Histology Test 1

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Created by:

drakemc  on August 29, 2010

Subjects:

histology

Classes:

SGU SVM Class of 2016 (Jan 2012 entering class), SGU SVM Class of 2014 (August 2010 Entering Class)

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Histology Test 1

Surrounded by a cell membrane
Composed of nucleus, cytoplasm, organelles
What is a cell?
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Definitions

Surrounded by a cell membrane
Composed of nucleus, cytoplasm, organelles
What is a cell?
Measures 8-10 nm in width
Inner electron-dense lamina and electron-lucent intermediate layer
Hydrophyllic heads on outside and Hydrophobic tails oppose each other
Integral membrane proteins and peripheral membrane proteins
Has outer glycocalyx coat (glycolipid and glycoprotein)
Describe a cell membrane or plasmalemma.
1. Selective permeable
2. Receptor sites for antigens
3. Receptor sites for hormones
What are the functions of a cell membrane?
Skeletal muscle cells and osteoclasts Which cells contain more than one nucleus?
Mammalian erythrocytes lack nuclei Which cells have no nucleus?
25 nm-wide How thick is the nuclear envelope?
Chromatin arranged in basophilic clumps (mostly in inactive cells) What is heterochromatin?
Chromatin that is lightly stained and uniformly dispersed, (active form) What is euchromatin?
Sex chromatin, prominent in neutrophils of females What is a Barr body?
When the nucleus is euchromatic, suggestive of a lot of protein synthesis going on When can you see the nucleolus?
Only mature mammalian erythrocytes contain ribosomes Which cells do not contain ribosomes?
Protein synthesis What is the function of ribosomes?
produces secretory vesicles What is the function of Endoplasmic reticulum?
protein synthesis What is the roughER involved in?
synthesis of steroid hormones What is the smoothEF involved in?
Provides site for the accumulation, concentration and packaging of secretory proteins into membrane bound vesicles What is the function of the Golgi complex?
lysosome that gets rid of old or no longer active organelles What is an autophagosome?
lysosome that gets rid of foreign bodies What is a heterophagosome?
Contents of secondary lysosomes that accumulate in cells and can be used to tell cell age What is lipofuscin?
They synthesize and destroy hydrogen peroxide What do peroxisomes do?
Janus Green B What is mitochondria stained with?
Chief source of energy for the cell, indicates cell is active What is the function of mitochondria?
Microfilaments, intermediate filaments and microtubules embedded in the cytoplasmic matrix or cytosol What is the cytoskeleton composed of?
Endocytosis, exocytosis, and cell migratory activity What membrane activities are associated with microfilaments?
Provide strength and shape of the cell What do intermediate filaments do?
Important for transport of organelles and vesicles and cell division What do microtubules do?
Glycogen
Lipid
Melanin
Hemosiderin
Lipofuscin
What are some cytoplasmic inclusions?
Tight Junctions What type of junction is found in epithelial cells, has transmembrane proteins, and is common in the branching and reunited of blood vessels?
Zonula adherens, desmosomes or macula adherens, and hemidesmosomes What are the three Adhering junctions?
Cells held together by transmembrane protein, bundle of actin filaments run parallel to junctional cell membrane. Common in lining of intestines. What is a zonula adherens junction?
Strong junction with transmembrane proteins and intercellular electron-dense plaque. Intermediate filaments form hairpin loop What is a desmosome or macula adherens?
Cell to basement membrane connection What is a hemidesmosome junction?
Communicating (gap) junctions What junction permits direct passage of inorganic ions, bridged by interlocking transmembrane proteins and common in muscles?
Composed of nine doublet microtubules around two central microtubules. Found in respiratory and male and female system What is cilia and where is it found?
cytoplasmic evagination of cells to increase the free surface for absorption, found in small intestine What is the function of microvilli?
Long, rigid microvilli of the spiral organ (corti) of the inner ear, non-moving What are stereocilia?
Protection, absorption, secretion, and diffusion What are the functions of epithelium?
Lamina lucida, lamina densa (basalis), subbasal lamina What does the basement membrane consist of?
Simple epithelium What is a layer of epithelium that is a single layer?
Stratified epithelium What is a layer of epithelium that is two or more layers?
Simple squamous epithelium, common in blood vessels and liver epithelium What epithelium layer is single, thin and flat with the nucleus looking slightly elevated (bulging)?
Pseudostratified columnar epithelium, common in trachea and bronchi What epithelium layer is composed of a single layer of cells of different shapes giving the impression of stratified epithelium?
Stratified squamous epithelium, skin and cornea What epithelium is several layers thick with the most superficial being squamous?
lining of the excretory duct of glands Where is stratified cuboidal epithelium usually found?
parotid and mandibular gland ducts Where is stratified columnar epithelium usually found?
urinary bladder and urethra Where is transitional epithelium found?
