METABOLISM + NUTRITION

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Created by:

LauraCC  on October 26, 2010

Subjects:

human biology

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METABOLISM + NUTRITION

functions of food
to supply energy
to build and maintain body tissues
to regulate body processes
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Terms

Definitions

functions of food to supply energy
to build and maintain body tissues
to regulate body processes
nutrients required by body water
carbs
lipids
proteins
minerals
vitamins
nutrition processes by which food is taken in, assimilated, and turned into tissue and usable material for growth and energy
difference between essential +
non-essential nutrients
essential nutrients are not syntesized in the body

non-essential nutrients can be made from other nutrients
glycogenesis conversion of glucose to glycogen for storage
gluconeogenesis formation of glucose from protein or fat compounds
anabolism synthesis by cells of complex compounds from simpler compounds
metabolism sum total of chemical reactions that occur within the body
catabolism breakdown of complex compounds into simpler compounds
glucose principle source of energy for cells
glycolysis first step in the catabolism of glucose
where first step of glucose metabolism occurs cytoplasm
where remaining steps of metabolism occur mitochondria
enzymes compounds that catalyze glucose metabolism reactions
hormones involved in glucose metabolism insulin
glucogen
epinephrine
growth hormone
glucocorticoids
thyroid hormone
calorie (kilocalorie) energy content of foods
definition of calorie amount of heat necessary to raise the temperature of 1 kilogram of water 1 degree C
under what conditions is basal metabloic rate BMR measured? awake but resting
postabsorptive state (12-18 hrs after last meal)
in a comfortable warm environment
how AGE affects BMR BMR increases to age 5
decreases thereafter
how SEX affects BMR males have higher BMR than females
how BODY SIZE affects BMR greater amount of surface area requires a higher BMR
how CAFFEINE affects BMR increases BMR
how PREGNANCY affects BMR increases BMR
how FEVER affects BMR increases BMR
how THYROID HORMONE affects BMR increases BMR
factors that determine total metabolic rate *basal metabolic rate BMR
*voluntary work
*specific dynamic action of foods
*environmental temperature
specific dynamic action of foods the energy needed for metabolizing foods causes the metabolic rate to increase for several hours after a meal
area of brain important in regulating food intake hypothalamus
regions of hypothalamus that have a
direct influence on food intake
feeding center and satiety center of hypothalamus
most essential nutrient for body water
extracellular fluid fluid within the body but outside the cells
dehydration condition resulting from excessive loss of water
interstitial fluid fluid between the cells
intracellular fluid fluid within the cells
approximate percentage of body weight in water 60%
functions of water in the body -solvent
-transportation of materials
-removing body waste
-regulation of body temp
-metabolic processes
amount of water lost daily + must be replaced about 2 1/2 - 3 liters
sources of water liquids
foods
metabolism
how water is lost lungs (respiration)
perspiration
feces
urine
the order water loss occurs from the
fluid compartments of the body
1. plasma
2. interstitial fluid
3. intracellular fluid
more common danger --
overhydration or dehydration?
dehydration
4 calories/gram carbs
proteins
9 calories/gram lipids
broken down to monosaccharides carbohydrates
broken down to amino acids proteins
broken down to fatty acids + glycerol lipids
can supply the body with energy carbs
lipids
proteins
chemical composition of carbohydrates carbon
oxygen
hydrogen
chemical composition of fats carbon
oxygen
hydrogen
chemical composition of proteins carbon
oxygen
hydrogen
nitrogen
glucose monosaccharide
fructose monosaccharide
galactose monosaccharide
lactose disaccharide
maltose disaccharide
sucrose disaccharide
cellulose polysaccharide
glycogen polysaccharide
starch polysaccharide
complex carbohydrates naturally occurring carbohydrates
refine carbohydrates processed carbohydrates -- nutrients have been lost
end result of CARBOHYDRATE catabolism carbon dioxide
water
energy
end result of CARBOHYDRATE anabolism glycogen (stored in liver and muscles)
triglycerides (stored in adipose tissue)
table sugar sucrose
milk sugar lactose
animal starch glycogen
non-digestible carbohydrate cellulose
form or carb stored in body glycogen
form of carb carried in blood glucose
compound formed from carbs for
storage in adipose tissue
triglycerides
why fiber is necessary in human diet necessary for proper functioning of digestive tract
problems linked to diet
lacking in fiber
constipation
appendicitis
diverticulosis
colon cancer
saturated fats have single bonds between carbon atoms
unsaturated fats have one or more double bonds
(therefore, saturated fats hold more hydrogen atoms)
major source of saturated fats foods of animal origin
major source of unsaturated fats foods of plant origin
type of fat: CORN OIL unsaturated
type of fat: LARD saturated
type of fat: SUNFLOWER OIL unsaturated
type of fat: BUTTER saturated
type of fat: CREAM saturated
type of fat: OLIVE OIL unsaturated
process that converts saturated fat to
unsaturated fat
hydrogenation
end result of LIPID catabolism -fatty acids

