Muscle Disorders

13 terms by Humbug07

Create a new folder

Advertisement Upgrade to remove ads

Dystrophin

Stabilizes the sarcollema protects muscle fibre during contraction
Forms the dystrophin-glycoprotein complex

Duchennes Muscular Dystrophy

X linked recessive
pseudohypertrophy due to accumulation of muscle and fat

Beckers

Less dangerous form of muscle dystrophy

McArdles Disease

Myophosphorylase deficiency
Accumulation of glycogen
Impaired ability to produce lactic acid
muscle cramps

Channelopathies

Autosomal dominant
Dysfunction in muscle membrane
Periodic paralysis
Mytonic dystrophy

Periodic Paralysis

Leaking K+ back into cells
Initial inexciteability and thus paralysis
Myotonic dystrophy: Hyper-excitability and delayed relaxation of muscle

Congenital dystrophy

Inherited defect
Can cause mitochondrial, metabolic, membrane, muscular disorder
Progress slowly

DNA Analysis

Used to investigate disorders with major genetic component
Single gene disorders are easiest to identify
May require blood/ muscle samples
Used to detect DMD and Becker

Muscle Biopsy

Dystrophin labelling -DMD
Enzymes of glycolysis- Mc Ardles
Enzymes of oxidative metabolism

cytochrome C staining

Used to test respiratory chain abnormalities

Succinate dehydrogenase

Marker enzyme for mitochondria

Electromyography

Measure action potential of muscle
Useful to measure alterations in muscle action potential

Plasma CK analysis

Indicated muscle damage
Present in normal muscle after high amounts of eccentric contraction
Catalyses conversion of creatine and ADP to phosphocreatine and ADP

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions above and try again

Example:

Reload the page to try again!

Reload

Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

Star this term

You can study starred terms together

NEW! Voice Recording

Create Set