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nonspecific

alkylating agents are cell-cycle ______________

orally, food. (when you are cycling you need food easily digested in mouth)

cyclophosphamide can be administered ___________. Make sure to give with _________

Ifosfamide, mesna, extensive hydration

A nitrogen mustard Alkylating agent called _________ can cause urotoxicity resulting in hemorrhagic cystitis. This can be minimized by concurrent therapy with ____ and _______ ______

mechlorethamine, exposure (avoidance)

A nitrogen mustard Alkylating agent called _________ is black boxed for extravasation and and ________ avoidance!!!

estromustine

___________ is similar structurally to estrogen-- and carries similar risks. Thrombosis, edema, gynecomatia. Avoid giving with calcium and take on empty stomach.

Nitrosoureas

The great thing about the alkylating agent class ________ is that they can cross the **blood brain barrier**

carmustine, lomustine

The Nitrosourease drugs (alkylating) ______ and ________ are both dose limiting due to *DELAYED* myelo-suppression (4-6 weeks post tx) BBB (2/3)

streptozocin, kidney, peripheral neuropathy (throat feels like pins and needles)

the Nitrosourease drug (alkylating agent) ________ has a glucose moiety, and is selectively taken into islet cells in the pancreas. Risk is hypoglycemia and ______ damage. and ______ _______ . BBB (1/3)

Temodar

This alkylating agent ____________ the uncrushed pill must be taken on an empty stomach.

hepatotoxicity

another alkylating agent, Dacarbazine is blackboxed for ____________ (in addition to carcinogenicity and myelosuppression)

Matulane (mat went to tulane and got depressed)

an alkylating agent (other), ________ is an inhibitor of MAO- so it is contraindicated with the use of MAO-I and SSRIs and high tyramine foods

hexalen (A hex will drive someone crazy)

____________, is associated with neurotixicity

rapidly proliferating

____________ _____________ cells are most sensitive to all chemotherapy agents (cycle specific/nonspecific

with food

Give cytoxan ____ _____

ifosfamide, mesna

hemorrhagic cycstitis caused by _________can be reduced by giving _______ and extensive hydration.

hematuria

before administering Ifosfamide make sure to do a urinalysis, and if micro _______ are present, hold off on drug

MOA, toxicities,

when giving chemo: you want to be able to do 3 things 1) multiple drugs with different _____ 2) no cumulative __________ 3) no drug interactions

pulmonary toxicity

risk with carmustine is dose related ___________

Busulfan

_________ causes severe bone marrow hypoplasia

hepatotoxicity

Dacarbazine is blackboxed for

neurotoxicity

Hexalen can cause ________

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