Receptor Tyrosine Kinases flash cards

Set: Receptor Tyrosine Kinases

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Term	Definition
Class I	ligand binding induces monomer dimerization; autophosphorylation of cytoplasmic domain
Class II	ligand binding induces active conformation of disulfide crosslinked dimer; autphosphorylation of cytoplasmic domain and IRS
Class III	dimer ligand crosslinks monomers; autophosphorylation of cytoplasmic domain
SH2	bind to peptide motifs with phospho-tyrosine
PTB	bind to peptide motifs with phopho-tyrosine or tyrosine
SH3	bind to proline rich motifs
PH	bind to membranes or membrane proteins