Neurotransmitters 2 (20)

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65 terms

Name a nicotinic receptor agonist.

nicotine

Name a muscarinic receptor agonist.

muscarine

Name a nicotinic receptor antagonist.

D-tubocurarine

Name a muscarinic receptor antagonist.

atropine

Name an alpha-1 receptor agonist.

phenylephrine

Name a non-selective irreversible alpha antagonist.

phenoxybenzamine

Name a non-selective Beta-agonist.

isoproterenol

Name a beta receptor antagonist.

propranolol

Name 2 types of glutamate receptors.

AMPA

NMDA

Name a AMPA agonist.

AMPA

Name a AMPA antagonist.

CNQX

Name a NMDA agonist.

NMDA

Name a NMDA antagonist.

AP5

Name 2 types of GABA receptors.

GABA(A)

GABA(B)

Name a receptor for glycine.

glycine receptor

Name a glycine receptor agonist.

glycine

Name a glycine receptor antagonist.

strychnine

Name the 2 main mechanisms by which glutamate is removed from the synaptic cleft.

diffusion into the presynaptic nerve terminal

uptake by glial cells (astrocytes)

Briefly describe uptake of glutamate by the glial cell.

Glutamate is taken into the astrocyte by a glutamate transporter. It is converted into glutamine by glutamine synthetase and then sent to the presynaptic nerve terminal by glutamine transporters. It undergoes reactions in the presynaptic nerve terminals to be converted back to glutamate.

What type of receptors are found on muscle cells?

nAChRs

What type of receptors are found on the organ walls for the PNS?

muscarinic receptors

ACh acts on _____ receptors in salivary, lacrimal, and other exocrine glands to _____ fluid and enzyme secretion.

M3

promote

ACh acts on _____ receptors in smooth muscle cells in gut walls, iris, ciliary body, bronchiolar muscle and bladder to _____ contraction.

M3 receptors

promote

ACh acts on _____ receptors in cells in stomach to _____ acid secretion.

M1 receptors

promote

ACh acts on _____ receptors in cardiac pacemaker to cause _____.

M2 receptor

slowing of heart

ACh acts on _____ and _____ receptors in cerebral cortex and hippocampus to produce excitatory responses.

M1

M3

ACh acts on _____ receptors in cerebral cortex and hippocampus to produce inhibitory responses.

M4

Most actions of ACh in brain are at _____ receptors. However, _____ receptors are found in terminals of the "brain reward circuit."

muscarinic

nicotinic

Fall in intracellular [cAMP] causes _____ of Ca2+ channels.

closure

Cholinergic neurons _____ cardiac pacemaker cells.

inhibit

Describe how postganglionic cholinergic neurons stimulate exocrine glands and smooth muscle contraction.

Describe how cholinergic neurons inhibit cardiac pacemaker cells through an indirect route.

Noradrenaline acts on _____ receptors in the heart to promote enhanced heart rate and contraction.

Beta-1 receptors

Catecholamines act on _____ receptors in bronchioles to promote relaxation of smooth muscle.

Beta 2

Catecholamines act on _____ receptors in blood vessels to promote vasoconstriction.

alpha 1

Describe how postganglionic sympathetic neurons excite cardiac muscle.

Postganglionic sympathetic neurons _____ cardiac muscle.

excite

Why does acetylcholine affect heart rate but not the strength of contraction?

Postganglionic fibers do not end on the ventricles--only on the pacemaker.

How does noradrenaline affect the heart in comparison to acetylcholine?

Both increase heart rate, but only noradrenaline increases contractility.

Sympathetic neurons release _____ onto sweat glands. There are _____ receptors in the secretory cells.

acetylcholine

M3

Dopamine has _____ and _____ receptors.

D1

D2

Dopaminergic neurons in the basal ganglia make projections that are involved in _____.

movement

Dopaminergic neurons in the _____ make projections on the hippocampus, nucleus accumbens and frontal lobe. They are responsible for _____.

ventral tegmentum

thought

D1 receptors are _____ receptors that facilitate rise in cAMP. This is associated with excitation.

metabotropic

D2 receptors mediate their actions by reducing _____. This is associated with inhibition.

cAMP

What type of drugs are administered for Parkinson's disease?

Dopamine agonists on D2 (and D1) receptors in the basal ganglia

What type of drugs are used to treat psychosis?

drugs acting as dopamine antagonists on D2 receptors in forebrain

Glycine only has _____ receptors.

ionotropic

GABA(A) receptors are _____ mediating _____ inhibition.

ionotropic receptors

synaptic

GABA(B) receptors are _____ receptors mediating _____ inhibition.

metabotropic, slow synaptic

Like glycine receptors, the GABA(A) receptors are _____ channels.

anion

Anti-anxiety drugs act on _____ receptor channels.

GABA(A)

_____ and _____ bind to sites on subunits of GABA receptor and enhance inhibitory response caused by GABA binding to receptor sites. This leads to inhibition of cells in the _____.

Benzodiazepines

barbiturates

amygdala

What are the 2 forms of ionotropic receptors for glutamate?

AMPA receptor

NMDA receptor

What ion blocks the binding site of NMDA receptors? How is it removed?

Mg2+

depolarization

Cholinergic, noradrenergic, and serotonergic neurons in the _____ and _____ make widespread projections to the thalamus and cortex to mediate arousal.

forebrain

brain stem

Noradrenergic and serotonergic neurons in the _____ make projections to the limbic lobe and cortex to mediate mood.

brain stem

What is the prominent ion that flows into the NMDA receptor upon activation.

Ca2+

Name 2 types of drugs used to treat clinical depression.

selective serotonin re-uptake inhibitors (SSRIs)

tricyclic antidepressants

Name a drug used in glaucoma treatment.

pilocarpine

What are Beta-1 blockers used for?

Rx of hypertension

What are Beta-2 blockers used for?

Rx of asthma

What are alpha-1 agonists used for?

Rx of nasal congestion

Name the disorder: unilateral lesion in pathway between hypothalamus and cervical ganglion.

Horner's syndrome

Name the disorder: paralysis of iris radial muscle, constricted pupil, droopy eyelids, dry face, no sweat.

Horner's syndrome

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