Hypersensitivity (IV)

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Type IV is known as

Delayed (Cellular) hypersensitivity (DTH)

DTH can be transferred from a sensitized person to a non-sensitized person by:

sensitized T-lymphocytes or
by a factor from extracts of T-lymphocytes called transfer (TF) which turns on a precommited, Ag-sensitive, T-lymphocyte.

Transfer factor

Substance occurring in T-lymphocytes w/ capacity to transfer delayed hypersensitivity (Type IV) to a normal (non-reactive) individual.

(T/F) Type IV has the same mechanism as CMI

True

Cutaneous reactions to poison ivy and oil poison are example of which type of hypersensitivity?

IV

(T/F) delayed hypersensitivty can be transferred by serum.

False

only by T-cells

Mantoux reaction

term refers to the skin test for tuberculosis. the skin reaction which develops in individuals who have been immunized to tuberculin is a DTH response.

» All members of the genus would elicit the same response.

Locally, DTH is not a big problem. Systemically it is.

Which of the following does not cause DTH?

a. peanut
b. soaps
c. metals
d. poison ivy
e. rubber

a. peanut ✓ → Type I
b. soaps
c. metals
d. poison ivy
e. rubber

Migration Inhibition Factor (MIF)

Stops movement of MΦ.

chemokine

a small protein that directs the migration of phagocytes toward an infected cell and signals them to increase productionf of microbe-killing compounds; part of the inflammatory response.

(T/F) TH1 release INF<SUB>γ</SUB> (cytokine) which activates MΦ

True

TH1 cells also release IL3 and GM-CSF → monocyte production in Bone marrow

Cytotoxines

substance with a specific toxic effect on certain cells.

TH1 cells release INF-α and TNF-β which lead to local tissue destruction.

What are some common conditions associated with DTH?

1. organ <i>allograph</i> rejection
2. Parasite clearance
3. some autoimmune phenomena

Which of the following statements are true?

a. In America, M. tuberculosis is pulmonary
b. M. Brovis can be acquired by consuming contaminated milk and vaccine mostly protects agaisnt this.
c. Vaccination is not recommended in America

All true

Which is true about hypersensitvities:

a. mechanism are NOT abnormal
b. problem is with <b>regulation</b>

both statements are true

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