| Term | Definition |
|---|
| Phosphatidate | Phosphoglycerate with 2 fatty acids and a phosphate group |
| Dipalmitoyl-phophatidylcholine | this phospholipid is a major component of lung surfactant |
| perfluorcarbon | synthetic lung surfactant used in partial liquid ventilation |
| Phosphatidylinositol | this phospholipid is cleaved into DAG and IP3 in signaling cascades, cut by phospholipase C |
| lysophosphatidate | phosphoglycerate with a single fatty acid chain (other two groups are alcohol and phosphate) |
| CDP | cytidine diphosphate |
| Glyceryl Ether phospholipids | synthesis of this phospholipid starts with dihydroxyacetone phosphate instead of glycerol-3-phosphate |
| Sphingosine | This alternate fatty acid backbone is derived from palmitoyl-CoA and serine |
| Ceramide | N-acyl-sphingosine (no sugar or phosphate group) |
| Sphingomyelin | the only phosphorylated sphingolipid |
| phosphorylcholine | the phospho-group added to ceramide to made sphingomyelin (added from phophatidylcholine) |
| Cerebroside | sphingolipid made from ceramide with glucose or galactose added. |
| Ganglioside | made by adding oligosaccharide with sialic acid to cerebroside |
| Globoside | made by adding oligosaccharide without sialic acid to cerebroside |
| Tay-Sachs Disease | Disease resulting from autosomal recessive gene defect for hexoaminidase A. Can't break down GalNAc. Results in neurological deterioration |
| Gaucher's Disease | Disease is missing glucocerebrocidase (beta-glucosidase). Type 1 is most common, Type 2 is most severe. Multiple system involvement including anemia, liver enlargement, skeletal weakness |
| Niemann-Pick Disease (Type A) | Disease due to deficiency of sphingomyelinase. Autosomal recessive, death by age 3 |
| Sphingomyelinase | Enzymes that cuts off the phosphocholine off sphingomyelin |
| Prostaglandin Synthase | This enzyme has two subunits, cycloxygenase and hydroperoxidase |
| Prostacyclins | Made from prostaglandin H2, up regulate vasodilation and anti-platelet aggregation |
| Thromboxanes | Made from prostaglandin H2, up regulate vasoconstriction, blood coagulation and platelet aggrecation |
| Leukotrienes | Made from arachidonate, mediate asthma constriction |
Combine with other sets
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