalcemia

elevated Calcium levels

Causes of Hypercalcemia

i. Overconsumption of Ca
ii. Excessive parathyroid activity - due to parathyroid cancers

Hypercalcemia leads to...

i. Fatigue
ii. Muscular weakness and response
iii. constipation
iv. coma
v. kidney stones
vi. death

pH of Bodily Fluids

a. acid base balance in the body is crucial to maintaining homeostasis
b. most human bodily fluids are between 6<pH<8

Buffer

compounds that regulate pH

Buffering Systems

i. Intercellular systems use proteins to buffer pH
ii.. Cations attract to OH-
iii. Anions attract to H+

H₂CO₃/HCO₃⁻

1. primary buffering system for ECF
2. Bicarbonate can absorb a H+ from fluid to form Carbonic Acid to stabilize pH
3. Carbonic acid can lose a H+ to form bicarbonate to stabilize pH

Phosphate Buffering System

a. H₂PO₄/HPO₄⁻

Ammonia Buffering System

NH₄/NH₃⁻

Alkalosis

- high pH levels - blood is more basic

Causes of Alkalosis

a. Overconsumption of Alkaline products - alcohol
b. Low atmospheric pressure of O2
c. Insufficient CO2 - Hypocapnia
d. Severe vomiting
e. Poisoning

Alkalosis leads to..

a. Hyper-excitability of NS
b. Muscular spasms
c. Convulsions
d. Tetani
e. Death

Acidosis

- low pH level - blood is too acidic

Causes of Acidosis

a. Toxin or drug ingestion
b. Decreased O2 perfusion
c. Increased CO2 levels
d. Problems in Diabetes - Increases glucose level
e. Accumulation of fatty acids
f. Bacterial infections - bacterial waste products

Acidosis leads to...

a. Depresses CNS
b. Disorientation
c. Slow responses
d. Blurred vision
e. Unconsciousness
f. Coma
g. death

Most common complications with electrolytes?

1. Hypernatremia
2. Hypokalemia
3. Hypocalcemia

pH of Blood

7.4

pH of Hydochloric Acid in the stomach

1<pH<2

Buffering systems that work in the Kidneys to regulate fitrate

1. Phosphate Buffering System
2. Ammonia Buffering System

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