-glycerol, which can be oxidized to yield CO2, water, energy

-ketone bodies, which can be oxidized to yield CO2, water, energy
result of accelerated fat catabolism ketogenesis

*occurs during starvation, diabetes mellitus, fasting, dieting
ketogenesis symptoms *ketosis (elevated ketone bodies in blood)
*acetone breath
*ketonuria (ketone bodies present in urine)
products of LIPID synthesis triglycerides
cholesterol
phospholipids
prostaglandins
necessary component of lipid synthesis
that cannot be produced by the body
essential fatty acids (unsaturated fatty acids)
forms in which lipids are transported by blood -chylomicrons
-lipoproteins
-free fatty acids
product of lipid synthesis that is
stored in adipose tissue
triglycerides
small at droplets present in blood
during fat absorption
chylomicrons
produced mainly in liver lipoproteins
blood levels of this increase whenever
rate of fat catabolism increases
free fatty acids
LDLs low density lipoproteins
"bad" cholesterol
HDL high density lipoproteins
"good" cholesterol
lipid components of lipoproteins triglycerides
cholesterol
phospholipids
good lipoproteins HDLS
type of lipoproteins that increase
with diet high in saturated fats
LDLs
lipoproteins associated with
high incidence of atherosclerosis
LDLs
lipoproteins increased by exercise HDLs
lipoproteins increased by smoking LDLs
essential amino acid cannot be synthesized by body
complete proteins have all the essential amino acids present
incomplete proteins lack one or more of the essential amino acids
major source of complete proteins foods of animal origin
major source of incomplete proteins foods of plant origin
complementary proteins combining incomplete proteins to supply the body with the essential amino acids

the amino acids missing from the proteins of one are supplied by the proteins of another
primary in protein metabolism:
anabolism or catabolism?
anabolism
primary in carbohydrate metabolism:
anabolism or catabolism?
catabolism
primary in lipid metabolism:
anabolism or catabolism?
catabolism
result of protein anabolism synthesis of tissue proteins, blood proteins, enzymes, hormones, etc.
component of protein anabolism that
cannot be synthesized by body
essential amino acids (8 of them)
first step in protein catabolism deamination
deamination splitting off of an amino group (NH2) from an amino acid molecule
products of deamination ammonia and keto acid
end results of protein catabolism *ammonia is converted to urea and excreted in urine

*keto acid may be oxidized to yield CO2, water, and energy
or:
- converted to glucose (gluconeogenesis), or:
- converted to fat (lipogenesis)
equation for cellular respiration C6 H12 O6 =
6O2 ------enzymes-----> 602 + 6H2O + ATP
calorie deprived condition, starvation marasmus
condition caused by
protein deficiency
kwashiorkor
nutrients that regulate body processes proteins
minerals
vitamins
nutrients that supply body with energy carbs
lipids
protein
end products of catabolism CO2 - excreted by lungs

