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5 Written questions

5 Matching questions

  1. DMARD clinical Uses
  2. Fingolimod
  3. Omalizumab
  4. Gemtuzumab
  5. Chlorambucil
  1. a prevention of acute allograft rejection
    Treatment of all inflammatory conditions
    Short-term anti-inflammatory
  2. b Immunosupressant
    MOA: IgE antagonist
    Clinical Uses: Asthma
  3. c Leukemia/lymphoma therapy
    MOA: anti CD33 w/calicheamicin. Binds CD33+ cells Drug is internalized binds to DNA resulting in DNA double stranded breaks and cell death
  4. d DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis
  5. e Lymphocyte Trafficking Inhibitors
    MOA: Prodrug, Phosphorylated by sphingosine kinase
    Blocks lymphocyte from exiting lymph nodes causes lymphopenia
    Targets CD4>CD8>b-cells
    Clinical Uses: Relapsing MS, Taken Orally
    Adverse Effect: Bradycardia, Opportunistic infections

5 Multiple choice questions

  1. Corticosteroid
    Immunosuppressant
    Long-action
    MOA: DMARD
    Tox: DMARD
  2. Purine Antagonist
    MOA: pro-drug 6-mercaptopurine
    Clinical Uses: Tx of Rheumatoid Arthritis Anti-inflammatory, graft rejection
    Adverse Effects: Myelosuppression, Dose dependent, Neutropenia, thrombocytopenia
    Contra-Indication: current infection
    pancreatitis
  3. Cancer Treatment
    MOA: HER2/neu, Growth Factor receptor
    Clical Uses: Breast Cancer
  4. mTOR inhibitor
    MOA: Inhibits T-cell proliferation
    binds FKBP-12 and inhibits mTOR pathway
    Blocks IL-2 signalling
    Clinical Uses: prevention of renal transplant rejection
    Adverse Effects: Nephrotoxicity, Hypercholestrolemia, Hyper triglyceridemia, mylosuppression
  5. Soluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis

5 True/False questions

  1. RituximabTNF antagonist
    Immunosuppresant
    MOA: TNF targeting
    Clinical Uses: Crohns disease, RA, Ulcerative Colitis,

          

  2. NSAID Drugsreduce inflammation
    target non-specifc inflammtory cells
    overlapping therapuetic goals
    Not-immunosuppressive
    inhibits PG synthesis
    inhibits COX1/COX2 activity
    no effect on T/B cells

          

  3. CyclophosphamideDNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis

          

  4. Calcineurin Inhibitors MOAprevent Ca2+ binding to calcineurin
    black signal transduction pathway
    Prevents IL-2 produciton
    Prevents T-cell proliferation
    B cell phagocyte function spared

          

  5. InfliximabTNF antagonist
    Immunosuppresant
    MOA: TNF targeting
    Clinical Uses: Crohns disease, RA, Ulcerative Colitis,

          

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