Transplantation

15 terms by Rex126

Create a new folder

Advertisement Upgrade to remove ads

Autograph

tissue transplant from the same individual

Isograph

transplant from a genetically identical individual

Allograft

graft from a non genetically identical individual

Xenograft

graft from another species

rejection occurs in

Allograft and xenograft

Hyperacute rejection

rapid vascular occlusion within mins
intravascular clotting and thrombosis
not reversible
Class II MHC starts to be expressed, can be caused by blood group antigens
A TYPE 2 hypersensitivity, but looks like 3

Acute Graft Rejection

Days to years later
Acute cellular rejection (Necrosis, mild intestinal hemorrhage)
Mediated by CTL- lysis, DTH, Responsive to Cyclosporine
Antibodies may be inolved
complement activated
Necrotizing Vasculitis

Chronic Rejections

Months to years
Slow rise in creatine levels
intestinal fibrosis
Tubular atrophy in renal system
Ultimately results in Ischemia and loss of function

Graft vs host disease

occurs in bone marrow transplants, where the transplanted T-cells attack the recipients tissues

Cyclosporine

Prevents graft rejection
treats Graft Vs host
certain autoimmune disorders
dermatological disorders
sometimes used with corticosteroids
BLOCKS signaling for IL-2 Transription
Numerous Toxicities though

Tacrolimus

Similar MOA as Cyclosporin (Blocks IL-2)
binds to FK binding protein to block calcineurin
lots of toxicities
same indications as cyclosporine

Sirolimus

Binds to immunophilins and inhibits calcineurin
Does not block IL-2
Blocks T-cell response to Cytokines
Blocks B cell proliferation
Can be used with other immunosuppressives
Use similar to cyclosporin
Toxic like the others (profound myelosuppresion)

Mycophenolate Mofetil

Inhibits B and T cell proliferation
Inhibits de novo sythesis of purines
Used for refractory solid organ transplants
can treat lupus nephritis, RA and some derm. disorders

Gluccocorticoids

Reduces size of lymphoid content of lymph nodes and spleen
messes up cell cylce of activated lymphoid cells
Inhibits IL-1 (IL-3 - IL5, IL-8 and TNF-a)
Multiple indications
Multiple toxicities including bone mineral loss

Other treatments

antibodies specific for CD3, IL-2R, and CD40L

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions above and try again

Example:

Reload the page to try again!

Reload

Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

Star this term

You can study starred terms together

NEW! Voice Recording

Create Set