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5 Written questions

5 Multiple choice questions

  1. mediated by impaired supply of glucose to brain over extended period of time, following gradual decline in blood glucose concentration, does not elicit epinephrine response, brain cell malfunction when deprived of glucose, cognitive behavior affected, have slurred speech, confusion, seizures, may have coma leading to death if not corrected, slow decline in blood glucose level without sudden release of epinephrine
  2. indicative of reactive hypoglycaemia, sulphonylurea overdose--promote pancreatic secretion of insulin
  3. tumor in region of β-cells of islets of Langerhans, associated with excessive insulin production and secretion, mostly benign solitary lesions,usually found in tail of pancreas, treatment by surgery wherever possible
  4. formed when proinsulin is converted into insulin in pancreas, essential for proper folding of insulin, has a longer t1/2 than insulin (6min)-->elevated serum levels accompanies hyperinsulinism
  5. for diagnosis of hypoglycemia
    1. adrenergic /neuroglycopenic symptoms
    2. blood glucose <50mg/dL at time of symptoms
    3. improvement of symptoms on ingestion of glucose

5 True/False questions

  1. alcohol induced hypoglycemiamay be caused by drug-induced hypoglycaemia or postprandial hypoglycaemia (within 5h of meal), some individuals manifest transitory hypoglycaemic symptoms after eating a large carbohydrate meal--causes exaggerated transient insulin response, does not usually indicate underlying disorder

          

  2. adrenergic symptoms of hypoglycemiaresult of effects of epinephrine (palpitations, tremors, sweating), usually occur following sudden drop in blood glucose levels--catecholamine surge

          

  3. high serum insulin, low C-peptide levels, low proinsulin levelsindicative of reactive hypoglycaemia, sulphonylurea overdose--promote pancreatic secretion of insulin

          

  4. high serum insulin, high C-peptide, high proinsulin levels without sulphonylureaindicative of reactive hypoglycaemia, sulphonylurea overdose--promote pancreatic secretion of insulin

          

  5. hypoglycemiausually occurs 6-7 hours after last meal, indicative of underlying disorder, most patients are Type 1 diabetics receiving too large dose of insulin, may be caused by liver disease (more than 80% of liver damage can severely compromise hepatic gluconeogenesis), can be caused by Addison's disease--hyposecretion of cortisol rendering tissues more sensitive to insulin

          

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