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path from genes to proteins

1. Transcription- enzymes use the base sequence of a gene to make a strand of RNA

2. Translation- Information in the RNA strand id decoded (translated) into a sequence of amino acids

3. Central Dogma of DNA to RNA to Protein

Central Dogma of DNA to RNA

1. Replication: DNA is replicated and passes on coded information
2. Transcription: Coded information is passed on to the RNA during transcription
3. Translation: Messenger RNA carries coded information to the ribosome during protein synthesis
4. Proteins provide structure and carry out almost all biological activity

Messenger RNA

Carries protein-building codes from DNA to ribosomes

Ribosomal DNA

(most abundant RNA in the cell)- Forms ribosomes where polypeptide chains are assembled

Transfer RNA

Delivers amino acids to ribsomes

RNA (structure and function)

sugar: Ribose
Bases: adenin-guanine/cytosine-uracil
Form: Single stranded
Function: disposable copies of heritable information

DNA (structure and function)

Sugars: deoxyribose
bases: adenine-guanine/cytosine-thynine
Form: Double-stranded helix
Function:Permanent storage of heritable information

Codon

Reading unit for translation machinery during translation
-starting codon is always AUG
-codons specify different amino acids

The Genetic Code

1. Messenger RNA carries DNA protein-building structures to ribosomes
2. Messenger RNA's messgae is written in codons

Three Stages of translation

1. initiation
2. Elongation
3. Termination

Mutations

_Mutations are permanent, small-scale changes in the base sequence of a gene

-Common mutations include insertions, delitions, and base-pair substitutions

Mitosis

(makes exact copies)- the basis of growth, cell replacement, and tissue repair in multicelled organisms
-the basis of asexual reproduction in single-celled and multicelled species

Meiosis

(Only in the context of sexual reproduction)
basis of sexual reproduction
reduces chromosome number by half to produce egg and sperm

Eukaryotic chromosomes

-association of DNA, histones, and other proteins
-proteins structurally organize the chromosome and affect access to its genes

Cell Cycle

1. New cell forms
2. Runs through Interphase
3. Ends when cell reproduces by nuclear and cytoplasmic division

Interphase

1. cell grows in mass and all cytoplasmic material is duplicated
2. DNA replication duplicates chromosomes
3. The cell prepares for division

Process of Mitosis

(a nuclear division method that maintains the chromosome number)
1. Prophase
2. Metaphase
3. Anaphase
4. Telophase

Prophase

1. duplicated chromosomes condense and prepare to form chromosomes
2. microtubules form a bipolar spindle
3.Nuclear envelope breaks down

Metaphase

1. Microtubules from one spindle pole harness one chromatid of each chromosome
2. microtubules from opposite poles then harness the sister chromatid
3. chromosomes are lined up in the middle of the cell

Anaphase

1. sister chromatids are detached from one another as the spindles move apart from each other
2. microtubules that overlap puch away from each other and spread the poles further apart

Telpophase

1. two identical clusters reach opposite poles
2. The nuclear envelope forms around each side
3. Both new nuclei have the parental chromosome number

Genes

sequences of DNA that encode heritable traits

Alleles

Slightly different forms of the same gene

Sexual Reproduction

-meiosis
-gamete formation
-fertilization

Meiosis

(nuclear division mechanism that precedes gamete formation in Eukaryotic cells and halves the parental chromosome number)

Fertilization

forms zygote (first cell of new individual)
Restores parental chromosome number

Meiosis I

-the first nuclear division
-each duplicated chromosome lines up with its homologous partner
-the two homologous chromosomes move apart, toward opposite spindle poles

Meiosis II

-The second nuclear division
- Sister chromatids are pulled away from each other
- Each is now an individual chromosome

prophase I

The first phase of meiosis I. During prophase I the replicated chromosomes condense, homologous chromsomes pair up, crossing over occurs between homologous chromosomes, the spindle is formed, and the nuclear envelope breaks apart into vesicles. Prophase I is the longest phase of meiosis.

Metaphase I

The second phase of meiosis I. During metaphase I the paired homologous chromsomes (tetrads) align at the center of the cell (the metaphase plate).

Anaphase I

The third phase of meiosis I. the replicated homologous chromosomes are separated (the tetrad is split) and pulled to opposite sides of the cell.

Telophase I

The fourth of meiosis I. the number of chromosoms is now reduced by half. After this phase the cell is considered to be haploid. Note however, that the chromosomes are still replicated, and the sister chromatids must still be separated during meiosis II.

Prophase II

The first phase of meiosis II. identical to the mitotic step, except that the number of chromosomes was reduced by half during meiosis I.

Metaphase II

The second phase of meiosis II. identical to the mitotic step, except that the number of chromosomes was reduced by half during meiosis I.

Anaphase II

- sister chromatids are pulled to opposite poles by the spindle fibers

Telophase II

4 cell results....each cell is haploid with unreplicated chromosomes

Variation during Meiosis

1. Crossing over during prophase 1
2. Chromosome shuffling during metaphase 1
3. Chance meeting of gametes at fertilization

Origin of Species Book was Published in....

1859

Evidence of Evolution

The fossil Record
Genetics
Geological time scale

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