water - excreted by lungs, kidneys, small intestine

urea - excreted by kidneys
function of CARBOHYDRATES supply energy
function of LIPIDS supply energy
build + maintain body tissues
function of PROTEINS build + maintain body tissues
regulate body processes
supply energy
recommended % of daily calories
from CARBOHYDRATES
60%
recommended % of daily calories
from LIPIDS
30%
recommended % of daily calories
from PROTEINS
10%
functions of minerals build and maintain body tissues
regulate body processes
function of vitamins regulate body processes
macro minerals required in amounts of 100 mg/day or more
trace (micro) minerals required in amounts less than 100 mg/day
fat soluble vitamins A
D
E
K
water soluble vitamins B-complex
C
vitamins stored in body tissues fat soluble
(A, D, E, K)
vitamins excreted in urine water soluble
(B-complex, C)
vitamins destroyed by light water soluble
(B-complex, C)
good sources for IRON liver, meats, poultry, fish, legumes, dried fruits, eggs
good sources for VITAMIN A liver, milk, cheese, eggs, dark green + yellow/orange veggies, fruits
good sources for VITAMIN C citrus fruits, many other fruits and veggies
good sources for CALCIUM dairy products, leafy vegetables, sardines
good sources for SODIUM table salt, widespread in natural + processed foods
good sources for FLUORINE fluoridated drinking water, tea, fish
good sources for VITAMIN D sunlight on skin, fish liver oils, eggs, fortified foods
good sources for IODINE iodized salt, seafood
good sources for PHOSPHORUS dairy products, whole grains, legumes, nuts, fish, poultry, eggs
good sources for
B-COMPLEX VITAMINS
whole grains, meats, fish, poultry, leafy vegetables
good sources for VITAMIN B12 all animal products, especially liver
deficiency of thiamine (B1) beriberi
deficiency of ascorbic acid (C) scurvy
deficiency of calcium osteoporosis
deficiency of niacin pellagra
deficiency of vitamin D rickets
deficiency of iodine goiter
deficiency of fluorine dental caries
deficiency of vitamin B12 pernicious anemia
deficiency of calcium tetany
deficiency of iron nutritional anemia
deficiency of vitamin A night blindness
deficiency of vitamin D osteomalacia
deficiency of vitamin K, calcium poor blood clotting
deficiency of riboflavin (vitamin B2) lesions of mouth and tongue
result of over-consumption of vitamins various toxicities, especially of fat soluble vitamins (because they are stored in body tissues)
toxicities identified with too much
of these vitamins
A
D
E
Niacin (a B vitamin)
4 basic food groups milk
meat
fruit + vegetable
breads + cereals
adult RDA for milk group 2 servings
adult RDA for meat group 2 servings
adult RDA for fruit & vegetable group 4 servings
adult RDA for bread & cereal group 4 servings
1 serving from
milk group
8 oz glass milk
1 c yogurt
1 1/2 oz cheese
1 serving from
meat group
2-3 oz meat, poultry, fish
2 eggs
1 c cooked beans
4 T peanut butter
1/2 c nuts/seeds
1 serving from
fruit & vegetable group
1 med size piece fruit
1 c raw veggies
1/2 c cooked veggies
1/2 c juice
1 serving from
bread & cereal group
1 slice bread
1/2 c cooked cereal
1/2 c cooked pasta
1 c ready to eat cereal
RDA "recommended daily allowances"

safe and adequate amounts of specific nutrients (1980 list has 18) are established for 15 categories of individuals according to sex + age, with separate amounts established for pregnant or lactating women
organization that sets forth RDAs Food and Nutrition Board of Nat'l Research Council
reviewed every 5 years
avitaminosis K vitamin K deficiency

impaired blood-clotting
occurs in children
beriberi vitamin B1 (thiamine) deficiency

peripheral nerve condition - diarrhea, fatigue, anorexia, edema, heart failure, limb paralysis, muscle atrophy
folate-deficiency anemia folic acid deficiency

blood disorder - decreased RBC count
iron-deficiency anemia iron deficiency

blood disorder - decreased size + pigmentation of RBCs
kwashiorkor protein-calorie malnutrition

adequate calories, deficient protein
marasmus protein-calorie malnutrition

deficient calories AND protein - true malnutrition
nyctalopia - night blindness vitamin A deficiency

failre to produce enough photopigment in rods of retina
osteomalacia vitamin D, CA, and/or phosphorus deficiency - ADULTS

adult form of rickets - reduced mineralization of bone tissue - softening of bones
pellagra vitamin B3 (niacin) or tryptophan (amino acid) deficiency

sun-sensitive scaly dermatitis, confusion, depression
pernicious anemia vitamin B12 deficiency

blood disorder - reduced # of RBCs - weakness, tingling, anorexia
PCM -- protein-calorie malnutrition dietary deficiency of calories, esp protein

i.e. kwashiorkor + marasmus
rickets vitamin D, Ca, and/or phosphorus deficiency - KIDS

juvenile form of osteomalacia - weakness + abnormal skeltal formation due3 to reduced mineralization of bone tissue
scurvy vitamin C deficiency

reduced manufacture and maintenance of collagen - weakness of gingiva, loosening of teeth, hemorrhaging (esp in skin and mucous membranes)
simple goiter iodine (I) deficiency

enlarged thyroid tissue b/c without iodine, thyroid is unable to make thyroid hormone - low thyroid hormone levels trigger hypersecretion of thyroid-stimulating hormone TSH by pituitary, which stimulates thyroid growth
zinc deficiency zinc deficiency

impaired healing + immunity, decreased alertness, smell, and taste, retarded growth
glycolysis breakdown of glycogen to glucose

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