The distance between the site of protein production and the site of secretion can be considerably large relative to the neuron.
Briefly describe the particular intracellular transport problem that is faced by neuronal cells.
Fast anterograde, fast retrograde, slow (slower), and slow (faster)
List the four categories of fast and slow transport.
Rate (mm/day): 400-440; 200-270; 0.2-2.5; 0.4-5. Direction: anterograde; retrograde; anterograde; anterograde. Structures: organelles; endosomes & organelles; neurofilament and microtubule subunits; clathrin, actin, enzymes, & proteins. Cytoskeletal: All microtubules. Motor: Kinesin & KIFs; MAP-1C; none; none. ATP: Yes; yes; no; no.
Compare and contrast the fast anterograde, fast retrograde, slow (slower) and slow (faster) transport, respectively, using the following terms: rate, direction, structures transported, cytoskeletal elements involved, molecular motor(s), and ATP dependence.
Toxins (tetanus) and pathogens (herpes simplex, rabies, and polio) may be transported to the cell body (therefore CNS).
Explain why the indiscriminate nature of retrograde transport can be detrimental to a neuron.