OneLiners - Antimicrobials

59 terms by JMihnovets 

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Inhibit DNA gyrase

MOA of quinolones

Block cell wall synthesis by inhibiting peptidoglycan cross-linkage

MOA of penicillin

Vancomycin

Drug used for MRSA

Blocks peptidoglycan synthesis

Vancomycin MOA

Point mutation

Type of resistance found with vancomycin

Rifampin

Meningitis prophylaxis in exposed patients

"Scotch tape technique and mebendazole"

Technique used to diagnose perianal itching, and the drug used to treat it

nephro and ototoxicity

Two toxicities of aminoglycosides

Erythromycin

DOC for Legionnaires' disease

Inhibit dihydropteroate synthase

MOA of sulfonamides

Methicillin, nafcillin, and dicloxacillin

Penicillins active against penicillinase secreting bacteria

Amoxicillin

Cheap wide spectrum antibiotic DOC for otitis media

Cephalosporins

Class of antibiotics that have 10% cross sensitivity with penicillins

Carbenicillin, piperacillin and ticarcillin

PCN active against pseudomonas

"Vancomycin, infusion at a slow rate and antihistamines"

Antibiotic causing red-man syndrome, and prevention

Tetracycline

Drug causes teeth discoloration

Decreases protein synthesis by inhibiting 30S ribosome

MOA of tetracycline

Chloramphenicol

Drug that causes gray baby syndrome and aplastic anemia

Clindamycin

Drug notorious for causing pseudomembranous colitis

Metronidazole

DOC for tx of pseudomembranous colitis

ORAL vancomycin

Treatment of resistant pseudomembranous colitis

Megaloblastic anemia

Anemia caused by trimethoprim

Cartilage damage

Reason fluoroquinolones are contraindicated in children and pregnancy

Metronidazole

DOC for giardia, bacterial vaginosis, pseudomembranous colitis, and trichomonas

Rifampin, Isoniazid, Pyrazinamide, and Ethambutol

Treatment for TB patients (think RIPE)

Disulfiram-like reaction

Metronidazole SE if given with alcohol

Red urine discoloration

Common side effect of Rifampin

Bind ergosterol in fungal cell membrane

MOA of nystatin

Administration of Vit. B6 (pyridoxine)

Neurotoxicity with isoniazid (INH) prevented by

Nephrotoxicity

Toxicity of amphotericin

Gynecomastia

SE seen only in men with administration of ketoconazole

Topical mupirocin (Bactroban)

Topical DOC in impetigo

Amantadine

DOC for influenza A

Ribavirin

DOC for RSV

Ganciclovir

DOC for CMV retinitis

Neutro, leuko and thrombocytopenia

SE for ganciclovir

Nevirapine, amprenavir

Anti-viral agents associated with Stephen Johnson syndrome

Protease inhibitors

HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism

Delavirdine, efavirenz, and ribavirin

Antivirals that are teratogens

Ganciclovir, zidovudine, saquinavir, and interferon

Antivirals associated with neutropenia

AZT (zidovudine)

HIV med used to reduce transmission during birth

Suramin

Drug used for African sleeping sickness

Nifurtimox

Drug used in Chagas disease

Cefuroxime (2nd) generation, Ceftazidime, Ceftriaxone

Cephalosporins able to cross the BBB

Cefixime (3rd) generation

Cephalosporins NOT able to cross the BBB

Ceftriaxone

Drug used for N. gonorrhea in females

Ceftriaxone or cefuroxime

Cephalosporin causes kernicterus in neonates

Peripheral neuritis and hepatitis

SE of INH

Streptomycin

Aminoglycoside that is least ototoxic

Primaquine

Drug used in exoerythrocytic cycle of malaria

Minocycline

Oral antibiotic of choice for moderate inflammatory acne

Dapsone, rifampin and clofazimine combination

Drug of choice for leprosy

Acyclovir; incorporated into viral DNA and chain termination

DOC for herpes and its MOA

Sulfonamides

Anti-microbials that cause hemolysis in G6PD-deficient patients

Inhibition of protein synthesis at the 50s subunit of ribosome

MOA of erythromycin

Sulfamethoxazole/Trimethoprim

Anti-biotic frequently used for chronic UTI prophylaxis

Aztreonam

Lactam that can be used in PCN allergic patients

Seizures

SE of imipenem

Didanosine

Anti-viral with a dose limiting toxicity of pancreatitis

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