Biology 08 - Respiration

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Created by:

pho3nix  on January 6, 2011

Subjects:

mcat, biology, respiration

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Biology 08 - Respiration

Respiration
- a broad term referring to:
a) the exchange of gases between an organism and its external environment
b) the transport of these gases within the organism
c) the diffusion of gases into and out of cells
- aerobic organisms exchange CO₂ generated during cellular respiration for O₂ obtained from the external environment
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Terms

Definitions

Respiration- a broad term referring to:
a) the exchange of gases between an organism and its external environment
b) the transport of these gases within the organism
c) the diffusion of gases into and out of cells
- aerobic organisms exchange CO₂ generated during cellular respiration for O₂ obtained from the external environment
Lungs - higher vertebrates' respiratory system where gas exchange occurs at a single respiratory surface
Respiratory Airways - air enters through external nares (nostrils)
- nasal cavities, filtered by mucous and nasal hairs
- pharynx
- larynx (epiglottis closes the larynx when swallowing food)
- trachea
- two bronchi
- bronchioles
- alveoli
Bronchi & Trachea - lined by ciliated epithelial cells
- filters and traps particles inhaled along with air
Alveoli- clusters of small air sacs
- gas exchange between the lungs and circulatory system occurs here
- each alveolus is coated with a thin layer of liquid containing surfactant and is surrounded by an extensive network of capillaries
- three hundred million alveoli provide approximately 100 m² of moist respiratory surface for gas exchange
Surfactant - lowers the surface tension of the alveoli
- facilitates gas exchange across the membranes
- reduces high surface tension of the fluid lining the alveoli, preventing alveolar collapse during exhalation
Ventilation of the Lungs - "breathing"
- the process by which air is inhaled and exhaled
- the purpose is to take in oxygen from the atmosphere and eliminate carbon dioxide from the body
- ventilating mechanism is dependent upon pressure changes in the thoracic cavity
Thoracic Cavity - the body cavity that contains the heart and lungs
Diaphragm - a muscle that separates the thoracic cavity from the abdominal cavity
Lungs' Membranes - surrounded by visceral pleura and parietal pleura
Interpleural space - space between two membranes
- contains a thin layer of fluid
- the pressure differential between the intrapleural space and the lungs (which is essentially atmospheric pressure) prevents lungs from collapsing
Pneumothorax - caused by penetrating injury trauma to the chest
- air enters the intrapleural space
- intrapleural pressure increases
- lung collapses
- treated by inserting a needle and withdrawing air from the intrapleural space
Stages of Ventilation:
Inhalation
- diaphragm contracts and flattens
- external intercostal muscles contract
- rib cage and chest wall pushed up and out
- causes the thoracic cavity to increase in volume
- intrapleural pressure decreases
- lungs expand and fill with air
Negative-Pressure Breathing - during inhalation, air is drawn in by a vacuum
Stages of Ventilation:
Exhalation
- is generally a passive process
- the lungs and chest wall are highly elastic and tend to recoil to their original positions after inhalation
- diaphragm and external intercostal muscles relax
- chest wall pushes inward
- decrease in thoracic cavity volume casues air pressure in the intrapleural space to increase
- lungs deflate, air forced out of the alveoli
- internal intercostal muscles contract & pull the rib cage down
Control of Ventilation:
Medulla Oblongata
- ventilation is regulated by neurons in medulla oblongata, whose rhythmic discharges stimulate the intercostal muscles and/or the diaphragm to contract
- neural signals can be modified by chemoreceptors, which respond to changes in the pH and the partial pressure of CO2 in the blood
- when CO₂'s partial pressure increases, the medulla oblogata stimulates an increase in the rate of ventilation
Control of Ventilation:
Cerebrum
- ventilation can be consciously controlled by the cerebrum
- if a person tries to hold his breath too long, CO₂ concentration in blood incresaes, medulla oblongata override this attempt and stimulate inhalation
Hyperventilation - deep, rapid breathing
- lowers the partial pressure of CO₂ in the blood below normal
- chemoreceptors sense this and send signals to the respiratory center, which temporarily inhibits breathing
Spirometer - an instrument to measure the amount of air normally present in the respiratory system and the rate of which ventilation occurs
Vital Capacity - the maximum amount of air that can be forcibly inhaled and exhaled from the lungs
Tidal Volume - the amount of air normally inhaled and exhaled which each breath
Residual Volume - the air that always remains in the lungs
- prevents alveoli from collapsing
Expiratory Reserve Volume - the volume of air that can still be forcibly exhaled following a normal exhalation
Total Lung Capacity - vital capacity + residual volume
Gas Exchange- occurs by diffusion across the pulmonary capillary walls and the alveoli
- gases move from regions of higher partial pressure to areas with lower partial pressure
- deoxygenated blood enters pulmonary capillaries (has lower partial pressure of O₂ than the air in the alveoli
- thus O₂ diffuses down its gradient into the capillaries where it binds with hemoglobin
- returns to the heart via the pulmonary veins
Gas Exchange continued - partial pressure of CO₂ in the capillaries is greater than of the inhaled alveolar air
- thus CO₂ diffuses from the capillaries into the alveoli, where it is released into the external environment during exhalation
Pulmonary Capillaries - a dense network of minute blood vessels surrounding the alveoli
At High Altitudes- partial pressure of O₂ in the atmosphere declines
- harder to get enough oxygen to diffuse into the capillaries
- the body can compensate by hyperventilation and by polycythemia
- the affinity of hemoglobin for oxygen decreases to facilitate unloading of oxygen in tissues
- there is greater vascularization of the peripheral tissues
Polycythemia - increasing the production of red blood cells to carry more oxygen

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