Alterations in Hemostasis

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Chapter 10

thrombocytopenia

Decrease in the number of circulating platelets. Usually caused by diseases of the bone marrow.

Idiopathic Thrombocytopenic Purpura

An autoimmune disorder that results in platelet antibody formation and the destruction of platelets.

Hemophilia A

X-linked recessive disorder. Primarily affects men. Low level of Factor VIII.

Von Willebrand Disease

Reduced platelet adhesion. Deficiency/defect of vW factor. Autosomal trait.

Disseminated Intravascular Coagulation

Widespread coagulation and bleeding in the vascular compartment.

thrombopoietin

Made in liver, kidney, smooth muscle, bone marrow.

megakaryocytes

Formed in bone marrow. Break apart to form many platelets.

platelets

Stored in spleen. Live 8-9 days in circulation. Released when needed.

coagulation factors

plasma proteins- most syntesized by the liver.

von Willebrand factor

Coagulation factor made by endothelium.

hemostasis

vasoconstriction, formation of platelet plug, blood coagulation, clot retraction, clot dissolution

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