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5 Written Questions

5 Matching Questions

  1. Abatacept
  2. Cyclophosphamide
  3. Methotrexate
  5. Etanercept
  1. a DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    Myasthenia Gravis
  2. b Soluable Ligand/Receptor Drugs
    MOA: Soluable CTLA4-Ig, competitive inhibitor of CD28
    prevents co-stimulatory CD80/86
    Prevents T-cell activation and cytokine release
    Clinical Uses: Treatment of Rheumatoid Arthritis
  3. c reduce inflammation
    target non-specifc inflammtory cells
    overlapping therapuetic goals
    inhibits PG synthesis
    inhibits COX1/COX2 activity
    no effect on T/B cells
  4. d Cytotoxic Drug
    MOA: Folic acid antagoinst
    Clinical Uses: Rheumatoid arthritis Gold standard drug
  5. e Soluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis

5 Multiple Choice Questions

  1. TNF antagonist
    MOA: TNF targeting
    Clinical Uses: Crohns disease, RA, Ulcerative Colitis,
  2. Lymphocyte Trafficking Inhibitors
    MOA: Prodrug, Phosphorylated by sphingosine kinase
    Blocks lymphocyte from exiting lymph nodes causes lymphopenia
    Targets CD4>CD8>b-cells
    Clinical Uses: Relapsing MS, Taken Orally
    Adverse Effect: Bradycardia, Opportunistic infections
  3. IL-1 cytokine antagonist
    Soluable Ligand Receptor Drugs
    MOA: sIL1 receptor antagonist
    Clinical Uses: RA
  4. Leukemia/lymphoma therapy
    MOA: anti CD33 w/calicheamicin. Binds CD33+ cells Drug is internalized binds to DNA resulting in DNA double stranded breaks and cell death
  5. prevent Ca2+ binding to calcineurin
    black signal transduction pathway
    Prevents IL-2 produciton
    Prevents T-cell proliferation
    B cell phagocyte function spared

5 True/False Questions

  1. DexamethasoneCorticosteroid
    MOA: converted in-vivo to prednisolone
    DMARD Tox


  2. NSAIDS clinical Usesprevention of acute allograft rejection
    Treatment of all inflammatory conditions
    Short-term anti-inflammatory


  3. TacrolimusCalcineurin Inhibitor
    MOA: binds FK protein inhibits IL-2 Secretion and other cytokines
    Clinical Use: Prevention/Rejection of organ transplantation
    Toxcities: Nephrotoxic, Diabetes, peripheral neuropathy


  4. NSAID DrugsAspirin


  5. TrastuzumabCancer Treatment
    MOA: HER2/neu, Growth Factor receptor
    Clical Uses: Breast Cancer


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