Advertisement Upgrade to remove ads

Ezetimibe

Cholesterol absorber inhibitor

Bile

Excess cholesterol stored

HMG-CoA Reductase

Rate limiting step in cholesterol synthesis
Inhibited by cholesterol
Inhibited glucagon
Activated by insulin

Xanthoma

Excess cholesterol stored in tendons

Fibrates

Increased HDL production
Enhance hepatic lipid metabolism

Familial Hypertriacylglycerolaemia

LPL deficiency
Increased TAG
Apo C2 deficiency

Familial Hypercholesterolaemia

LDL receptor deficiency
Xanthomas
Increased risk of CHD

GDA Omega 3 and 6

0.4g
2.0g

Aminotransferase

Alanine---> Pyruvate

glutamate dehydrogenase

a-ketoglutarate---> glutamate

Aspartate aminotransferase

oxaloacetate--> aspartate

3 phosphoglycerate--> ______---> cysteine+_______

serine
glycine

pyruvate--> _________

alanine

oxaloacetate--> _______---> asparagine

aspartate

a-ketoglutarate---> glutamate---> _______

glutamine

Muscle protein-> amino acid-> Glutamate-> Alanine

Alanine cycle

Alkaptonuria

Lack of homogentisic acid oxidase
Excrete homogentisic acid
Black urine
Phenylalanine--> tyrosine--> hydroxyphenylpyruvate--> homogentisic acid--> Fumarate

Phenylketonuria

PKU
1 in 10,000
Increase in phenylalanine
Mental retardation

RDA protein male and female

55g/day
44g/day

Reference proteins

Exact amount of protein needed for synthesis

Marasmus

Age: <18 months
Oedema: absent, severe wasting of body fat
Cause: sever malnutrition
Wrinkled skin, hair loss, thin

Kwashiorkor

Age: 1-5 years
Oedema: Present due to low plasma albumin
Odema hides wasting body
Cause: malnutrition
Features: Scaly skin, distended abdomen, hepatomegaly, sparse depigmented hair.

Vitamins

Cannot be synthesised in the body
Complex organic substance

Folate---> THF---> synthesis of purines, thymidine, glycine

Folic Acid (B9)

Ferritin

Main iron storage protein
Fe2+ and Haem

Transferrin

Transports iron between tissues.
Endocytosis
Receptor complex
Acidification of endosome released Fe3+ stored within ferritin

In iron deficiency ferritin translation ______ while transferrin receptor number ________

Decrease
Increase

Poly unsaturated fatty acid

Susceptible to free radical chain reactions

Superoxide Dismutase

Oxygen free radicals --> Oxygen and hydrogen peroxide

Glutathione Peroxidase

Selenium containing enzyme
Keeps SH part of amino acids reduced

Glutathione reductase

NADPH--> NADP

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions above and try again

Example:

Reload the page to try again!

Reload

Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

Star this term

You can study starred terms together

NEW! Voice Recording

Create Set