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5 Written questions

5 Matching questions

  1. NSAIDS clinical Uses
  2. Dexamethasone
  3. Chlorambucil
  4. Tacrolimus
  5. DMARD Toxcities
  1. a Osteoporosis
    Neuropsychiatric
    Cushingoid appearance
    impaired glucose metab
    cataract glaucoma
    Skin thinning
    cardiovascular
  2. b Inflammatory conditions
    Not for transplantation
  3. c Corticosteroid
    Immunosuppressant
    Long-action
    MOA: DMARD
    Tox: DMARD
  4. d DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis
  5. e Calcineurin Inhibitor
    MOA: binds FK protein inhibits IL-2 Secretion and other cytokines
    Clinical Use: Prevention/Rejection of organ transplantation
    Toxcities: Nephrotoxic, Diabetes, peripheral neuropathy

5 Multiple choice questions

  1. DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis
  2. IL-2
    TNF-a
    GM-CSF
    IL-3
    IL-4
    IL-5
    CXCL8
  3. Aspirin
    Ibuprophen
    Naproxene
    Celecoxib
  4. reduce inflammation
    target non-specifc inflammtory cells
    overlapping therapuetic goals
    Not-immunosuppressive
    inhibits PG synthesis
    inhibits COX1/COX2 activity
    no effect on T/B cells
  5. inhibits transcription of inflammatory mediators
    Increase some anti-inflammatory regulator genes
    Decrease production of cytokines
    Reduced expression of adhesion molecules =decreased leukocyte adhesion

5 True/False questions

  1. AnkinraIL-1 cytokine antagonist
    Soluable Ligand Receptor Drugs
    MOA: sIL1 receptor antagonist
    Clinical Uses: RA

          

  2. PrednisoneCorticosteroid
    Immunosuppressant
    Long-action
    MOA: DMARD
    Tox: DMARD

          

  3. SirolimusmTOR inhibitor
    MOA: Inhibits T-cell proliferation
    binds FKBP-12 and inhibits mTOR pathway
    Blocks IL-2 signalling
    Clinical Uses: prevention of renal transplant rejection
    Adverse Effects: Nephrotoxicity, Hypercholestrolemia, Hyper triglyceridemia, mylosuppression

          

  4. EtanerceptSoluable Ligand/Receptor Drugs
    MOA: Soluable CTLA4-Ig, competitive inhibitor of CD28
    prevents co-stimulatory CD80/86
    Prevents T-cell activation and cytokine release
    Clinical Uses: Treatment of Rheumatoid Arthritis

          

  5. OmalizumabImmunosupressant
    MOA: IgE antagonist
    Clinical Uses: Asthma

          

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