Erythropoiesis

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Erythropoiesis

identifies the entire process by which erythrocytes are produced in the bone marrow.

occurs in the medullary marrow over 5 days.

maturation results in reduction in cell volume, condensation of chromatin, decrease in N:C volume

Pronormoblast or Rubriblast

Primitive nucleus
(Erythropoiesis)
most primitive nucleus
1.5% in normal bone marrow
chromatin strands are dispersed
divides in 12hrs

Basophilic Normoblast, Prorubicyte

chromatin begins to condense
daughter cells of pronormoblasts
require20hrs to develop
1-5% in normal bone marrow

Polychromatophilic Normoblast

seek picture
smaller moer condensed chromatin in nucleus, cytoplasm mixed with pink or blue
normal adults 5-30% of bone marrow
not seen in peripheral blood
Erythropoiesis

Orthochromatic Normoblast or Meta Rubicyte

Metarubricyte matures in 48hrs into reticulocyte
degenerating nucleus with clumpled chromatin (pynotic)
nucleus is extruded
should only be found in newborns

Polychromatophilic erythrocyte or Reticulocyte

no nucleus
released from marrow into peripheral circulation 2-3 days
Erythropoiesis

Mature Erythrocyte

carries oxygen from the liungs to the tissues where it is exchanged for carbon dioxide

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