Secretory epithelium and duct system (parenchyma) with supportive connective tissue (stroma) What is a gland?
Endocrine (ductless) and Exocrine (system of ducts) What are the two types of glands?
straight (large intestine)
coiled (sweat gland)
branched (stomach)
What are the three types of simple tubular glands?
sebaceous gland Where are simple alveolar or acinar glands found?
large sebaceous gland Where are simple branched acinar or alveolar glands found?
minor salivary gland of oral cavity Where are tubulo-acinar (alveolus) glands found?
compound tubular, compoud alveolar (parotid gland) and compound tubulo-alveolar (pancreas) What types of compound glands are there?
Serous glands These glands produce a thin, watery secretion.
Mucous glands These glands produce a thick, viscous (mucin) secretion.
Seromucous or mixed glands These glands have both serous and mucous acini.
secretory granules enclosed in a membrane, exocytosed What type of secretory release is merocine?
membrane bound granule with rim of cytoplasm and plasmalemma, released at apex of cell
e.g. sweat and mammary gland
What type of secretory release is apocrine?
entire cell is released as secretory product
e.g. sebaceous gland
What type of secretory release is holocrine?
Material is secreted from cell to the cytoplasm of another cell
e.g. transfer of melanin pigment
What type of secretory release is cytocrine?
Cells, fibers and amorphous ground substance What is connective tissue composed of?
Mesenchymal cells CT cells found adjacent to blood vessels
Irregularly shaped
Can differentiate into any other type of cell
Fibroblast cells Most common CT cells, active and quiescent forms
Responsible for synthesis of fibers
Wound repair
Myofibroblast Fibroblast cells that contain actin filament
Contraction during wound healing
Reticular cells Ct cells that are stellate-shaped
Spherical nucleus and basophilic cytoplasm
Produce reticular fibers
Unilocular adipocytes CT cells filled with large lipid droplets
Nucleus is displaced to periphery
Multilocular adipocytes CT cells filled with multiple lipid droplets
Nucleus is centrally located
"brown fat"
Pericytes Elongated CT cells located near the endothelium lining small blood vessels
Contain actin and myosin
Have potential to transform into other cells
Participate in healing
Mast Cells Common in loose CT and abundant around blood vessels
Stain red
Produce heparin (anticoagulant) and histamine
Plasma cells CT cells abundant in lymphatic tissues
Have spherical, eccentric nucleus (cart wheel like appearance)
Cytoplasm very basophilic
Macrophage CT cells that are phagocytic
Located in blood, migrate across blood vesel walls into CT
Contain cytoplasmic vacuoles and numerous lysosomes
pigment cells Cells containing pigment
Leucophytes White blood cells
Migrate through capillary walls to CT
tendon, ligament, and organ capsule Where are collagen fibers located?
Collagen fibers Most abundant fibers in mature CT
Made of fibrous protein
Strong and flexible but inelastic
Have a wavy arrangement
Reticular proteins These fibers form the framework of liver, endocrine, and lymphatic organs
Fibers are individual collagen fibrils (type III collagen) coated with proteoglycans and glycoproteins
Elastic fibers Fibers present in structures that require elasticity
Located in aorta, lungs, pinna of ear
Composed of elastin protein, covered by glycoprotein (fibrillin)
glycosaminoglycans (GAGs) and proteoglycans What is amorphous ground substance composed of?
Mesenchymal CT CT found in various types of adult CT, composed of mesenchymal cells and amorphous fluid-filled ground substance
Mucous or gelatinous CT CT found in umbilical cord and papillae of bovine glans penis, composed of stellate fibroblasts, AGS with collagen fibers
Loose or areolar CT CT found beneath epithelium, around blood vessels and nerves, and in serous membranes. Ground substance predominates
Dense CT CT found in tendons, ligaments, and aponeurosis, capsules of organs, and deep layer of the dermis
Elastic tissue CT found in nuchal ligament and vocal ligament, composed of elastic fibers
Reticular tissue CT found in spleen, lymph node, and liver
composed of reticular cells and reticular fibers
Adipose tissue CT found in loose CT of mesenteries and around blood vessels and nerves.
Composed of adipocytes
Cartilage CT tissue lacks blood vessels and is composed of cartilage cells
Chondroblast CT cells found in growing cartilage.
Oval shaped with a spherical nucleus
Chondrocyte CT cell located in the lacuna of cartilage
fibers and gound substance containing proteoglycans and GAGs. The matrix shows marked metachromasia What is the cartilage matrix composed of?
Articular surfaces of bones, nose and trachea Where is hyaline cartilage found?
Occur singly in a lacuna or in clusters called isogenous groups How are chondrocytes arranged in cartilage?
Pinna and epiglottis Where is elastic cartilage found?
Intervertebral discs and menisci and lacks a distinct perichondrium Where is fibrocartilage found?
Osteoblasts, osteocytes, and osteoclasts What are the three cell types in bones?
Osteoblast Bone forming cell that varies from columnar to squamous in shape and secretes osteoid.
Osteocytes Mature bones that lie in a lacuna.
Osteoclast A large multinucleated cell located in the area of bone resorption, bone eating cell
