MEDEX - Pharmaco-

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164 terms · MEDEX - Pharmaco-

cimetidine

Histamine H2 receptor antagonists (3)

famotidine

Histamine H2 receptor antagonists (3)

ranitidine

Histamine H2 receptor antagonists (3)

HCl (reduces heartburn)

Cimetidine, Famotidine, Ranitidine reduce the amount of ______ secretion

Gastrin

3 pathways that stimulate gastric acid secretion at parietal cell = ___.

ACH

3 pathways that stimulate gastric acid secretion at parietal cell = ___.

histamine

3 pathways that stimulate gastric acid secretion at parietal cell = ___.

Gynecomastia (man-rack)

Cimetidine = this negative side effect in men ______.

Cimetidine

Cytochrome P450 does not interact well with ___ Rx.

PPI's (Omeprazole)

Gastric Acid secretion is prevented by taking ___.

PPI's, Omeprazole

______ are more effective than H2 blockers. i.e. _____.

Zollinger-Ellison

PPI's (Omeprazole)are indicated in people with ___ syndrome.

Peptic ulcer

PPI's (Omeprazole)are indicated in people with GERD or ___ ___ disease.

dyspepsia

PPI's (Omeprazole)are indicated in people with ___ Sx's.

No, well tolerated

Are there many adverse effects with PPI's?

Stomach Acid; Pain or dyspepsia

Gastric Antacids (Calcium Carbonate) neutralizes_______ and relieves _______

Calcium Carbonate (Gastric Antacids)

Acid Indigestion and moderate dyspepsia are best relieved with ____.

Antacids ie. Calcium Carbonate

Constipation, diarrhea, & rebound acid = adverse effects of ___ class GI drugs.

Sucralfate

Muco-protective drug that adheres to ulcer craters = ___.

Sucralfate

_______ Rx's form a protective barrier to acid and pepsin for healing.

Ulcers

Sucralfate can treat and prevent active ________

Sucralfate

People who cannot tolerate PPI's or H2 blockers can take

impairs

Sucralfate ________ absorption of some drugs (flouro's, digoxin, ketoconazole)

Misoprostol

Muco-protective drug that promotes secretion of mucous and bicarb = ___.

Gastric , Duodenal

Long term NSAID patient takes Misoprostol to prevent _____ and ______ ulcers

kinetic

Metoclopramide is a pro_______ drug

Metoclopramide

Propulsivity of the GI tract is enhanced with ___________, a prokinetic drug.

CNS

Metoclopramide negative side effects include ___ involvement & pseudoparkinsonism

Psyllium (Metamucil)

Chronic constipation is relieved by________, a bulk-forming laxative

water

Psyllium retains _______ , which increases distention of intestinal wall

Peristalsis

Mechanical distention of intestinal wall from Psyllium promotes________.

Psyllium (Metamucil)

Safest and most physiologic type of laxative = ___.

Docusate Sodium

A hard and dry stool is softened by using ____ Rx.

Stool Softener

Docusate Sodium is considered a ___ ____, which is used for constipation.

osmotic

Milk of magnesia (MOM) is an ___ laxative.

poisoned, OD

Milk of magnesia is used in patients who are ______ or ___ on drugs before surgery

Renal

Milk of magnesia is contraincated in ___ patients.

dehydration

Concern for prolonged milk of magnesia use = ___ and electrolyte imbalance.

Stimulant

Senna is a natural ________ laxative

Senna

___ is anatural substance stimulates parastolysis.

Senna

Surgery or exam of the bowels can be done after the patient takes...

abdominal, depletion

Senna can cause _______ cramping and fluid ________

Shart

Diarrhea combined with a fart is called ___.

Diarrhea

Diphenoxylate and Loperamide treat ___.

Diphenoxylate

To prevent peristalsis thus controlling diarrhea you would take (2) ___.

Loperamide

To prevent peristalsis thus controlling diarrhea you would take (2) ___.

Opioids

Diphenoxylate and Loperamide are __ class Rx's.

traveler's (infectious)

Bismuth Subsalicylate treats ________ diarrhea

Taco (it's toxic in large amounts)

An antisecretory agent like bismuth subsalicylate is "____"genic :)

Pepto Bismol

Bismuth Subsalicylate is also called ___.

Constipation

Excessive use of Diphenoxylate or Loperamide would cause ___.

Ondansetron "On Dance A Tron"

At the Serotonin 5-HT3 "dance club" you can control your chemo N&V with

Nausea, vomiting

Prochlorperazine relieves severe______ and ____ Sx's.

Post-op

Metoclopramide is indicated in patients with____ N&V or chemo.

Dronabinol

If no other N&V medication is working, try using a marijuana derivative called...

Appetite

Dronabinol prevents N&V in chemo and HIV pts and also stimulates your ________.

Vertigo or motion sickness

Promethazine is a antihistamine that prevents N&V in those dizzy patients with ___.

Motion

Scopolamine is a prophylaxis for _____ sickness.

Pharmacokenetics

___is concerned with the metabolism & concentration of a drug.

Pharmacodynamics

___ is the effect of a drug on the body

Slow

Tablets are ___ in availability compared to IV Rx's.

Varies

Gastric emptying ___ from person to person.

Measuring

Disadvantages of liquid meds is the need for a ___ device.

Less

Liqiuds are ___ stable than pills.

