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Skeletal, Cardiac, & Muscle Tissue Derived From mesoderm Dilator Papillae in Eye Derived From Neuroectoderm (Optic Cup of The Diencephalon Satallite Cells (~Myoblasts) Regenerate muscle fiber Desmin Intermediate microfilament in cytoplasm of sacromere betwn. Z lines -->Joins adjacent Z lines of the sacromere at the same level -->Keeps neigboring sacromeres aligned with each other Trypsin Cuts heavy chain of myosin into 2 parts Papin Cuts hinge portion of myosin into 2 parts Myofibroblast Contain actin and myosin for contraction; Typically seen in wound contraction to decr. size of opening Titin Attaches thick filaments on Z line to prevent excess streching Nebulin Achors thin filaments to Z line Alpha-Actin Actin-binding protein that forms the Z-Line C Protien ("Myosin bending protein") Forms strips on the M Line Creatine Kinase Present at M Line; Helps provide supply of ATP from ADP Duchenne's Muscular Dystrophy Dystrophin absent in cytoplasm of inner surface of cell membrane -->Cannot attach sacromere to CT to tendon to provide a contractile force Botulism Toxin produced by Clos. Botulinum bacteria which inteferes with the release of Ach, leading to muscle paralysis Myasthenia Gravis An autoimmune disorder, characterized by muscle weakness -->Autoantibodies attach to Ach Receptors, inhibiting Ach to bind to it -->Neuromuscular damage gravitates from head to toe Muscle Spindle Specialized strech receptor within skeletal muscle -->Involved in proprioception -->Contain intrafusal fibers, involved in knee jerk rxn. Cardiac Muscle Derived from splanchnic mesoderm Zona Adheren's in Transverse Portion of Interclated Disk Attaches thin filaments in the terminal sarcomere (~to Z-Line) Oxytocin Can Induce smooth muscle contraction in the wall of the uterus, especially during childbirth and breast feeding Myoepithelial Cells Contractile, non-epithelial cells NOT DERIVED FROM MESODERM -->Originate from ECTODERM -->Involved in glandular secretory units (Ex. mammary units, lacriminal glands)