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5 Written questions

5 Matching questions

  1. Cyclosporin
  2. DMARD Toxcities
  3. Infliximab
  4. Rituximab
  5. Chlorambucil
  1. a Osteoporosis
    Neuropsychiatric
    Cushingoid appearance
    impaired glucose metab
    cataract glaucoma
    Skin thinning
    cardiovascular
  2. b TNF antagonist
    Immunosuppresant
    MOA: TNF targeting
    Clinical Uses: Crohns disease, RA, Ulcerative Colitis,
  3. c Calcineurin Inhibitor
    MOA: prevents IL2/IL-2 receptor production
    Clinical Uses: prevetion of graft rejection, not reverse graft rejection
    Tox: Reversible B-lympoproliferatie disorders, Nephrotoxic
  4. d Leukemia/lymphoma Therapy
    MOA: CD20 binding, Blocks Ca2+ channel on B-cell
    Clinical Uses: CLL, B-cell lymphoma
  5. e DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis

5 Multiple choice questions

  1. Immunosuppresant for Organ Transplantation
    MOA: IL2r, CD25
    Clinical Uses: Allograft rejection
    GVHD
  2. Corticosteroid
    Immunosuppressant
    Long-action
    MOA: DMARD
    Tox: DMARD
  3. Leukemia/lymphoma therapy
    MOA: anti CD33 w/calicheamicin. Binds CD33+ cells Drug is internalized binds to DNA resulting in DNA double stranded breaks and cell death
  4. Lymphocyte Trafficking Inhibitors
    MOA:alpha-4 integrin blocks vascular adhesion molecuels prevents T lymphocyte entry into brain or gut
    Clinical Uses: Relapsing MS, Crohns Disease
    Adverse Effects: Risk ofr multi focal leukoencephalopathy
  5. inhibits transcription of inflammatory mediators
    Increase some anti-inflammatory regulator genes
    Decrease production of cytokines
    Reduced expression of adhesion molecules =decreased leukocyte adhesion

5 True/False questions

  1. AzthioprineIL-1 cytokine antagonist
    Soluable Ligand Receptor Drugs
    MOA: sIL1 receptor antagonist
    Clinical Uses: RA

          

  2. Mycophenolate MofetilDNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis

          

  3. DenileukinLeukemia/lymphoma therapy
    Conjugate
    MOA: IL2+Diptheria toxin fusion protein. Binds to IL2r+ cells
    Toxins prevent protein synthesis and cell death
    Clinical Uses: cutaneous T-cell Lymphoma

          

  4. Calcineurin Inhibitors MOAreduce inflammation
    target non-specifc inflammtory cells
    overlapping therapuetic goals
    Not-immunosuppressive
    inhibits PG synthesis
    inhibits COX1/COX2 activity
    no effect on T/B cells

          

  5. NSAID Drugsreduce inflammation
    target non-specifc inflammtory cells
    overlapping therapuetic goals
    Not-immunosuppressive
    inhibits PG synthesis
    inhibits COX1/COX2 activity
    no effect on T/B cells

          

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