NAME

Question types


Start with


Question limit

of 30 available terms

Advertisement Upgrade to remove ads
Print test

5 Written questions

5 Matching questions

  1. Ankinra
  2. NSAIDS MOA
  3. Cytokines Effected by DMARDS
  4. Calcineurin Inhibitors MOA
  5. Omalizumab
  1. a IL-2
    TNF-a
    GM-CSF
    IL-3
    IL-4
    IL-5
    CXCL8
  2. b prevent Ca2+ binding to calcineurin
    black signal transduction pathway
    Prevents IL-2 produciton
    Prevents T-cell proliferation
    B cell phagocyte function spared
  3. c Immunosupressant
    MOA: IgE antagonist
    Clinical Uses: Asthma
  4. d reduce inflammation
    target non-specifc inflammtory cells
    overlapping therapuetic goals
    Not-immunosuppressive
    inhibits PG synthesis
    inhibits COX1/COX2 activity
    no effect on T/B cells
  5. e IL-1 cytokine antagonist
    Soluable Ligand Receptor Drugs
    MOA: sIL1 receptor antagonist
    Clinical Uses: RA

5 Multiple choice questions

  1. Purine Antagonist
    MOA: pro-drug 6-mercaptopurine
    Clinical Uses: Tx of Rheumatoid Arthritis Anti-inflammatory, graft rejection
    Adverse Effects: Myelosuppression, Dose dependent, Neutropenia, thrombocytopenia
    Contra-Indication: current infection
    pancreatitis
  2. Osteoporosis
    Neuropsychiatric
    Cushingoid appearance
    impaired glucose metab
    cataract glaucoma
    Skin thinning
    cardiovascular
  3. Leukemia/lymphoma therapy
    Conjugate
    MOA: IL2+Diptheria toxin fusion protein. Binds to IL2r+ cells
    Toxins prevent protein synthesis and cell death
    Clinical Uses: cutaneous T-cell Lymphoma
  4. Soluable Ligand/Receptor Drugs
    MOA: Soluable CTLA4-Ig, competitive inhibitor of CD28
    prevents co-stimulatory CD80/86
    Prevents T-cell activation and cytokine release
    Clinical Uses: Treatment of Rheumatoid Arthritis
  5. Leukemia/lymphoma Therapy
    MOA: CD20 binding, Blocks Ca2+ channel on B-cell
    Clinical Uses: CLL, B-cell lymphoma

5 True/False questions

  1. InfliximabLeukemia/lymphoma Therapy
    MOA: CD20 binding, Blocks Ca2+ channel on B-cell
    Clinical Uses: CLL, B-cell lymphoma

          

  2. SirolimusmTOR inhibitor
    MOA: Inhibits T-cell proliferation
    binds FKBP-12 and inhibits mTOR pathway
    Blocks IL-2 signalling
    Clinical Uses: prevention of renal transplant rejection
    Adverse Effects: Nephrotoxicity, Hypercholestrolemia, Hyper triglyceridemia, mylosuppression

          

  3. EtanerceptSoluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis

          

  4. FingolimodmTOR inhibitor
    MOA: Inhibits T-cell proliferation
    binds FKBP-12 and inhibits mTOR pathway
    Blocks IL-2 signalling
    Clinical Uses: prevention of renal transplant rejection
    Adverse Effects: Nephrotoxicity, Hypercholestrolemia, Hyper triglyceridemia, mylosuppression

          

  5. DexamethasoneCorticosteroid
    Immunosuppressant
    Long-action
    MOA: DMARD
    Tox: DMARD

          

Create Set