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Non specific present at birth do not discriminate specific defenses many develop after the birth with exposure to pathogens; protection is specific to particular threat 1st line of defense skin and mucous membranes Skin acid secretion-acid mantle 2nd line of defense phagocytes, microphages, macrophages and natural killer cells, interferons, complement system, inflammatory response, fever Phagocytes engulf, digest, remove debris and pathogens Microphages neutrophils, eosinphils, basophils..enter infected injured areas Macrophages -monocytes, free and fixed; found in every tissue; in brain=microglia -patrol healthy tissues neutrophils abundant, quickly mobilized-attack cellular debris or bacteria eosinophil less abundent-attack pathogens that have been coded with antibodies Neutrophils steps Diapedesis, chemotaxis, phagocytosis Diapedesis squeeze between adjacent and epithelial cells chemotaxis attracted by chemicals phagocytosis to eat cell and digest NAtural killer cells destroy abnormal cells, immunological surveillance, kill infected cell SLOWS spread of infection, prevents spread of cancer natural killer cells recognize infection via viral proteins on cell surface nk 1 NK cells contacts virus infected cell nk 2 Nk cells release pore forming proteins nk 3 PFPs inserted into plasma membrane of virus infected cell nk 4 pores form- result in perforations/holes nk 5 virus infected cell lysed nk 6 macrophages engulf/digest debris