non-selective COX inhibitors

70 terms by rach33ael 

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meloxicam

10 fold COX-2 over COX-1 inhibition, no platelet effect, less GI toxicity

diclofenac

graetest alteration in hepatic aminotransferase, combination drug w/ misoprostol and with omeprazole, rectal and eye preparations, no to children and pregnant women

diclofenac (and meclofenamate, mefanamic acid)

no to children and pregnant women

diclofenac

greatest alteration in hepatic aminotransferase

diclofenac

combination drug w/ misoprostol and with omeprazole

misoprostol (arthrotec) (PGE1--decreases GI toxicity), omeprazole (decreases GI toxicity)

diclofenac can be a combination drug with __ and __

diclofenac

rectal and eye preparations

etodolac

COX-2 inhibition relative to COX-1 is 10/1, less GI toxicity, impairment of renal function

COX2, COX1, 10/1, GI, renal

etodolac: __ inhibiton relative to __ is __; less __ toxicity, impairment of __ function

hepatic aminotransferase, children, prengnant women

diclofenac: greatest alteration in __ __; no to __

10 fold, 2, 1, no platelet, GI

meloxicam: __ __ COX__ over COX__ inhibiton, __ _ effects, less __ toxicity

flurbiprofen

alters TNF-alpha and nitric oxide synthesis, topical in eye and IV, toxicity includes rigidity, ataxia and tremor

TNF-alpha, nitric oxide synthesis, topical, IV, rigidity, ataxia, tremor

flurbiprofen alters __ and __; __ in eye and __, toxicity includeds: __, __ and __

flurbiprofen

toxicity includes rigidity, ataxia, and tremor

ibuprofen

analgesic at low doses, high doses anti-inflammatory, cream and liquid gel, less GI toxicity than aspirin, interaction w/ aspirin in anti-inflammatory and anti-platelet effects, platelet effect, aplastic anemia

Ibuprofen

has platelet effects ! (besides Aspirin)

analgesic, antiinflammatory, GI, aspirin, anti-inflammatory, anti-platelet, platelet, aplastic anemia

ibuprofen: __ at low doses, high doses ___, cream and liquid gel, less __ toxicity than aspirin, interaction with __ in __ and __effects, __ effect, __ __

ibuprofen

interaction with aspirin in antiinflammatory and antiplatelet effects

less anti-inflammatory

IBU + aspirin= ___ effect

decreased aspirin, platelets

IBU + aspirin= ___ effect on __

ibuprofen

side effect: aplastic anemia

flurbiprofen

not just because its a COX inhibitor it works, but also because TNF-alpha and Nitric oxide synthesis occurs

indomethacin

may decrease phopholipase A and C, decrease neutrophil migration and lymphocyte proliferation, more potent than salicylates in inflammation, some platelet effect, eye preparation, toxicity is high, GI, headache (30%) thrombocytopenia and hyperkalemia (renal toxicity)

indomethacin

may decrease phospholipase A and C

indomethacin

decreases neutrophil migration and lymphocyte proliferation

indomethacin

more potent than salicylates in inflammation

indomethacin

toxicity is high: GI, headache, thrombocytopenia, hyperkalemia

indomethacin

thrombocytopenia

indomethacin

hyperkalemia (renal toxicity)

phospholipase A and C, neutrophil, lymphocyte, potent, inflammation, platelet, eye, GI, headache, thrombocytophenia, hyperkalemia, renal

indomethacin: may decrease __, decrease __ migration and __ proliferation, more __ than salicylates in __, some __ effect, __ preparation, toxicity is high: __, __ (30%) __ and ___ (__ toxicity)

ketoprofen

inhibits both cyclooxygenase and lipooxygenase, stabilizes lysosomes, less GI toxicity than aspirin

cylcooxygenase and lipooxygenase

ketoprofen inhibits:

cyclooxygenase, lipooxygenase, lysosomes, GI

ketoprofen inhibits __ and __; stabilizes __, less __ toxicity than aspirin

ketorolac

potent analgesic, moderate anti-inflammatory, IM, IV used with opiods, eye

potent analgesic, anti-inflammatory, opiods

ketoralac: __ __, moderate __, IM, IV used with __, eye

ketoralac

potent analgesic

ketoralac

used w/ opiods

ketoralac

moderate anti-inflammatory

nabumetone, sulindac

prodrug

nabumetone

prodrug, only non-acid NSAID, half life is 24 hours, less GI toxicity than aspirin, photosensitivity, and pseudoprophyria

nabumetone

side effect: photosensitivity, pseudoprophyria

nabumetone

side effect: photosensitivity

nabumetone

side effect: pseudoprophyria

nabumetone

only non-acid NSAID

nabumetone

half life 24 hours

prodrug

nabumetone is a __

naproxen

20X more potent in COX inhibition than aspirin, long half-life, slow release available, topical and eye, greater GI bleeding than ibuprofen

naproxen

20 X more potent in COX inhibition than aspirin

naproxen

long half life, slow release available

naproxen

greater GI bleeding than ibuprofen

20X, COX inhibition, long, greater GI, ibuprofen

naproxen: __ more potent in __ __ than aspirin, __ half-life, slow release available, topical and eye, __ __ bleeding than ___

naproxen

NSAID with lowest risk of cardiovascular disease (other than aspirin)

cardiovascular disease

naproxen is the NSAID with the lowest risk of ___

oxaprozin

long half-life, uricosuric

oxaprozin

uricosuric (gout)

piroxicam

analgesic, antipyretic, and anti-inflammatory (alters leukocyte migration, etc), long half life, highest GI toxicity at high doses

piroxicam

alters leukocyte migration, etc

piroxicam

inhibits everything

piroxicam

highest GI toxicity at high doses

analgesic, antipyretic, antiinflammatory, long, highest GI

piroxicam: __, __, and __ (alters __ migration), __ halflife, __ __ toxicity at high doses

sulindac

prodrug, metabolized to sulfide (active metabolite), reduction mediated by gut bacteria, high concentrations in colon (colorectal cance), less sulfide in upper GI and in kidney (less toxic), high liver toxicity

sulindac

metabolized to active form sulfide

prodrug, sulfide, gut, colon, colorectal, sulfide, upper GI, kidney, liver

sulindac: __, metabolized to __ (active metabolite), reduction mediated by __ bacteria, high concentration in __ (__ cancer), less __ in __ and in __ (less toxic), HIGH __ toxicity

sulindac

HIGH LIVER TOXICITY

sulindac

prevents 2 organs from damage (GI and kidney), but very bad for liver

sulindac

sulfoxide form; reduced form is active (inhibits COX)

tolmetin

less GI toxicity than aspirin

oxaprozin

half-life of 50 hours

ketoralac

post surgey, decreases amount of opiods you need

indomethacin

more potent than aspirin as antiinflammatory

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