Chapter 9

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Created by:

Hipkotch  on November 11, 2010

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cell 1010 exam 3

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Chapter 9

cell communication
gives cells capacity to sense changes in its environment, isolates cell, allows division of function in multicellular organisms
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cell communication gives cells capacity to sense changes in its environment, isolates cell, allows division of function in multicellular organisms
signals agents that cause changes in properties of cells
receptors present on plasma membrane-- receptors of signals relay message to cell by conformational change
nitric oxide signal causes contraction of muscles
ethaneen signals fruit to ripen
direct intracellular signaling cells are directly in contact, there is no space between them, called gap junctions in animal cells
contact dependent signaling some molecules are bound to the surface of cells to serve, signal can not move it is bound to targeting signal, i.e. red blood cells
autocrine signaling singal will bind to receptors of itself and also to receptors of cells of the same type, when cell is ready to divide autocrine signal will dignal division or arrestation, is secreted into fluid
paracrine signaling localized, short lived, synaptic gap, signal is secreted in synaptic gap to come in contact w/ other cells
endrocrine signaling lipid soluable agents that can't be broken down, long signals, e.g. etholene
3 stages of cell signaling see microsoft
Ligand signaling molecule, binds non covalently to receptor with high degree of specificity, binding and release between receptor and ligand is relatively rapid, induces conformational change, sometimes you need certain concentration
Enzyme linked receptors not only recieves signal, functions as catalyst, binds in extracellular environment, intracellular domain is where catalysis takes place
Kinase cerine, threonynin, can phosphorylate themselves or other compounds or both-- indoing so activate the cell
G protein coupled receptors passes through membrane 7x, is on cytosolic side of plasma membrane, bound to guansyndisphosphate or guanosyntriphosphate
g protein binding process see microsoft
ligand gated ion channels is receptor, not facilitated diffusion, don't have to pay attnetion to gradients, allows ions to bind to change conformation, has 2 binding sights, found along nerve cells and muscle cells
intracellular receptors inside cytosol of the nucleus
estrogens interaction with intracellular receptors see microsoft
auxins interaction with intracellular receptor see microsoft
signal transduction and cellular response see microsoft
enzyme linked kynases phosphate to themselves, to others, or transfer from themselves to others
protein kinase cascade see microsoft
second messengers ion or molecules that relay message in to cell, convert intracellular messages to intra cellular membrane, examples are ca+, CAMP, inositol triphosphate & diacylglycerol
difference between cAMP and AMP bound to 5th and 3rd carbon, not just 5th
signal transduction via CAMP see microsoft
2 advantages of cAMP as messengers signal amplification, spped
signal transduction via ca2+ membrane bound organelles have high concentration, calcium enters through pump to to higher concentration by primary active transport or secondary active transport
see microsoft
Epinephrinan example of signal transduction bia calcium channels, different effects throughout the body, heart muscle cells, contraction controled by calcium channells, calcium stored in sarcoplasmic reticulum, binds to troponin leading to muscle contraction, dropping calcium causes muscle to relax through phosphorylation, quick series of contraction to relaxation in fight or flight mode, hense increased cardiac rhythm.
Caffiene has ability to deactive phosphodyaspherase which removes cAMP therefore our body thinks epinephrine is present, or behaves as though it is

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