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stem cell growth factors

scf (c-kit ligand), flt3-ligand

granulocyte growth factor

gm-csf

eosinophil growth factor

il-5

monocyte growth factor

m-csf

rbc growth factor

epo

megakaryocyte/platelet growth factor

thrombopoietin

b cell growth factor

flt3-ligand

t cell growth factor

il-7

nk growth factor

il-15

heinz bodies

denatured hemoglobin

macrocytic target cells

liver disease

microcytic target cells

thalassemia

irregular spikes on rbc

acanthocytes

burr cell rbc

echinocyte

Cells in B12/folate deficiency

hypersegmented neutros

Major problem in B12 deficiency

neurological

Most common cause of pernicious anemia

antibodies to parietal cells

Anemia with atrophic glossitis and SACD

pernicious

Place of absorption for B12

terminal ileum

place of absorption for folate

jejunum

place of iron uptake

duodenum

iron deficiency is ___, including cancer, until proven otherwise

gi blood lose

microcytic hypochromic anemia, atrophic glossitis, esophageal webs

plummer-vinson syndrome

koilonychia (spoon nails)

anemia

key lab finding in Fe deficient anemia

increased tibc

mechanism for beta thalassemia

gene mutation

mechanism for alpha thalassemia

gene deletion

marker in beta thalassemia major

increased hbf

marker in beta thalassemia minor

increased hba2

form of alpha thalassemia that is most likely to be passed on is most prevalent in...

asia

Lose of 3 genes in alpha thalassemia

HbH disease

Loss of 4 genes in alpha thalassemia

Hb barts

type of cells seen in thalassemia

microcytic target cells

inherited aplastic anemia

fanconi anemia

TAR babies

fanconi anemia

hereditary pattern of hereditary spherocytosis

autosomal dominant

two possible deficiencies in hereditary spherocytosis

ankyrin, spectrin

PNH gene defect

piga

gene production deficient in pnh

gpi

Triad for pnh

hemolysis, pancytopenia, thrombosis

inheritance in g6pd

x-linked

cells in g6pd defect

bite cells, heinz bodies

defect in sickle cell anemia

beta chain, 6, glutamate replaced by valine

defect in SC disease

beta chain, 6, glutamate replaced by lysine

hemoglobin that is protective in sickle cell

hbf

dactylitis

sickle cell in kids

cells in warm autoimmune hemolytic anemia

spherocytes, reticulocytosis

most common Ig in warm autoimmune hemolytic ame,oa

IgG kappa

most common Ig in cold agglutinins

Igm

antigen in mycoplasma pneumonia cold agglutinins

anti-I

antigen in ebv cold agglutinins

anti-i

antigen in cold hemoysins

anti-p

microangiopathic hemolytic anemias

dic, hus, ttp

hus triad

schistocytes, thrombocytopenia, renal failure

ttp pentad

schistocytes, thrombocytopenia, renal failure, neuro signs, fever

most common cause of ttp

antibodies to vwf

increased protein in porphyria with neuro symptoms

amlev

screening for acute attacks of porphyria

urine pbg

most common porphyria

porphyria cutanea tarda

mutation in polycythemia rubra vera

jak2

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