Consists of fibrous and osteogenic layers and lines outside of bone What is periosteum?
Lines the marrow cavity with a single layer of squamous cells What is endosteum?
Compact bone What type of bone forms the outer shells of the diaphysis and epiphysis?
Spongy bone What type of bone consists of delicate bony plates and spicules?
Compact bone What type of bone consists of haversian canals (osteons), circumferential lamellae, and interstitial lamellae?
Intramembranous ossification How are bones in the skull formed? (excluding the base of the skull)
Intracartilagenous or endochondral ossification How are most bones in the body formed?
Skeletal muscles What type of muscle tissue is striated, voluntary and have multiple oval nuclei located peripherally?
Cardiac muscle What type of muscle tissue is striated, involuntary, single nucleus, and Purkinje fibers?
Smooth muscle What type of muscle is non-striated, involuntary, and single nucleus?
Satellite cells What type of cells are located adjacent to myocytes and are activated upon injury to initiate some regeneration of muscle fibers?
Red muscle fibers What type of muscle fibers are known as slow twitch fibers (rich in myoglobin and mitochondria)?
White muscle fibers What type of muscle fibers are known as fast twich and have few mitochondria?
neurons and neuroglia What are the two types of cells that are in nervous tissue?
Brain and spinal cord The central nervous system is made up of _____ and ______.
cranial, spinal The peripheral nervous system is made up of _______ and _______ nerves.
visceral organs What does the autonomic nervous system innervate?
Layers that surround the central nervous system and roots of the peripheral nerves What are meninges?
Cavities of brain and spinal cord Where is CSF present?
Cell body (perikaryon) and nueronal processes (axon and dendrites) What makes up a neuron?
braind and spinal cord Where are multipolar neurons found?
bipolar cells of the retina Where are bipolar neurons found?
sensory ganglia Where are unipolar neurons found?
(also called pseudopolar neurons)
Cats and rodents In what animals is a sex chromatin evident in the vicinity of the nucleolus of a nerve cell body?
lipofuscin What pigments are residue of lysosomal activity and is used to tell age in nerve cells?
Nissl substance and numerous mitochondria What are some things commonly found in nerve cell cytoplasm?
Dendrites What processes of nerve cell bodies are devoid of golgi complexes, have a think band of electron dense material associated with plasmalemma, and have spines called gemmules?
chromatophilic substance (nissl substance) The axon cytoplasm is devoid of what?
neurotransmitter molecules stored within a synaptic vesicle What does each terminal branch of an axon (terminal bulb) contain?
Contact between two neurons or b/t neurons and effector cells What are synapses?
Axo-somatic
Axo-dendritic
Axo-axonic
What are the three types of synapses?
Gliocytes, provide structural and functional support What is another name for Neuroglial cells and what is their function?
Astrocytes
Oligodendrocytes
Microglial cells
Ependymal cells
Which neuroglial cells are in the CNS?
Neurolemmocytes (Shwann cells) which myelinate axons Which neuroglial cells are in the PNS?
Binds neurons to capillaries and the pia mater What is the function of astrocytes?
fibrous astrocytes What is the term for astrocytes in the white matter?
protoplasmic astrocytes What is the term for astrocytes in the grey matter?
Produces a meylin sheath which provides electrical insulation for neurons in the CNS What is the function of Oligodendrocytes?
Schwann cells, produce myelin sheaths in PNS What do neurolemmoctyes do?
Phagocytic cells derived from bone marrow What are microglial cells?
Facilitate the movement of CSF What is the function of ependymal cells?
Aggregations of nerve cell bodies along the course of peripheral nerves What are ganglia?
cranial nerves or dorsal root of spinal nerves, contain cell bodies of unipolar neurons What are sensory ganglia associated with?
accumulations of multipolar nerve cells along autonomic nerves, have eccentric nuclei What are autonomic ganglia?
Exteroreceptors (body surface), Enteroreceptors (viscera), and Proprioceptors (musculoskeletal structures) What are the three types of receptors by location?
Mechanoreceptors
Chemoreceptors
Thermoreceptors
What are the three types of stimulus?
40-50 nm What is the distance between a motor end plate and and the corresponding trough of the muscle sole plate in a neuromuscular synapse?
Patches of nerve cell bodies What does nuclei of the brain refer to?
Molecular layer
External granular layer
External pyramidal layer
Internal granular layer
Internal pyramidal layer
Fusiform layer
What are the layers of the cerebral cortex from outer layer to inner layer?
The grey is outside and the white inside How are the grey and white matter arranged in the cerebellum?
Outer molecular layer
Inner granular layer
Intermediate Purkinje cell layer
What are the three layers of the cerebellar cortex?
Subarachnoid space What space of the meninges is the CSF obtained from in an epidural?
Covering of the brain and spinal cord (dura mater, arachnoid and pia mater) What are the meninges?
Choroid plexus Where is the cerebrospinal fluid produced?

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