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5 Written Questions

5 Matching Questions

  1. Tacrolimus
  2. Dexamethasone
  3. Natalizumab
  4. Prednisone
  5. Daclizumab
  1. a Corticosteroid
    Immunosuppressant
    Long-action
    MOA: DMARD
    Tox: DMARD
  2. b Calcineurin Inhibitor
    MOA: binds FK protein inhibits IL-2 Secretion and other cytokines
    Clinical Use: Prevention/Rejection of organ transplantation
    Toxcities: Nephrotoxic, Diabetes, peripheral neuropathy
  3. c Corticosteroid
    Immunosuppressant
    Short-duration
    MOA: converted in-vivo to prednisolone
    DMARD Tox
  4. d Immunosuppresant for Organ Transplantation
    MOA: IL2r, CD25
    Clinical Uses: Allograft rejection
    GVHD
  5. e Lymphocyte Trafficking Inhibitors
    MOA:alpha-4 integrin blocks vascular adhesion molecuels prevents T lymphocyte entry into brain or gut
    Clinical Uses: Relapsing MS, Crohns Disease
    Adverse Effects: Risk ofr multi focal leukoencephalopathy

5 Multiple Choice Questions

  1. MOA: MMF converted in-vivo to mycophenolic acid
    Inhibits T/B cell proliferation
    Prevents DNA synthesis by inhibiting IMP-DH prevents guanosine nucleotide production
    Clinical Uses: Prevention of GVHD
    graft rejection
    Lupus nephritis
    Toxcities: Diarrhea, vomitting, nausea, meylosupression
    Contraindication: Hepatic Insufficiency
  2. IL-2
    TNF-a
    GM-CSF
    IL-3
    IL-4
    IL-5
    CXCL8
  3. DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis
  4. reduce inflammation
    target non-specifc inflammtory cells
    overlapping therapuetic goals
    Not-immunosuppressive
    inhibits PG synthesis
    inhibits COX1/COX2 activity
    no effect on T/B cells
  5. Soluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis

5 True/False Questions

  1. AbataceptSoluable Ligand/Receptor Drugs
    MOA: Soluable CTLA4-Ig, competitive inhibitor of CD28
    prevents co-stimulatory CD80/86
    Prevents T-cell activation and cytokine release
    Clinical Uses: Treatment of Rheumatoid Arthritis

          

  2. Calcineurin Inhibitors MOAreduce inflammation
    target non-specifc inflammtory cells
    overlapping therapuetic goals
    Not-immunosuppressive
    inhibits PG synthesis
    inhibits COX1/COX2 activity
    no effect on T/B cells

          

  3. DMARD ToxcitiesOsteoporosis
    Neuropsychiatric
    Cushingoid appearance
    impaired glucose metab
    cataract glaucoma
    Skin thinning
    cardiovascular

          

  4. RituximabLeukemia/lymphoma Therapy
    MOA: CD20 binding, Blocks Ca2+ channel on B-cell
    Clinical Uses: CLL, B-cell lymphoma

          

  5. FingolimodLymphocyte Trafficking Inhibitors
    MOA: Prodrug, Phosphorylated by sphingosine kinase
    Blocks lymphocyte from exiting lymph nodes causes lymphopenia
    Targets CD4>CD8>b-cells
    Clinical Uses: Relapsing MS, Taken Orally
    Adverse Effect: Bradycardia, Opportunistic infections

          

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