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Immunopharmacology TUCOM Test

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5 Written Questions

5 Matching Questions

  1. Denileukin
  2. Cyclophosphamide
  3. Etanercept
  4. Methotrexate
  5. Rituximab
  1. a Leukemia/lymphoma Therapy
    MOA: CD20 binding, Blocks Ca2+ channel on B-cell
    Clinical Uses: CLL, B-cell lymphoma
  2. b Cytotoxic Drug
    MOA: Folic acid antagoinst
    Clinical Uses: Rheumatoid arthritis Gold standard drug
  3. c DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis
  4. d Soluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis
  5. e Leukemia/lymphoma therapy
    Conjugate
    MOA: IL2+Diptheria toxin fusion protein. Binds to IL2r+ cells
    Toxins prevent protein synthesis and cell death
    Clinical Uses: cutaneous T-cell Lymphoma

5 Multiple Choice Questions

  1. Inflammatory conditions
    Not for transplantation
  2. Immunosuppresant for Organ Transplantation
    MOA: IL2r, CD25
    Clinical Uses: Allograft rejection
    GVHD
  3. Lymphocyte Trafficking Inhibitors
    MOA: Prodrug, Phosphorylated by sphingosine kinase
    Blocks lymphocyte from exiting lymph nodes causes lymphopenia
    Targets CD4>CD8>b-cells
    Clinical Uses: Relapsing MS, Taken Orally
    Adverse Effect: Bradycardia, Opportunistic infections
  4. Soluable Ligand/Receptor Drugs
    MOA: Soluable CTLA4-Ig, competitive inhibitor of CD28
    prevents co-stimulatory CD80/86
    Prevents T-cell activation and cytokine release
    Clinical Uses: Treatment of Rheumatoid Arthritis
  5. inhibits transcription of inflammatory mediators
    Increase some anti-inflammatory regulator genes
    Decrease production of cytokines
    Reduced expression of adhesion molecules =decreased leukocyte adhesion

5 True/False Questions

  1. Calcineurin Inhibitors MOAprevent Ca2+ binding to calcineurin
    black signal transduction pathway
    Prevents IL-2 produciton
    Prevents T-cell proliferation
    B cell phagocyte function spared

          

  2. NSAID DrugsAspirin
    Ibuprophen
    Naproxene
    Celecoxib

          

  3. SirolimusmTOR inhibitor
    MOA: Inhibits T-cell proliferation
    binds FKBP-12 and inhibits mTOR pathway
    Blocks IL-2 signalling
    Clinical Uses: prevention of renal transplant rejection
    Adverse Effects: Nephrotoxicity, Hypercholestrolemia, Hyper triglyceridemia, mylosuppression

          

  4. DexamethasoneCorticosteroid
    Immunosuppressant
    Short-duration
    MOA: converted in-vivo to prednisolone
    DMARD Tox

          

  5. DMARD clinical UsesInflammatory conditions
    Not for transplantation

          

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