| Term | Definition |
|---|
| Naloxone | Narcan |
| Naloxone | Nal...,synthetic opioid; mu, kappa, and delta antagonist; reverses opioid overdose |
| Nalmefene | Opioid.Nal... |
| Nalmefene | Revex. |
| Naltrexon | Revia |
| Naltrexon | Opioid. Nal... |
| Digoxinfab | or Digibind. Digoxin,Digitoxin. |
| Leucovorin | or Wellcovorin. Methrotrexate, Trimethoprim, Pyrimethamine. Effectively aborts MTX toxicity by supplying reduced folate to cells |
| Methotrexate | Inhibits dihydrofolate reducatase (DHFR), Rheumatrex, antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases such as ankylosing spondylitis, Crohn's disease, psoriasis, psoriatic arthritis, and rheumatoid arthritis. |
| Trimethoprim | Name the antimicrobial agent, alter folate metabolism. A drug that acts along with sulfonamides to fight UTIs |
| Pyrimethamine | protozoal infections. It is commonly used as an antimalarial drug |
| Mesna | Cyclophosphamide, Ifosfamide. |
| Cyclophosphamide | Antineoplastic, Alkylating Agents Prodrug activated by P450, suppresses B and T cells (B cells more b/c slower rate of recovery) Used for autoimmune diseases (hemolytic anemia, systemic lupus, r. arthritis, wegeners granulomatosis) and organ transplant |
| Ifosfamide | nitrogen mustard alkylating agent used in the treatment of cancer • Cyclophosphamide derivative used for testicular cancer |
| Vitamin K | A fat-soluble vitamin that helps in the clotting of blood found in green leafy veg. Antidote for Coumadin. |
| Protamine | An agent that reverses the effects of heparin. |
| Deferoxamine | or Desferal.Used to treat acute iron toxicity |
| Dimercaptol-quelating agent | Arsenic, Gold. |
| Sodium Thiosulfate | Cyanide. |
| Flumazenil | or Romazicon. antagonizes benzodiazepines and zolpidem |
| Physostigmine | or Antilirium. Atropine.Anticholinergic. |
| Acetylcysteine | or Mucomyst. Acetaminophen. |
| Dexrazoxane | or Zinecard. Doxorubicin., Iron chelator that inhibits free radical formation and can be used to reduce cardiac damage |
| Doxorubicin | antitumor antibiotic - inserts between DNA bases and induces DNA strand breaks, Doxil.CHF or cardiac heart failure. |
| Pralidoxime | or Protopam. Organophosphorus compound. |
| Glucagon | Insulin |
| Edetate Calcium disodium | Lead |
| Atropine | Acetyl choline, Cholinergic agent |
| Hydroxocobalamin | Cyanide. |
| Hydroxocobalamin | vitamin B-12, with folic acid essential cofactors required for DNA synthesis.Used in Pernicious anemia. |
| Anticholinergic toxidrome | blurred vision, coma, decreased bowel sounds, mydriasis (dilated pupils), seizures, and urinary retention. Complications include hypertension, hyperthermia, and tachycardia |
| Anticholinergic toxidrome | antihistamines, atropine, benztropine, tricyclic antidepressants, and scopolamine (from datura). |
| Cholinergic toxidrome | A mnemonic is SLUDGE- Salivation, Lacrimation, Urination, Diaphoresis (excessive sweating), Gastrointestinal distress, and Emesis. Plus miosis. |
| Cholinergic toxidrome | carbamates, mushrooms, and organophosphates |
| hallucinogenic toxidrome | disorientation, hallucinations, hyperactive bowel sounds, panic, and seizures. Complications include hypertension, tachycardia, and tachypnea |
| hallucinogenic toxidrome | amphetamines, cocaine, and phencyclidine. |
| Opiate toxidrome | altered mental states, miosis, shock, and unresponsiveness. Complications include bradycardia, hypotension, hypothermia, shallow respirations, and a slow respiratory rate |
| Opiate toxidrome | dextromethorphan, opiates, and propoxyphene |
| Sedative/hypnotic toxidrome | ataxia (gross incoordination of muscle movements), blurred vision, coma, confusion, delirium, deterioration of central nervous system functions, diplopia (double vision), dysesthesias (unpleasant abnormal sensation), hallucinations, nystagmus, paresthesias (numbness of a person's skin), sedation, slurred speech, and stupor. Apnea is a potential complication |
| Sedative/hypnotic toxidrome | anticonvulsants, barbiturates, benzodiazepines, and ethanol |
| Sympathomimetic toxidrome | anxiety, delusions, diaphoresis (excessive sweating), hyperreflexia, mydriasis, paranoia, piloerection, and seizures. Complications include bradycardia, hypertension, and tachycardia |
| Sympathomimetic toxidrome | albuterol, amphetamines, cocaine, ephedrine, methamphetamine, phenylpropanolamine (PPA's), and pseudoephedrine |
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