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5 Written Questions

5 Multiple Choice Questions

  1. condition where blood glucose level is less than 2.5mmol/L (45mg/dL), symptom of underlying disease, can develop as result of liver diease, hormonal disorder, genetic disorcer, GI tract surgery

    body responds to falling blood glucose levels by stimulating sympathteic nervous system-->induces secretino of epinephrine, cortisol, glucagon-->have collective antagonistic effect on insulin secretion

    first organ to be affected is brain

    symptoms include confusion, dizziness, shaky feelling, hunger, headaches, irritability, pounding heart, racing pulse, pale skin, sweating, trembling, weakness, anxiety

    two division of symptoms: adrenergic and neuroglycopenic

    two regulator mechanisms: pancreatic secretion of glucagon, hypothalamus glucoreceptors

    classified as either reactive hypoglycemia or true organic fasting hypoglycemia

    occurs in insulin-dependent diabetics usually as a result of excess insulin or sulphonylurea administration, strenuous exercise, insufficient carbohydrate ingestion, excess alcohol ingestion
  2. result of effects of epinephrine (palpitations, tremors, sweating), usually occur following sudden drop in blood glucose levels--catecholamine surge
  3. usually occurs 6-7 hours after last meal, indicative of underlying disorder, most patients are Type 1 diabetics receiving too large dose of insulin, may be caused by liver disease (more than 80% of liver damage can severely compromise hepatic gluconeogenesis), can be caused by Addison's disease--hyposecretion of cortisol rendering tissues more sensitive to insulin
  4. from accidental or intentional use of hypoglycaemic agents (sulphonylureas / insulin injections)

    diagnose by measuring patient's serum levels of insulin, C-peptide and proinsulin at time of showing symptoms

    show high serum insulin, low C-peptide, low proinsulin levels
  5. indicative of insulinoma

5 True/False Questions

  1. high serum insulin, low C-peptide levels, low proinsulin levelsindicative of insulin overdose, accidental or deliberate

          

  2. high serum insulin, high C-peptide, high proinsulin levels with sulphonylureaindicative of reactive hypoglycaemia, sulphonylurea overdose--promote pancreatic secretion of insulin

          

  3. fibrosarcomatumor in region of β-cells of islets of Langerhans, associated with excessive insulin production and secretion, mostly benign solitary lesions,usually found in tail of pancreas, treatment by surgery wherever possible

          

  4. glucagonomaoccur as result of tumors of α-cells of islet of Langerhans, excessive secretion of glucagon-->secondary diabetes

          

  5. insulinomatumor in region of β-cells of islets of Langerhans, associated with excessive insulin production and secretion, mostly benign solitary lesions,usually found in tail of pancreas, treatment by surgery wherever possible

          

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