| Term | Definition |
|---|
| strabismus | cross-eyes |
| leukocoria | a reflection from a white mass within the eye that gives a white pupil appearance |
| neoplasia | an abnormal cell growth which may progress to cancer |
| telomere | the end of a chromosome arm |
| centromere | attachment point on a chromosome for sister chromatids |
| Cohesin proteins | Proteins that attach the arms of the chromosome down the length of the chromosome. not the centromere |
| kinetochore | attachment point on chromosome for microtubules developed during prophase of mitosis |
| endoreplication | is the replication of DNA during S-phase but there is no followup division ie mitosis does not complete |
| polyploidy | the replicated chromosomes keep individual identity, but are 4n or more |
| polyteny | like polyploidy but chromosomes associate to make 'giant chromosomes' |
| ischemia | a lack of proper blood supply to tissue, results in damage and necrosis |
| Rb | protein that binds to transcription factors for s-phase genes and blocks them |
| p53 | a protein sensor for DNA damage that arrests cells in G1 for repair or apoptosis. it is the most commonly mutated gene in cancer |
| hereditary melanoma | a skin cancer caused by p16 mutation that accounts for 20-40% of inherited melanomas. usually sets in about 35 |
| Li-Faumeni Syndrome | rare inherited cancer caused by a mutation in p53. individuals display cancers in a variety of tissues at an early age |
Combine with other sets
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