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Presynapse NMJ
inhibit exocytosis Ach

Neomycin, Streptomycin, B-bungarotoxin, Botulinum Toxin

False transmitter
No longer used
Cholinergic synapse

Hemicholinium, triethylcholine

Cholinergic
H+-Ach symport inh

vesamicol

Antimetabolite

Sulphonamide (succinylcholine)

Achr agonist
Depolarising blocker
NMJ
pre- intubation, muscle relaxant
broken down by pseudocholinesterase

Suxemethonium

Comp antagonist
NMJ
Non depolarising blockers
lower e.p.p

D-tubocurarine

Organophosphate
Anticholinesterase- irriversible

Dyflos

Organophosphate poisoning reversal
Not cross BBB

Pralidoxine

catecholamine synthesis inhibitor
inhibits L-dopa

a-metirosine

catecholamine synthesis inhibitor
Parkinsons
inhibit L-DOPA to Dopamine

carbidopa/ benserazide

Parkinsons
With carbidopa/benserzide

L-Dopa

displacing agent
sympathetic receptor
nasal decongestant

pseudo-ephedrine

compete NA for re-uptake 1
converted to methyl-DA
transported into vesicles
antihypertensive
pre-eclampsia
activate a2 receptor
false transmitter

methyl-dopa

NA neurone blocking
not used in america
inhibits opening of Ca channels

Guanethidine

non selective beta agonist
cardiogenic shock
tachycardia, vasoconstriction

Dopamine, dobutamine

B2 agonist
Delay premature labour
Asthma
tachycardia, vasodilation, headache

Salbutamol

Relieve urinary retention

Darifenacin, tolterodine

B-antag
Arrythmias
angina
MI
congestive heart failure
glaucoma
acute panic attacks

propranolol

SSRI
antidepressant

Fluoxetine

Selective MAO-B inhibitor
antidepressent, parkinsons

Selegiline

Anticholinesterase
Short duration
Diagnosis MG

Edrophonium

Anticholinesterase
Medium Duration
Treatment of MG

Neostigmine

M3 antagonist
Reduce sweating

Glycopyronium

mixed alpha and beta antagonist
Heart Failure - hypertension

Carvilidlol

M3 antagonist
Used in eye tests-cycloplegia and mydriasis

Tropicamide

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