Anemias and leukemias

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ALL Acute lymphocytic leukemia

Rapid onset
Affects children
Of acute leukemias, the most responsive to tx

AML Acute myelogenous Leukemia

Rapid onset
Mostly adults
Worst response to tx of all

CLL Chronic lymphocytic leukemia

Slow progression
>60 ys
M>F
Abnormally small lymphocytes
Lymphoid tissue in blood
Bone marrow

CML Chronic myelogenous leukemia

Slow progression
Middle-aged adults. Rare in children
Philadelphia chromosome
Caused by carcinogenic chemicals and radiation
+Granulocytic precursors (myeloblasts and promyelocytes)

Autoimmune Hemolytic anemia

IgG antibodies combine w/ RBC surface antigens
Antibody coated RBC are sequestered in the spleen (where hemolysis occurs)

Erythroblasosis fetalis

Mother's antibodies attack fetal RBCs when different Rh factor

Sickle cell anemia

African americans
Inherited autosomal recessive
Abnormal type of hemoglobin Hb-S
Valine substituted for glutamic acid in the sixth position

Pernicious anemia

Autoimmune disorder
Lack of intrinsic factor
B12, necessary for RBC formation, is not absorbed in the GI tract because of the lack of IF
Macrocytic anemia
Stomatitis and glositis

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