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5 Written Questions

5 Matching Questions

  1. NSAID Drugs
  2. Trastuzumab
  3. Etanercept
  4. Dexamethasone
  5. Cyclophosphamide
  1. a DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis
  2. b Corticosteroid
    Immunosuppressant
    Long-action
    MOA: DMARD
    Tox: DMARD
  3. c Soluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis
  4. d Aspirin
    Ibuprophen
    Naproxene
    Celecoxib
  5. e Cancer Treatment
    MOA: HER2/neu, Growth Factor receptor
    Clical Uses: Breast Cancer

5 Multiple Choice Questions

  1. Calcineurin Inhibitor
    MOA: prevents IL2/IL-2 receptor production
    Clinical Uses: prevetion of graft rejection, not reverse graft rejection
    Tox: Reversible B-lympoproliferatie disorders, Nephrotoxic
  2. Leukemia/lymphoma therapy
    MOA: anti CD33 w/calicheamicin. Binds CD33+ cells Drug is internalized binds to DNA resulting in DNA double stranded breaks and cell death
  3. Lymphocyte Trafficking Inhibitors
    MOA:alpha-4 integrin blocks vascular adhesion molecuels prevents T lymphocyte entry into brain or gut
    Clinical Uses: Relapsing MS, Crohns Disease
    Adverse Effects: Risk ofr multi focal leukoencephalopathy
  4. IL-2
    TNF-a
    GM-CSF
    IL-3
    IL-4
    IL-5
    CXCL8
  5. Immunosuppresant for Organ Transplantation
    MOA: IL2r, CD25
    Clinical Uses: Allograft rejection
    GVHD

5 True/False Questions

  1. OmalizumabImmunosupressant
    MOA: IgE antagonist
    Clinical Uses: Asthma

          

  2. FingolimodLymphocyte Trafficking Inhibitors
    MOA: Prodrug, Phosphorylated by sphingosine kinase
    Blocks lymphocyte from exiting lymph nodes causes lymphopenia
    Targets CD4>CD8>b-cells
    Clinical Uses: Relapsing MS, Taken Orally
    Adverse Effect: Bradycardia, Opportunistic infections

          

  3. TacrolimusmTOR inhibitor
    MOA: Inhibits T-cell proliferation
    binds FKBP-12 and inhibits mTOR pathway
    Blocks IL-2 signalling
    Clinical Uses: prevention of renal transplant rejection
    Adverse Effects: Nephrotoxicity, Hypercholestrolemia, Hyper triglyceridemia, mylosuppression

          

  4. MethotrexateSoluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis

          

  5. DMARD clinical Usesprevention of acute allograft rejection
    Treatment of all inflammatory conditions
    Short-term anti-inflammatory

          

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