Exact

Liquids can be made to the ___ concentration needed

Slow

Skin patches = ___ medication release

Steady

May not be a ___ dose of meds over life-span of patch

Absorbed

Patch medication penitrates the skin & is ___ into the blood

Oral/nasal

Aresol = __ route of administration (2)

Quickly

Aresol medication is ___ absorbed.

Dose

Actual ___ can vary w/ areosol Rx's.

Topical

Base dissolves as medication is absorbed in ___ route Rx's.

Penitrate

Water soluble topicals do not ___ the skin well

Suppositories

___ are a good route for vomiting patients

GI

Entrel adminstration of a drug = ___ absorption

Needle

Parental Rx adminstration requires a ___ .

PO

Three enteral routes include (3) ___.

Sublingual

Three enteral routes include (3) ___,

Rectal

Three enteral routes include (3) ___,

Buccal

Similar to sublingual, ___ administration is also in the mouth.

Nitroglycerin

Example of sublingual medication =___.

Small

Sublingual doses have to be ___ compared to PO doses

Inactivate

Gastric acid can ___ some oral meds = disadvantages

Portal

Rectal absorption by passes hepatic __- system.

Immediately

IV drug effects are available ___.

Delayed

Effects of PO drugs are ___.

Controlled

IV doses can be precisely ___.

Quickly

Water based IM injections are absorbed ___ compared to hydrophobic Rx's.

Slower

Lipid based IM injection are absorbed ___ than water-based.

Slower/Later

IM meds are available ___ than IV meds.

Painful

IM injection sites can be ___ for days.

Slower

Sub-Q inj are absorbed ___ than IM

Small

Sub-Q inj can only be in ___ volumes

IV

___ route has 100% bioavailability.

Subarachnoid

Iintrathecal route is directly in the ___ space.

Intrathecal

When med cannot penetrate BBB in menigitis, use ___ route.

Nose

An insufflational med is used in the ___.

Allergy

Intradermal route is used in ___ testing.

Arthritic

Intrarticular drugs are used for ___ conditions.

Days

Advantages of fentanyl transdermal is it releases medication over ___.

Fast

Effects of inhaled meds are ___ to hit the body.

Local/confirmed

Effects of topical meds are usually ___ to that region.

Mucus

Topicals can be used on both skin & ___ membranes

Chemical

Generic names of meds are often the ___ name.

Absorption

Rate of ___ effects how fast a medication is available.

Distributed

How a drug is ___ throughout the body determines availability.

Water

___ soluble meds are distributed faster than lipid soluable meds.

Quickly/long

How ___ a medication is metabolized dermines how long its available

Longer

Meds that are excreted slowly are available ___ then fast ones.

Slower

Large molecules are distributed in body ___ than small ones.

Longer

Lipid soluable drugs are available for distribution ___ than H20 Soluable ones.

Distribution

Protein binding & unbinding effects the ___ of a medication.

Blood

Some organs have more ___ flow than others.

First Pass

GI drugs most ___ ___ the gut & liver before becoming systemic.

Lower

First pass can ___ bioavailability of med.

Metabolized

Many drugs are ___ by liver.

Metabolized

Digestive process can ___ medications making less bioavailability.

P450

The ___ enzyme system metabilized many meds. (biotransfrom)

Urine

Major route of med excretion = ___.

Bile

Meds are excreted via ___ & then via defication baby

Excretion

Breast milk, saliva, & sweat are also vehicles for ___.

Bioavailability

Term for amt. of med that reaches blood.

Decreased

Food & stomach acid can ___ bioavailability

Decreased

First-pass biotransformation ___ bioavailability

Disintegration

Tablet ___ time can affect bioavailability

Pharmacutical

This is called a ___ effect on bioavailability

Biological

Food , enzymes, & stomach acid are ___ effects on Bioavailility

1/2 Life

Amount of time drug concentration is cut in half is called ___.

Steady-state

Drug intake = drug excretion is called ___.

Loading-Dose

Large intial dose followed by smaller ones= ___.

Maintanance

Dose given to induce steady -state is called ___ dose

Receptor

Place where med binds to cell is called ___.

Effect

Activity or efficacy reffers to drugs cellular ___.

Agonist

Drugs w/o receptor & receptor-mediated effect on cells are called ___.

Antagonist

Drugs binds to receptor w/ no effect = ___.

Complete

Antagonist ___ for receptors.

Efficacy

Drugs that have no cellular effect lack ___.

Tachyphylaxis

Short-term agonist effect that weakens = ___.

Desensitization

Other term for tachphylaxis =___.

Outside

Dose -response relationship referrs to amt of drug ___ cells

Cariomyopathy

Cadiotoxcitiy (med-related) can lead to ___.

Blood

Hematoppoietic toxicity leads to low ___ cell production.

PLTS

Blood cells effected by = RBC's/WBC, & ___.

Necrosis

Nephritis & tubular __- are seen in nephrotoxicity.

OTO

Ear & Ballancing disorders are seen in ___ toxicity.

Pulmonary

Lung fibrosis is seen in __ toxicity

Skin

Rashes are examples of med- induced ___ toxicity

Interaction

When the effect of a drug is changed by another drug, its an drug ___.

Interactions

Drug ___ change pharmcodynamics, Pharmacuetical or pharmcokinetic properties

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