Pharmacology Test 4

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104 terms

adrenergic agonists

drugs that stimulate and mimic the actions of the sympathetic nervous system

sympathomimetics

adrenergic agonists

adrenergic receptors

receptor sites for the sympathetic neurotransmitters norepinephrine and epinephrine

alpha-adrenergic receptors

a class of adrenergic receptors that are further subdivided into alpha 1 and alpha 2 and are differentiated by anatomic location

autonomic functions

bodily functions that are involuntary and result from the physiologic activity of the ANS, functions often occur in pairs of opposing actions

autonomic nervous system

a branch of the peripheral nervous system that controls autonomic bodily functions

sympathetic and parasympathetic nervous system

make up the autonomic nervous system

beta adrenergic receptors

receptors located in postsynaptic effector cells of tissues

beta 1 adrenergic receptors

located primarily in the heart

beta 2 adrenergic receptors

located primarily in the smooth muscle fibers of bronchioles and viseral organs

catecholamines

substances that can produce sympathomimetic response

endogenous catecholimines

epinephrine, norepinephrine and dopamine

synthetic catecholamine drug

dobutamine

dopaminergic receptor

a third type of adrenergic receptor in addition to alpha and beta and activated by binding of neurotransmitter dopamine

mydriasis

pupillary dilation

ophthalmics

drugs for the eye

positive chronotropic effect

increase in heart rate

positive dromotropic effect

an increase in the conduction of cardiac electrical impulses through the AV node

ventricular contractions

systolic heartbeat

positive inotropic effect

increase in the force of contraction of the heart muscle

drugs used to mimic catecholamines-epinephrine, norepinephrine and dopamine

sympathomimetics

synaptic cleft

space between adjacent nerve cells or the nerve cell membrane and an effector organ cell membrane

nervous system

consists of central and peripheral

central nervous system

brain and spinal cord

peripheral nervous system

autonomic and somatic nervous systems

somatic nervous system

skeletal muscle

parasympathetic and sympathetic nervous system

autonomic nervous system

parasympathetic nervous system

cholinergic-acetylcholine

sympathetic nervous system

adrenergic-norepinephrine

synapse

synaptic cleft

fight or flight

sympathetic branch of the autonomic nervous system

vasoactive adrenergics

adrenergics having primarily cardiovascular effects

dobutamine

dobutrex-beta 1 selective vasoactive adrenergic

dopamine

intropin-naturally occuring catecholimine neurotransmitter in SNS

epinephrine

adrenalin-endogenous vasoactive catecholamine

midodrine

requires careful blood pressure monitoring

increased cardiac contractility

beta 1 agonists can cause......

inhaled salmeterol

is for the prevention of bronchospasm

negative chronotropic effect

decreased heart rate

beta adrenergic agonist side effects include...

mild tremors, tachycardia,palpitations,nervousness

agonists

drugs with specific receptor affinity that mimic the bodys natural chemicals

angina

paroxysmal chest pain caused by myocardial ischemia

paroxysmal

sudden

antagonists

drugs that bind to specific receptors and inhibit or block the response of the receptors

dysrhythmias

irregular heart rythms

arrhythmias

dysrhythmias

extravasation

leaky blood vessels

lipophilicity

the chemical attraction of a substance to lipid molecules

pheochromocytoma

vascular adrenal gland tumor secretes epinephrine and norepinephrine

sympatholytics

drugs that inhibit the postganlionic functioning of the sympathetic nervous system

tamsulosin

flomax

vasodilation

result of injecting alpha blocker phentolamine

phentolamine

regitine-alpha blocker

bradycardia

beta 1 blockers can cause

main purpose of beta blockers

protect the heart from circulating catecholamines

alpha-blockers can cause....

orthostatic hypotension,increased urine flow,headaches

acetylcholine-needed for normal brain function

neurotransmitter responsible for transmission of nerve impulses to effector cells in the PNS

acetylcholinesterase

enzyme responsible for the breakdown of acetylcholine

cholinesterase

acetylcholinesterase

cholingergic receptor

nerve receptors that is stimulated by acetylcholine

miosis

pupil contraction

muscarinic receptors

cholinergic receptors that are located postsynaptically in the effector organs such as smooth muscle

nicotinic receptors

cholinergic receptors located in the ganglia of both PNS and SNS

stimulated by alkaloid nicotine

nicotinic receptors

ganglia

where presynaptic and postsynaptic nerve fibers meet

parasympathomimetics

drugs that mimic the PNS

cholinergic agonist drugs

parasympathomimetics

bethanechol

urecholine-direct acting cholinergic agonist should be taken with meals to avoid GI upset, contraindicated with peptic ulcer

donepezil

aricept-indirect acting anticholinesterase drug

atropine

treat cholinergic drug overdose

pyridostigmine

mestinon-treat MG, should be taken 30 minutes before meals

cholinergic crisis symptoms include

hypotension,syncope,dyspnea

cholinergic-blocking drugs

block the action of acetylcholine at receptor sites-

mydriasis

dilation of the pupil

parasympatholytics

reduce the activity of the PNS

anticholinergics-avoid high temperatures

parasympatholytics-can cause dry mouth

antimuscarinic drugs

anticholinergics or parasympatholytics-avoid using with TCA

primarily used in the management of cardiovascular disorders

atropine

tolterodine

detrol-muscarinic receptor blocker

cholinergic antagonists

parasympatholytics,cholinergic blockers, anticholinergics-contraindicated with BPH

vasoconstriction and central nervous system stimulation

predominant alpha adrenergic agonist response

stimulation of beta 1 in the kidneys

increases renin production

beta 2 agonists

helpful in the treatment of asthma and bronchitis

beta 2 selective adrenergic drugs include

albuterol, ephedrine, formoterol,levalbuterol,metaproterenol, pirbuterol, salmeterol and terbutaline

esmolol

rapid acting sympatholytic drug to lower blood pressure

alpha adrenergic receptor stimulation results in

vasoconstriction of blood vessels

beta 1 adrenergic receptors results in

bronchodilation

phentolamine-alpha blocker

used to treat infiltration of adrenergic drugs by causing localized vasodilation

adventitious

abnormal

alpha 2 active drug

clonidine

benign prostatic hyperplasia

bph-treated with terozosin and doxazosin, alpha blockers

tamsulosin

flomax, to treat bph

glycogenolysis

production of glucose from glycogen in the liver

angina

chest pain

atropine-antimuscarinic

management of bradycardia for overdose of beta blockers

atenolol

tenormin-beta blocker to prevent future MI

nonselective beta blockers

protect the heart from circulating catecholamines

physostigmine

antidote for anticholinergic poisoning, treatment for MG

bethanechol

used to treat decreased or absent peristalsis related to surgery

dicyclomine

bentyl-gi motility-anticholinergic

glycopyrrolate

robinal-antimuscarinic-decrease secretions

oxybutynin

ditropan-overactive bladder-antimuscarinic

scopolamine

anticholinergic-motion sickness

contraindications for anticholinergic

bph,tricyclic antidepressants

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