RED BLOOD CELLS

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RBC and Platelet maturation,Morphology, inclusions and Anemia

Erthropoietin

hormone secreted by kidneys for the formation of RBCs---- released during anermia

Splenic contraction

significant, allows horses to have more speed, rbc stored here, circulate in spleen, caue fight or flight response, RBC can be damaged here

RBC function

transports O2 from the lungs to the tissues and carbon dioxide from tissues to lungs

hemoglobin

iron-containing protein in red blood cells that carries oxygen for delivery to cells

methemoglobin

An altered hemoglobin which does not carry oxygen.before the liver can convert back to hemoglobin

MCV

Mean corpuscular volume average volume of RBCs; useful for anemia classification

MCH

mean corpuscular hemoglobin

MCHC

mean corpuscular hemoglobin concentration

erythropoiesis

the process of producing red blood cells by the stem cells in the bone marrow

Rubriblasts

Step 1 large solid nucleus w/ little cyto (stains guite dark), for every stem cell, there is one of these cells, split into 2 prorubricytes

Prorubricyte

Step 2 : 2 cells form from the division of a rubriblast (cell size dec., nucleus size decreases, (cytoplasam matures and becomes lighter) has to end up w/ no nucleus

Rubricyte

Step 3. in RBC pathway. Cell undergoes 3 mitotic divisions. Cell size decreases, nuclear size decreases, and cytoplasm matures.

Metarubricyte

Step 4. and contains a very dense nucleus (nRBC)

57%-67%

What percent in a dz animal where there be metarubricytes?

Erythrocyte

a mature blood cell that contains hemoglobin to carry oxygen to the bodily tissues

Platelets

thrombocytes; cell fragments in the blood essential for blood clotting (coagulation)

Megakaryoblasts

build mature plateletes

Anisocytosis

Unequal sized RBC's

polychromasia

condition of many colors; clinically means erythrocytes with varies or multicolored staining qualities

hypochromasia

No color in cell due to inuffeicient Hb with in the cell. Low Iron.

Discocyte

Biconcave Disc, normal RBC

Normocytic

A normal sized Erythrocyte....

normochromic

pertaining to normal concentration of hemoglobin (colour)

Microcytosis

Small RBC's, anemia's with decreased MCV, observed normal in Asian dogs

Macrocytosis

A condition anemia where there is interference with nucleic acid synthesis inhibiting cell division (vitamin B12 / folic acid def)min. poodles and malamutes and the cell is bigger.

hypochromasia

red blood cells that have a decreased red color, iron deficiency, lead toxicity

polychromasia

condition of many colors; clinically means erythrocytes with varies or multicolored staining qualities

poikilocytosis

abnormal variations in the shapes of RBC (poikilo 5 variation)

codocytes

aka target cells associated with liver dz, and anemia

stomatocytes

malamutes, min. schnauzers, artifact

Eccentrocytes or torocytes

Shifting of Hb to one side of the cell, resulting in a clear zone outlined by membrane

ovalocyte

shaped like an oval membrane defect

dacryocyte

tear drop cell - fragmentation disease

Schistocytes

Fragmented of a RBC, DIC!!!!,CHF DEATH IS COMING

acanthocytes

RBC's w/ rounded projections (irregular borders) seen in pigs

echinocyte

abnormal red blood cell with a burr (spiny) appearance. Artifacts due to Creanation in smear.

spherocytes

Spher chaped . Microcytic, hyperchromic, associated with autoimmune hemoltic anemia.AIHA

Burr cells

Renal Dz and lipidosis elongated echinocytes

Ghost cells

remnant of cell membrane. no hemoglobin

agglutination

clumping of blood cells

anemia

a deficiency of red blood cells

anemia

polychromasia,reticulocytosis,anisocytosis ,nRBC,Howell-jolly bodies are signs of this condition.

basophilic stippling

What is the term for cytoplasmic remnants of RNA in RBCs, seen in lead poisoning?

Relative

Dehydration, red blood count the same for pcv is what kind of polycythemia?

Primary

myeloprolifirative disorder, production of too many red blood cells by the BONE MOARROW,is what kind of polycythemia?

2nd

REDUCED O2, increased erythropoeitin levels.HR DZ, pneumonia. and renal dz is what kind of polycythemia?

Polychromatiphil

They are reticulocytes when stained with new methylene blue

Lead Poisoning

This erythrogram would include basophilic stippling with marked nRBC's and minimal polychromasia.

polycythemia

an excessive or abnormal increase in the number of erythrocytes

Eosinophilic

As a erythrocyte matures, the cytoplasm changes color from basophilic to what?

megakaryocyte

The only cell to become larger as it matures.

Aggregate

When counting retic's in cats, we only count what on the reticulocytes?

Echinocyte

Crenation is a type of Echinocyte.

Schistocyte

A RBC fragment is called what?

Rouleaux

RBC abnormality characterized by coin like stacks

Agglutination

Abnormality that is characterized by grape like clusters of RBC's that due not break up when diluted.

Cat

Who has the shorter RBC life span Dog or Cat?

Renal Failure

The lowest circulating erythropeoitin concentration would be found in animals with what type of chronic problem

Compensatory

Tachycardia,Tachypnea, splenic contraction, and movement of interstitial fluid to the vascular space are all what kind of mechanism.

Agglutination

This would be indicative of immune-mediated hemolysis.

PCV

A low blood to aticoagulant ratio would cause a false reading in what?

Heinz bodies

Precipitated denatured hemoglobin in red cells may be referred to what?

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