Skin, Soft Tissue, and Bone Infections

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Created by:

mgarfiel  on September 9, 2010

Subjects:

pharmacy

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Skin, Soft Tissue, and Bone Infections

primary SSTI
involve area of previously health skin, single pathogen
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Definitions

primary SSTI involve area of previously health skin, single pathogen
secondary SSTI occur in areas of previously damaged skin, polymicrobic
complicated SSTI involve deeper tissue, surgical intervention, immunosuppressed pts
erysipelas group a strep
impetigo staph aureus, group a strep
lymphangitis staph aureus, group a strep
cellulitis group a strep, s aureus, others
necrotizing fascitis type I anaerobes and facultative bacteria
necrotizing fascitis type II group a strep
honey colored crusty blisters, itchy impetigo
impetigo doc mupirocin (bactroban) for 7 days
augmentin 20 mg/kg/d x 7 days
sub q lymphatic inflammation lymphangitis
lymphangitis doc penicillin iv then pen vk 250-500 mg QID
pcn allergic pt with lymphangitis clindamycin 150-300 mg q6-8h
lymphangitis resembles this... dvt (streaking)
inflammation of the hair follicle (stye) folliculitis
boil or abscess, deeper than folliculitis, walled off mass furuncle
group of furuncles, deeper into subQ carbuncles
common bug for folliculitis, furuncle, carbuncles staph aureus
folliculitis tx warm, moist compresses, topical tx for 7 days
mupirocin
furuncle friction and perspiration, firm, tender red nodules
carbuncle broad, swollen, red, deep painful follicular masses
furuncle and carbuncle tx dicloxacillin (dynapen)
adults 250-500 mg QID
children 25-50 mg/kg/d QID
erysipelas st anthony's fire, beta hemolytic strep
well defined borders erysipelas
erysipelas DOC penicillin
cellulitis borders not well defined, complications common
cellulitis organisms staph aureus, strep pyogenes, CA MRSA
uncomplicated cellulitis dicloxacillin 500 mg QID
complicated cellulitis vancomycin
type I NF skin may be spared, destruct fat and fascia
type II NF strep gangrene
NF clindamycin and gentamycin
NF causes s pyogenes, group a strep
clostridial myonecrosis perfringens, PCN 20 mill u/d and clindamycin 300 mg QID
diabetic foot infections polymicrobial
PEDIS perfusion, extent, depth, involvement, sensation
grade 2 no MRSA cephalexin, dicloxacillin
HA MRSA linezolid, vanco, daptomycin
CA MRSA clindamycin, bactrim, doxy
grade 3/4 no MRSA ceftriaxone and clindamycin, zosyn, primaxin, etc
MSSA vanco, linezolid, daptomycin, synercid, tigecycline
pressure sore location 2/3 on feet and sacrum
bites polymicrobial
bites tx po augmentin
iv ampicillin/sulbactam: unasyn
osteomylitis infectious or septic arthritis
contiguous osteomyelitis adjoining soft tissue infection cause, 47%
hematogenous osteomyelitis spread through bloodstream, 19%
peripheral vascular disease 34%, distinct category, at risk
acute osteomyelitis under 1 week
chronic osteomyelitis > 1 month before initiation of therapy
contiguous osteomyelitis organisms s aureus most common, p aeruginosa, e coli, strep, staph, anaerobes

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