The following sequence is characterized by what type of necrosis?
Anoxia --> Mitochondrial Pump problems and broken membranes --> Ca2+ influx --> __________ ---> _________.
Cells coagulate (pink appearance in center) --> Neutrophils clean up.
What type of necrosis is characterized by an abscess cavity that gets infected and fills with liquid (usually from bacterial or fungal infection)?
Area of destroyed tissue becomes filled with pus liquefies. Commonly seen in CNS cell hypoxic death.
What type of necrosis is classic for TB or certain bacterial infections, can occur in bone, and spurs on a giant cell reaction where macrophages combine to form "giant cells." It is not completely liquid or solid, but acellular dead material. Center is dead tissue and organisms, but outer edges have granulomatous reaction.
In what type of necrosis does saponification occur? What is saponficiation?
Fat is digested and turned into soap by the reaction of metal with a fatty acid (i.e. fatty acid + metal -- > soap)
This occurs in Fat Necrosis.
What type of necrosis is acute pancreatitis a classic example?
Pancreas releases its esterases and lipases, will saponfiy the nearby fat (fat is digested).
Over secretion of renin by the small kidney would cause what to occur?
Renin is a hormone that increases blood pressure, so over secretion of renin leads to increased blood flow, blood pressure.
What term is used to describe a shrinkage in cell size through loss of cell structures; shrinakge in size of an organ; a decrease in number of cells, cells are replaced by connective and adipose tissue ?
What term is used to describe an increase in the size of cell due to an increase in cell structures. These cells do not enter mitotic state,n quiescent (in G₀ cycle phase).
What term is used to describe an increase in the number of cells. Continously dividing cells (in the mitotic cell cycle).
What is an example of a physiologic cause of hyperplasia? Pathologic?
Physiologic cause - hormonal (breast at different phases of menstrual cycle, during pregnancy, and when lactating; pt uterus; prostate gland).
Pathologic- excessive stimulation of target cells (endometerial hyperplasia); ALSO, toxin (cigarettes); drug(lymphoid hyperplasia).
Pregnant uterus that undergoes changes endometrium that are __________ and changes int he myomemtrium that are more ___________.
What is a reversible change in one adult cell type that is replaced by another adult cell type?
What is disordered growth known as?
What is lack of differentiation known as?
What is new growth known as?
The following list represents what general concept?
1.) Degenerations (reversible)
3.) Adaptation (cellular) - atrophy, hypertrtophy, hyperplasia, metaplasia, dysplasia
4.) Inflitrations (tissue)- fatty; amyloid; iron; hyalin; Changes withing the cell in tissue o normal or abnormal components being stored in the cell.
How cells react to injury