Ross Immunology Overview of Hypersensitivity Reactions

Created by hbracken 

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Define allergen.

an antigen that causes IgE mediated hypersensitivity reaction.

Define allergy.

harmful antigen antibody reaction involving foreign antigen in food, pollen or chemical.

Define atopy.

hereditary tendency to develop IgE mediated allergic reactions to allergen that doesn't bother the normal individual.

Define anaphylaxis.

ana-against, phylaxis-protection. immediate hypersensitivity reaction from sensitization of tissue fixed mast cells by IgE.

Define anaphylactoid reaction.

anaphylaxis not of IgE origin. maybe by activation of complement - generation of anaphylatoxins C3a, C4a, C5a. cause degranulation of mast cells, release of vasoactive mediators.

Define sensitization.

allergic reaction require prior immunization by allergen that elicits the acute response.

Which hypersensitivity type is IgE mediated?

I

Which hypersensitivity type is cell mediated?

IV

Which hypersensitivity type is immune complex mediated?

III

Which hypersensitivity type is IgG or IgM mediated?

II

Which hypersensitivity type causes the Arthus reaction?

III

Which hypersensitivity type cause erythroblastosis fetalis?

II

Which hypersensitivity type causes serum sickness?

III

Which hypersensitivity type causes tubercular lesion?

IV

Which hypersensitivity type causes hay fever?

I

Which hypersensitivity type causes asthma?

I

Which hypersensitivity type causes autoimmune hemolytic anemia?

II

Which hypersensitivity type causes systemic lupus erythematosus?

III

Which hypersensitivity type causes graft rejection?

IV

Which hypersensitivity type causes contact dermatitis?

IV

Which hypersensitivity type causes necrotizing vasculitis?

III

Which hypersensitivity type causes blood transfusion reaction?

II

Which hypersensitivity type causes hives?

I

Which hypersensitivity type causes food allergies?

I

Which hypersensitivity type causes glomerulonephritis?

III

Which hypersensitivity type causes eczema?

I

Which hypersensitivity type causes systemic anaphylaxis?

I

Which hypersensitivity involves antibodies directed against cell surface antigens?

II

Which hypersensitivity involves antigen-antibody complex inducing complement activation and inflammatory response by massive infiltration of neutrophils?

III

Which hypersensitivity involves sensitized helper T cells that release cytokines that activate macrophages or cytotoxic T cells that mediate direct cellular damage?

IV

What hypersensitivity medial destruction via complement pathways or ADCC?

II

Which hypersensitivity involved antigen inducing cross-linking of Ig on mast cell or basophil that causes release of vasoactive mediators?

I

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