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General Info Theophylline

relaxes bronchial and pulmonary blood vessel smooth muscles
central respiratory stimulant
may increase collateral ventilation, respiratory muscle function, mucocilliary clearance and central respiratory drive
improves arterial partial pressures of O2
reduction of pulmonary vascular resistance

Side effects

nausea
vomitting
tachycardia
hyperglycemia
seizures
insomnia

Therapeutic level

8-12 mcg/mL

Drug intx (increase metabolism)

cigarette smoking
high protein diet
hyperthyroidism
marijuana smoking
carbamazepine
rifampin
phenytoin

Drug intx (decrease metabolism)

age >60
severe hypoxemia
CHF
Viral infx
allopurinol, cimetidine
erythromycin, quinolone, verapamil

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