Oncology

Created by jadel727 

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36 terms

Doxorubicin

Adriamycin

Anthracycline

Capecitabine

Xeloda

Antimetabolite

Gemcitabine

Gemzar

Antimetabolite

Paclitaxel

Taxol

Taxane

Docetaxel

Taxotere

Taxane

Topotecan

Hycamtin

Camptothecins

Irinotecan

Camptosar

Camptothecins

Oxaliplatin

Eloxatin

Platinum Compound

Bicalutamide

Casodex

Antiandrogen

Anastrozole

Arimidex

Aromatase Inhibitor

Letrozole

Femara

Aromatase Inhibitor

Erlotinib

Tarceva

EGFR-tyrosine kinase inhibitor

Imatinib

Gleevec

Tyrosine kinase inhibitor

Trastuzumab

Herceptin

Monoclonal Antibody

Bevacizumab

Avastin

Monoclonal Antibody

Rituximab

Rituxan

Monoclonal Antibody

Vinorelbine

Navelbine

Vinca Alkaloid

Leuprolide

Lupron

LHRH agonist

Goserelin

Zoladex

LHRH agonist

Alkylating Agent

Non-Specific

Alkylation of DNA

Antitumor Abx (Anthracycline)

Non-Specific

Binds to DNA, Inhibits RNA synthesis

Antimetabolites

S-Phase

Similar to normal cell substances & when incorporated in cell, makes cell unable to divide

Camptothecins

S-Phase

Topoisomerase I inhibitor (causing DNA breakage)

Epipodophyhllotoxins

G2 & S-Phase

Topoisomerase II inhibitor (causing DNA breakage)

Taxanes

G2 & M Phase

Antimicrotubular agent, inhibits mitosis by interfering with the microtubules, which help move chromosomes during mitosis

Vinca alkaloids

G2 & M phase

Antimicrotubular agent as above

Antiestrogens

Bind to estrogen receptors on tumor surface to prevent cell growth/cause cell death

Aromatase Inhibitors

Block aromatase enzyme, which converts androgens to estrogen causing tumors to shrink

Antiandrogens

Inhibit the binding of testosterone to the androgen receptors in the prostate

LHRH agonists

Signals pituitary to stop releasing LH, which has a direct effect on testicles & ovaries

Monoclonal Antibodies

Target specific antigens on cancer cell surface. Marks cell for attack by immune system. Blocks specific receptors. Some deliver antitumor agent to a target.

Serotonin Agonists

* Selective blockade of serotonin 5-HT3 receptors in GI tract & brain.
* HA, Diarrhea, Constipation, $$$
* Ondansetron, Granisetron, Dolasetron, Palonosetron

Phenothiazines

* Blockade of dopamine receptors in chemoreceptor trigger zone.
* Sedation, Hypotension, EPS
* Prochlorperazine, Promethazine, Triethylperazine, Trimethobenzamide

Corticosteroids

* Unknown MOA
* Insomnia, hyperglycemia, inc appetite, euphoria, aggitation/anxiety
* Dexamethasone, Methylprednisolone

Cannabinoids

* Unknown MOA
* Improves nausea, appetite, pain
Dronabinol (marinol)

Benzodiazepines

* Amnestic, anxiolytic, sedative, Great for anticipatory vomiting
* Sedation, hypotension, disinhibition, motor incoordination
* Lorazepam

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