Cell Division, cell cycle, meiosis, mitosis

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Created by:

ssommer20  on February 10, 2011

Subjects:

histology

Classes:

Life University Class of 2014

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Cell Division, cell cycle, meiosis, mitosis

Cell Division
-Growth in most multi-cellular organisms, increase in cell number
-Specialized cells have limited life spans, must be replaced.
-Proliferation of cells through cell division
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Terms

Definitions

Cell Division -Growth in most multi-cellular organisms, increase in cell number
-Specialized cells have limited life spans, must be replaced.
-Proliferation of cells through cell division
Mitosis the process by which a eukaryotic cell separates the chromosomes in its cell nucleus into two identical sets in two nuclei. It is generally followed immediately by cytokinesis.
Types of cells for mitosis Somatic or body cells
Karyokinesis process of nuclear division. aka mitosis
Cytokinesis Division of cytoplasm where a single eukaryotic cell is divided to form two daughter cells.
Interphase- Mitosis -Not resting phase
-Process of synthesizing DNA
-Structures during interphase
Nuclear envelope, nucleolus, dispersed chromatin material, cytoplasm, centrioles, -chromosomes during interphase are too uncoiled to be visible. Before prophase the chromosomes replicate
Prophase-Mitosis -Chromosomes become visible (short and thick).
-Nucleolus will diminish in size and disappear.
-Centrioles undergo reduplication then migrate to opposite poles of nucleus
-nuclear membrane begins to break down and disappear
Metaphase-Mitosis -Begins with the appearance of spindle fibers
-Chromosomes gather in center along equatorial plate
*Two types of fibers occur
Continuous and Chromosomal
Continuous vs Chromosomal Fiber Seen in Metaphase of Mitosis
-Continuous runs pole to pole
-Chromosomal runs from the pole to the centromere (1) of the chromosome
Centromere AKA ? Kinetochore
-Side note- centromeres usually contain DNA
Anaphase-Mitosis 1. doubling of the centromere (initial step)
2. separation of chromatids from each chromosome
3. Cleavage furrow starts to appear
Whats the initial step of anaphase in mitosis Centromere doubles
Telophase- Mitosis 1. Cleavage furrows continue
2. Nuclear membrane reforms
3.Chromosome again uncoils and becomes indistinct
4. Nucleolus reforms
5. At the end of telophase there are two daughter cells with identical chromosomes of the parents
Mitosis Phases in order Interphase, Prophase, Metaphase, Anaphase, Telephase
IPMAT
Cell Cycle Tissues culture---Cells undergo rapid growth and division.
-Constant doubling time is cell cycle
-Biochemical and morphological events repeat
Biochemical Events -Separation of the double helix of chromosomes and replication of each.
-Known as a semi conservative replication.
-Must keep constant number of chromosomes
-Parent chromosome goes to two new chromosomes consisting of the parent and a new synthesized chromosome.
S Phase 1.Period of active DNA synthesis
2. Lasts 6-8 hours
3. 30-40% of cycle
G1 Phase 1. Period of active RNA and protein synthesis
2. Both the nucleus and cytoplasm of daughter cells enlarge
3. 30-40% of cycle
G2 Phase 1. Period in which there is no DNA synthesis
2. Both other preparations for division take place
3. 10-20% cycle
M Phase 1. Consists of those structural events which occur during mitosis.*
2. P/M/A/T g1 S and G2 all occur during INTERPHASE (NOT RESTING AT ALL)
M Phase 2 divisions
1. Karyoknesis
2.Cytokinesis
Meiosis- Def -Development of male and female reproductive cells.
-Form of cell division
Meiosis- What happens in general Two successive nuclear divisions with only one replication of the chromosomes, resulting in four daughter cells with 1/2 the chromosome numbers of the mother/father cell (haploid)
Meiosis first mitotic division Reductional Division- Chromosome Number is reduced
Meiosis Second division Equational division.
Importance of meiosis -Constant chromosome number from generation to generation. Meiosis is characterized bu a very long prophase I which can be divided into 5 stages.
Lepotene 1st of prophase I of meiosis
-chromosomes are thin and threadlike
-have beadlike structures- chromomeres function unknown
Zygotene 2nd Part of prophase I meiosis
-homologous chromosomes begin to pair (synapse) CROSSING OVER OCCURS PROPHASE 1
-paring continues throughout this phase**
Pachytene 3rd part of prophase I meiosis
-Shortening of the chromosomes- 1/4 the length
-Theory- Precursors (DNA) are added
-Pairing of chromosomes is completed
Diplotene4th and last part of prophase I meiosis
-intimately paired chromosomes begin to repel each other and sererate.
-During this stage, chromosomes do not completely seperate, they remain joined at a certain points where two of the 4 chromatids form an x crossing over one another
-X points referred to as chiasmata (crossing over) exchange material**
-nucleolus breaks down
Diakinesis Chromosomes at max condensation
Nuclear membrane breaks down
Metaphase I Meiosis 1. Tetrads- chromosomes that have duplicated, therefore 4 tetrads (chromatids) line up along equator
2. Nuclear envelop disappears
Anaphase I Meiosis Homologues seperate
Telophase I Meiosis in some cells cytokinesis does not occur, so you end up with two nuclei in one cell-
--does not happen in mammals
Interphase II Interkinesis (no dna replication)
Prophase II Spindles appear as nuclear membrane breaks down
Metaphase Chromatids pairs of chromosome line up on the equator
Anaphase II Centromeres duplicate and divide
Chromatids of chromosomes separate and move to opposite poles
Telophase II Spindles disappear
nuclear membrane reappears
cell membrane furrow forms
four cells result in haploid*
Mitosis VS Miosis Mitosis- 2C-4C-2C Meosis 2C-4C-2C-1C

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