Ch3 - Antigen Recognition
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41 terms
Terms | Definitions |
|---|---|
 Ig (immunoglobulin), TCR (t-cell receptors) | What are the two main types of antigen receptors? |
| b cells, t cells | What type of cells make antigen receptors? |
| Ig, Ab | What type of antigen receptors do B cells have? |
| TCRs | What type of antigen receptors do t-cells have? |
| free or surface | Where are the receptors of b cells located? |
| surface | where are the receptors of t cells located? |
| bind specific molecules, edit genes, different types | What are three similarities of antigen receptors? |
| MADGE | What are the five Ig classes? |
| (Greek) ab, yd | What are the two types of TCRs? |
| ab | What is the more common type of TCRs? |
| somatic recombination | What is the process used by lymphocytes to edit their genes? |
| y | What is the shape of Igs / Abs receptors? |
| two I's | What is the shape of TCRs? |
| Igs, Abs | Which receptors can bind epitopes without help? |
| TCRs | Which receptors require MHC / APCs in order to bind epitope? |
| surface Igs, TCRs | Which receptors allow cells to recognize presence of antigen? |
| Abs | Which receptors neutralize or opsonize antigens? |
| two (light, heavy) | Antibodies have ___ amino acid chains |
| disulfide bond | What connects the two amino acid chains of antibodies? |
| Variable | the region of the antibody that is where the antigen binds. Specific. |
| Constant | the region of the antibody that engages the effector functions. Five main forms. |
| flexible | The hinge region of antibodies is ______ |
| isotype | the term for a "class" or group |
| no antigen presentation | What makes yd T cells unusual? |
| hypervariable | the region of the antibody that exists as loops at the tips. |
| linear | Which type of epitope can be taken out of context of a large antigen? |
| linear, discontinuous | what are the two types of epitopes? |
| electrostatic forces, h bonds, van der waals, hydrophobic forces | what holds antibody and antigen together? |
| MHC I or II | T cell receptors require that antigen be bound in _____ |
| peptides | What are presented by MHC I and II? |
| one | MHC I has __ transmembrane domain(s) |
| short | MHC I binds ____ peptides |
| two | MHC II has ___ transmembrane domain(s) |
| longer | MHC II binds _____ peptides |
| similar | What type of peptides does a given MHC I molecule bind? |
| varying | What type of peptides does a given MHC II molecule bind? |
| II | CD4 binds to MHC __ |
| I | CD8 binds to MHC __ |
| nucleated | MHC I is expressed on _______ cells |
| red blood | MHC I is not expressed on ______ cells |
| APCs, t | MHC II is expressed on _____ cells |
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