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Principles of Pharmacology and Autonomic Pharmacology: Lecture 2 Dr. Robert Rodgers

Drug-receptor complex

What does DR(e) respresent?

Drug molecules

What does D respresent?

Total Receptors

What does R(t) respresent?

True

True of false: The number of drug-receptor complexes is small compared to the total number of free drug molecules.

K(d)

What symbol represents the dissociation constant of the drug-receptor complexes? It is also known as the affinity constant.

False

True of false: The rate of association for drug-receptor complexes is greater than the rate of dissociation at equilibrium.

True

True of false: K(d) represents the concentration of drug necessary for that drug to bind to 50% of its available receptors

Spare receptors

A system is said to contain _____________ if a full response is reached without binding all of the receptors.

Inderal

What is one example of a medication that is a partial agonist? (It's a beta-blocker)

(D x R(t)) / (D + K(d))

Fill in the equation: DR(e) = ( __ x __ ) / ( __ + __ )

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