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5 Written questions

5 Matching questions

  1. Tacrolimus
  2. Cytokines Effected by DMARDS
  3. Ankinra
  4. Gemtuzumab
  5. NSAIDS MOA
  1. a reduce inflammation
    target non-specifc inflammtory cells
    overlapping therapuetic goals
    Not-immunosuppressive
    inhibits PG synthesis
    inhibits COX1/COX2 activity
    no effect on T/B cells
  2. b Calcineurin Inhibitor
    MOA: binds FK protein inhibits IL-2 Secretion and other cytokines
    Clinical Use: Prevention/Rejection of organ transplantation
    Toxcities: Nephrotoxic, Diabetes, peripheral neuropathy
  3. c IL-1 cytokine antagonist
    Soluable Ligand Receptor Drugs
    MOA: sIL1 receptor antagonist
    Clinical Uses: RA
  4. d Leukemia/lymphoma therapy
    MOA: anti CD33 w/calicheamicin. Binds CD33+ cells Drug is internalized binds to DNA resulting in DNA double stranded breaks and cell death
  5. e IL-2
    TNF-a
    GM-CSF
    IL-3
    IL-4
    IL-5
    CXCL8

5 Multiple choice questions

  1. Calcineurin Inhibitor
    MOA: prevents IL2/IL-2 receptor production
    Clinical Uses: prevetion of graft rejection, not reverse graft rejection
    Tox: Reversible B-lympoproliferatie disorders, Nephrotoxic
  2. Corticosteroid
    Immunosuppressant
    Short-duration
    MOA: converted in-vivo to prednisolone
    DMARD Tox
  3. Immunosuppresant for Organ Transplantation
    MOA: IL2r, CD25
    Clinical Uses: Allograft rejection
    GVHD
  4. Aspirin
    Ibuprophen
    Naproxene
    Celecoxib
  5. Soluable Ligand/Receptor Drugs
    MOA: Soluable CTLA4-Ig, competitive inhibitor of CD28
    prevents co-stimulatory CD80/86
    Prevents T-cell activation and cytokine release
    Clinical Uses: Treatment of Rheumatoid Arthritis

5 True/False questions

  1. DMARD ToxcitiesOsteoporosis
    Neuropsychiatric
    Cushingoid appearance
    impaired glucose metab
    cataract glaucoma
    Skin thinning
    cardiovascular

          

  2. AzthioprinePurine Antagonist
    MOA: pro-drug 6-mercaptopurine
    Clinical Uses: Tx of Rheumatoid Arthritis Anti-inflammatory, graft rejection
    Adverse Effects: Myelosuppression, Dose dependent, Neutropenia, thrombocytopenia
    Contra-Indication: current infection
    pancreatitis

          

  3. DenileukinLeukemia/lymphoma therapy
    MOA: anti CD33 w/calicheamicin. Binds CD33+ cells Drug is internalized binds to DNA resulting in DNA double stranded breaks and cell death

          

  4. EtanerceptSoluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis

          

  5. SirolimusmTOR inhibitor
    MOA: Inhibits T-cell proliferation
    binds FKBP-12 and inhibits mTOR pathway
    Blocks IL-2 signalling
    Clinical Uses: prevention of renal transplant rejection
    Adverse Effects: Nephrotoxicity, Hypercholestrolemia, Hyper triglyceridemia, mylosuppression

          

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